In:
Neurodegenerative Diseases, S. Karger AG, Vol. 10, No. 1-4 ( 2012), p. 135-137
Abstract:
〈 i 〉 Background: 〈 /i 〉 Physical activity and cardiorespiratory fitness relate to better cognitive performance. Little is known about the effects of fitness on structural brain abnormalities in the elderly. 〈 i 〉 Objective: 〈 /i 〉 Assess the association between maximal oxygen consumption (VO 〈 sub 〉 2 〈 /sub 〉 max), white matter lesion (WML) volume and brain parenchymal fraction (BPF) in a large cohort of community-dwelling elderly individuals. 〈 i 〉 Methods: 〈 /i 〉 The study population consisted of 715 participants of the Austrian Stroke Prevention Study who underwent brain MRI with semi-automated measurement of WML volume (cm 〈 sup 〉 3 〈 /sup 〉 ) and automated assessment of BPF (%) by the use of SIENAX. A maximal exercise stress test was done on a bicycle ergometer. VO 〈 sub 〉 2 〈 /sub 〉 max was calculated based on maximum and resting heart rate. 〈 i 〉 Results: 〈 /i 〉 After adjustment for possible confounders, VO 〈 sub 〉 2 〈 /sub 〉 max was independently associated with WML volume (β = –0.10; p = 0.02); no significant relationship existed with silent cerebral infarcts and BPF. Associations between VO 〈 sub 〉 2 〈 /sub 〉 max and WML load were only significant in men, but not in women. 〈 i 〉 Conclusion: 〈 /i 〉 Our findings may have important preventive implications because WMLs are known to be a major determinant of cognitive decline and disability in old age.
Type of Medium:
Online Resource
ISSN:
1660-2854
,
1660-2862
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
2126858-7
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