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Peptide-Based Anti-PCSK9 Vaccines - An Approach for Long-Term LDLc Management

Galabova, Gergana ; Brunner, Sylvia ; Winsauer, Gabriele ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 12 ( 2014-12-4), p. e114469-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 12 ( 2014-12-4), p. e114469-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0114469

DOI: 10.1371/journal.pone.0114469.g001

DOI: 10.1371/journal.pone.0114469.g002

DOI: 10.1371/journal.pone.0114469.g003

DOI: 10.1371/journal.pone.0114469.g004

DOI: 10.1371/journal.pone.0114469.g005

DOI: 10.1371/journal.pone.0114469.g006

DOI: 10.1371/journal.pone.0114469.g007

DOI: 10.1371/journal.pone.0114469.s001

DOI: 10.1371/journal.pone.0114469.s002

DOI: 10.1371/journal.pone.0114469.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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Thrombin cleavage of osteopontin initiates osteopontin’s tumor‐promoting activity

Peraramelli, Sameera ; Zhou, Qi ; Zhou, Qin ; [et al.]

Elsevier BV ; 2022

In: Journal of Thrombosis and Haemostasis Vol. 20, No. 5 ( 2022-05), p. 1256-1270

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In: Journal of Thrombosis and Haemostasis, Elsevier BV, Vol. 20, No. 5 ( 2022-05), p. 1256-1270

Type of Medium: Online Resource

ISSN: 1538-7836

URL: Article

DOI: 10.1111/jth.15663

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2099291-9

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Peptide-based vaccination against OPN integrin binding sites does not improve cardio-metabolic disease in mice

Grün, Nicole G. ; Strohmeier, Karin ; Moreno-Viedma, Veronica ; [et al.]

Elsevier BV ; 2016

In: Immunology Letters Vol. 179 ( 2016-11), p. 85-94

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In: Immunology Letters, Elsevier BV, Vol. 179 ( 2016-11), p. 85-94

Type of Medium: Online Resource

ISSN: 0165-2478

URL: Article

DOI: 10.1016/j.imlet.2016.09.006

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2013171-9

SSG: 12

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Osteopontin affects macrophage polarization promoting endocytic but not inflammatory properties

Schuch, Karina ; Wanko, Bettina ; Ambroz, Katharina ; [et al.]

Wiley ; 2016

In: Obesity Vol. 24, No. 7 ( 2016-07), p. 1489-1498

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In: Obesity, Wiley, Vol. 24, No. 7 ( 2016-07), p. 1489-1498

Abstract: Macrophages are the main drivers of obesity‐induced adipose tissue (AT) inflammation that causes insulin resistance. Macrophages polarize toward different inflammatory (M1) or protective (M2) phenotypes. Osteopontin (OPN) is an inflammatory cytokine highly expressed in AT in obesity and known to be involved in chronic inflammatory processes. It was hypothesized that OPN polarizes macrophages into a proinflammatory phenotype. Methods AT macrophages (ATMs) of OPN‐deficient ( Spp1 −/− ) and wild‐type C57BL/6 (WT) mice with obesity and bone marrow‐derived macrophages (BMDMs) of Spp1 −/− and WT mice as well as human monocyte‐derived macrophages (MDMs) polarized in the presence of OPN were investigated. Results While ATM infiltration was lower in Spp1 −/− upon high‐fat diet, Spp1 −/− ATMs expressed more M1 and less M2 markers but less tumor necrosis factor‐α compared with WT. There was no effect of OPN deficiency on BMDM polarization. In human MDMs, the presence of OPN during polarization ambiguously altered M1/M2‐related marker expression and diminished LPS‐induced inflammatory cytokine production. Strikingly, phagocytic activity was elevated by the presence of OPN during polarization in both human MDMs and murine BMDMs. Conclusions In contradiction to our hypothesis, data indicated that OPN does not induce inflammatory macrophages but was a signal to induce phagocytosis, which may be required due to increased adipocyte death in obesity.

Type of Medium: Online Resource

ISSN: 1930-7381 , 1930-739X

URL: Issue

URL: Article

DOI: 10.1002/oby.v24.7

DOI: 10.1002/oby.21510

Language: English

Publisher: Wiley

Publication Date: 2016

detail.hit.zdb_id: 2027211-X

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Osteopontin is a key player for local adipose tissue macrophage proliferation in obesity

Tardelli, Matteo ; Zeyda, Karina ; Moreno-Viedma, Veronica ; [et al.]

Elsevier BV ; 2016

In: Molecular Metabolism Vol. 5, No. 11 ( 2016-11), p. 1131-1137

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In: Molecular Metabolism, Elsevier BV, Vol. 5, No. 11 ( 2016-11), p. 1131-1137

Type of Medium: Online Resource

ISSN: 2212-8778

URL: Article

DOI: 10.1016/j.molmet.2016.09.003

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2708735-9

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Antibody-mediated targeting of cleavage-specific OPN-T cell interactions

Wanko, Bettina ; Tardelli, Matteo ; Jürets, Alexander ; [et al.]

Public Library of Science (PLoS) ; 2019

In: PLOS ONE Vol. 14, No. 4 ( 2019-4-5), p. e0214938-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 14, No. 4 ( 2019-4-5), p. e0214938-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0214938

DOI: 10.1371/journal.pone.0214938.g001

DOI: 10.1371/journal.pone.0214938.g002

DOI: 10.1371/journal.pone.0214938.g003

DOI: 10.1371/journal.pone.0214938.g004

DOI: 10.1371/journal.pone.0214938.g005

DOI: 10.1371/journal.pone.0214938.g006

DOI: 10.1371/journal.pone.0214938.g007

DOI: 10.1371/journal.pone.0214938.s001

DOI: 10.1371/journal.pone.0214938.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2019

detail.hit.zdb_id: 2267670-3

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TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding

Wyseure, Tine ; Yang, Tingyi ; Zhou, Jenny Y. ; [et al.]

American Society for Clinical Investigation ; 2019

In: JCI Insight Vol. 4, No. 19 ( 2019-10-3)

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In: JCI Insight, American Society for Clinical Investigation, Vol. 4, No. 19 ( 2019-10-3)

Type of Medium: Online Resource

ISSN: 2379-3708

URL: Article

DOI: 10.1172/jci.insight.128379

DOI: 10.1172/jci.insight.128379DS1

Language: English

Publisher: American Society for Clinical Investigation

Publication Date: 2019

detail.hit.zdb_id: 2874757-4

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