In:
The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 223, No. 3 ( 2021-02-13), p. 522-526
Abstract:
Our current knowledge of the clinical burden, biology, and transmission of Plasmodium malariae is extremely scarce. To start addressing some of those questions, we experimentally infected Anopheles gambiae mosquitoes with fresh P. malariae isolates obtained from asymptomatic individuals in Lambaréné, Gabon. The proportion of mosquitoes infected via direct membrane feeding assay with either P. malariae monoinfections (16% [19 of 121]) or coinfections (28% [31 of 112] ) was higher after serum replacement than in parallel groups without serum replacement (4% [4 of 102] and 4% [2 of 45] , respectively; P & lt; .01). Our results show that isolates from asymptomatic carriers can be used for experimental studies of P. malariae transmission.
Type of Medium:
Online Resource
ISSN:
0022-1899
,
1537-6613
DOI:
10.1093/infdis/jiaa382
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2021
detail.hit.zdb_id:
1473843-0
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