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Bundling of axons through a capillary alginate gel enhances the detection of axonal action potentials using microelectrode arrays

George, Dale S. ; Anderson, Wesley A. ; Sommerhage, Frank ; [et al.]

Hindawi Limited ; 2019

In: Journal of Tissue Engineering and Regenerative Medicine Vol. 13, No. 3 ( 2019-03), p. 385-395

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In: Journal of Tissue Engineering and Regenerative Medicine, Hindawi Limited, Vol. 13, No. 3 ( 2019-03), p. 385-395

Type of Medium: Online Resource

ISSN: 1932-6254 , 1932-7005

URL: Issue

URL: Article

DOI: 10.1002/term.v13.3

DOI: 10.1002/term.2793

Language: English

Publisher: Hindawi Limited

Publication Date: 2019

detail.hit.zdb_id: 2316155-3

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Exposure to nanoceria impacts larval survival, life history traits and fecundity of Aedes aegypti

Doshi, Mona ; Bosak, Alexander ; Neal, Craig J. ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Neglected Tropical Diseases Vol. 14, No. 9 ( 2020-9-25), p. e0008654-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 14, No. 9 ( 2020-9-25), p. e0008654-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0008654

DOI: 10.1371/journal.pntd.0008654.g001

DOI: 10.1371/journal.pntd.0008654.g002

DOI: 10.1371/journal.pntd.0008654.g003

DOI: 10.1371/journal.pntd.0008654.g004

DOI: 10.1371/journal.pntd.0008654.g005

DOI: 10.1371/journal.pntd.0008654.g006

DOI: 10.1371/journal.pntd.0008654.g007

DOI: 10.1371/journal.pntd.0008654.g008

DOI: 10.1371/journal.pntd.0008654.g009

DOI: 10.1371/journal.pntd.0008654.g010

DOI: 10.1371/journal.pntd.0008654.g011

DOI: 10.1371/journal.pntd.0008654.t001

DOI: 10.1371/journal.pntd.0008654.t002

DOI: 10.1371/journal.pntd.0008654.s001

DOI: 10.1371/journal.pntd.0008654.s002

DOI: 10.1371/journal.pntd.0008654.s003

DOI: 10.1371/journal.pntd.0008654.s004

DOI: 10.1371/journal.pntd.0008654.s005

DOI: 10.1371/journal.pntd.0008654.s006

DOI: 10.1371/journal.pntd.0008654.s007

DOI: 10.1371/journal.pntd.0008654.s008

DOI: 10.1371/journal.pntd.0008654.s009

DOI: 10.1371/journal.pntd.0008654.s010

DOI: 10.1371/journal.pntd.0008654.s011

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2429704-5

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Use of a capillary alginate gel (Capgel™) to study the three-dimensional development of sensory nerves reveals the formation of a rudimentary perineurium

Anderson, Wesley A. ; Willenberg, Alicia R. ; Bosak, Alexander J. ; [et al.]

Elsevier BV ; 2018

In: Journal of Neuroscience Methods Vol. 305 ( 2018-07), p. 46-53

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In: Journal of Neuroscience Methods, Elsevier BV, Vol. 305 ( 2018-07), p. 46-53

Type of Medium: Online Resource

ISSN: 0165-0270

URL: Article

DOI: 10.1016/j.jneumeth.2018.05.003

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1500499-5

SSG: 12

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Capillary alginate gel (Capgel™) for the treatment of full-thickness dermal wounds in a hypoxic mouse model

Bosak, Alexander ; Kwan, Michael W. C. ; Willenberg, Alicia ; [et al.]

Informa UK Limited ; 2019

In: International Journal of Polymeric Materials and Polymeric Biomaterials Vol. 68, No. 18 ( 2019-12-12), p. 1108-1117

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In: International Journal of Polymeric Materials and Polymeric Biomaterials, Informa UK Limited, Vol. 68, No. 18 ( 2019-12-12), p. 1108-1117

Type of Medium: Online Resource

ISSN: 0091-4037 , 1563-535X

URL: Article

DOI: 10.1080/00914037.2018.1534112

Language: English

Publisher: Informa UK Limited

Publication Date: 2019

detail.hit.zdb_id: 2711982-8

detail.hit.zdb_id: 2045637-2

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An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats

Rocca, Domenico G. Della ; Willenberg, Bradley J. ; Qi, Yanfei ; [et al.]

Elsevier BV ; 2016

In: International Journal of Cardiology Vol. 220 ( 2016-10), p. 149-154

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In: International Journal of Cardiology, Elsevier BV, Vol. 220 ( 2016-10), p. 149-154

Type of Medium: Online Resource

ISSN: 0167-5273

URL: Article

DOI: 10.1016/j.ijcard.2016.06.158

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 1500478-8

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AN INJECTABLE ACELLULAR CAPILLARY HYDROGEL IMPROVES LEFT VENTRICULAR FUNCTION AFTER MYOCARDIAL INFARCTION

Rocca, Domenico G. Della ; Willenberg, Bradley J. ; Franklin, Leonardo F. ; [et al.]

