In:
Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 37, No. 01 ( 1977), p. 062-072
Abstract:
The amantadine derivative 1.3-dimethyl-5-aminoadamantane, D 145, induces in high concentrations of 2–10 mM the release reaction. Adenine nucleotides and 5-hydroxytryptamine (5-HT) are liberated to the same extent and in the same ratio as found after thrombin-induced release. The time course of release is very slow; maximal release is reached in 15–20 min. The process is temperature-dependent and dependent on energy derived from glycolysis and oxidative phosphorylation. Extracellular Ca++ does not promote the release process. D 145, in accordance with the mother-substance amantadine, inhibits 5-HT uptake non-competitively, KI = 0.15 mM. In concentrations of 0.1–1 mM D 145 triggers only the liberation of 5-HT, adenine nucleotides are not liberated. The ADP induced platelet aggregation is completely inhibited after preincubation with a 1 mM solution of D 145.
Type of Medium:
Online Resource
ISSN:
0340-6245
,
2567-689X
DOI:
10.1055/s-0038-1649202
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
1977
Bookmarklink