Elsevier BV ; 2012

In: Journal of the American College of Cardiology Vol. 59, No. 13 ( 2012-03), p. E856-

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In: Journal of the American College of Cardiology, Elsevier BV, Vol. 59, No. 13 ( 2012-03), p. E856-

Type of Medium: Online Resource

ISSN: 0735-1097

URL: Article

DOI: 10.1016/S0735-1097(12)60857-2

RVK:

XA 17760

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1468327-1

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Detailed analysis of polymer response to delivery balloon expansion of drug-eluting stents versus bare metal stents

Denardo, Scott J. ; Carpinone, Paul L. ; Vock, David M. ; [et al.]

Europa Digital & Publishing ; 2013

In: EuroIntervention Vol. 9, No. 3 ( 2013-7), p. 389-397

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In: EuroIntervention, Europa Digital & Publishing, Vol. 9, No. 3 ( 2013-7), p. 389-397

Type of Medium: Online Resource

ISSN: 1774-024X

URL: Article

DOI: 10.4244/EIJV9I3A62

Language: Unknown

Publisher: Europa Digital & Publishing

Publication Date: 2013

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A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction

Della Rocca, Domenico G. ; Willenberg, Bradley J. ; Ferreira, Leonardo F. ; [et al.]

Elsevier BV ; 2012

In: Medical Hypotheses Vol. 79, No. 5 ( 2012-11), p. 673-677

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In: Medical Hypotheses, Elsevier BV, Vol. 79, No. 5 ( 2012-11), p. 673-677

Type of Medium: Online Resource

ISSN: 0306-9877

URL: Article

DOI: 10.1016/j.mehy.2012.08.006

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 2002471-X

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Engineered Human Tissue as A New Platform for Mosquito Bite-Site Biology Investigations

Seavey, Corey E. ; Doshi, Mona ; Panarello, Andrew P. ; [et al.]

MDPI AG ; 2023

In: Insects Vol. 14, No. 6 ( 2023-06-02), p. 514-

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In: Insects, MDPI AG, Vol. 14, No. 6 ( 2023-06-02), p. 514-

Abstract: Vector-borne diseases transmitted through the bites of hematophagous arthropods, such as mosquitoes, continue to be a significant threat to human health globally. Transmission of disease by biting arthropod vectors includes interactions between (1) saliva expectorated by a vector during blood meal acquisition from a human host, (2) the transmitted vector-borne pathogens, and (3) host cells present at the skin bite site. Currently, the investigation of bite-site biology is challenged by the lack of model 3D human skin tissues for in vitro analyses. To help fill this gap, we have used a tissue engineering approach to develop new stylized human dermal microvascular bed tissue approximates—complete with warm blood—built with 3D capillary alginate gel (Capgel) biomaterial scaffolds. These engineered tissues, termed a Biologic Interfacial Tissue-Engineered System (BITES), were cellularized with either human dermal fibroblasts (HDFs) or human umbilical vein endothelial cells (HUVECs). Both cell types formed tubular microvessel-like tissue structures of oriented cells (82% and 54% for HDFs and HUVECs, respectively) lining the unique Capgel parallel capillary microstructures. Female Aedes (Ae.) aegypti mosquitoes, a prototypic hematophagous biting vector arthropod, swarmed, bit, and probed blood-loaded HDF BITES microvessel bed tissues that were warmed (34–37 °C), acquiring blood meals in 151 ± 46 s on average, with some ingesting ≳4 µL or more of blood. Further, these tissue-engineered constructs could be cultured for at least three (3) days following blood meal acquisitions. Altogether, these studies serve as a powerful proof-of-concept demonstration of the innovative BITES platform and indicate its potential for the future investigation of arthropod bite-site cellular and molecular biology.

Type of Medium: Online Resource

ISSN: 2075-4450

URL: Article

DOI: 10.3390/insects14060514

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 2662247-6

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Fabrication of Coated Polycaprolactone Scaffolds and Their Effects on Murine Embryonic Stem Cells

Tollon, Michael H. ; Hamazaki, Takashi ; Willenberg, Bradley J. ; [et al.]

Springer Science and Business Media LLC ; 2005

In: MRS Proceedings Vol. 873 ( 2005)

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In: MRS Proceedings, Springer Science and Business Media LLC, Vol. 873 ( 2005)

Abstract: In the past decade, tissue engineering has become a great interest in materials science research. Embryonic stem (ES) cell transplantation has become one of the most researched therapies for restoring tissue and organ function. Many studies have investigated the use of porous biodegradable scaffolds to promote cell adhesion, growth, proliferation, differentiation, and to help steer the course of tissue development. Research has shown that extracellular matrices and the basement membranes affect various cell types and cellular behaviors. However, the effects of these materials on ES cell behavior are currently understudied and poorly understood. In this study, the synthetic biodegradable polymer polycaprolactone (PCL) was chosen to create an interconnected, fibrous foam structure. A phase separated scaffold method was developed and the product made was coated with various extracellular materials. When the phase separated PCL scaffolds were coated with Matrigel and gelatin solutions, murine ES (mES) cells attached, spread, and differentiated within the scaffolds. There was little growth on the uncoated material. Coating effects on mES cells were analyzed using flow cytometry, reverse-transcriptase polymerase chain reaction and scanning electron microscopy. It was found that coating the scaffold with different extracellular matrices affects mES cell morphology and differentiation. Matrigel coating causes expression of neural proteins and gelatin produces a hepatocyte-like cell.

Type of Medium: Online Resource

ISSN: 0272-9172 , 1946-4274

URL: Article

DOI: 10.1557/PROC-873-K9.14

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2005

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