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Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants

Bournazos, Adam M. ; Riley, Lisa G. ; Bommireddipalli, Shobhana ; [et al.]

Elsevier BV ; 2022

In: Genetics in Medicine Vol. 24, No. 1 ( 2022-01), p. 130-145

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In: Genetics in Medicine, Elsevier BV, Vol. 24, No. 1 ( 2022-01), p. 130-145

Type of Medium: Online Resource

ISSN: 1098-3600

URL: Article

DOI: 10.1016/j.gim.2021.09.001

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2063504-7

SSG: 12

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Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

Thaweethai, Tanayott ; Jolley, Sarah E. ; Karlson, Elizabeth W. ; [et al.]

American Medical Association (AMA) ; 2023

In: JAMA Vol. 329, No. 22 ( 2023-06-13), p. 1934-

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In: JAMA, American Medical Association (AMA), Vol. 329, No. 22 ( 2023-06-13), p. 1934-

Abstract: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID . Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. Objective To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections. Design, Setting, and Participants Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling. Exposure SARS-CoV-2 infection. Main Outcomes and Measures PASC and 44 participant-reported symptoms (with severity thresholds). Results A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%] ) were PASC positive at 6 months. Conclusions and Relevance A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.

Type of Medium: Online Resource

ISSN: 0098-7484

URL: Article

DOI: 10.1001/jama.2023.8823

RVK:

XA 10000

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2023

detail.hit.zdb_id: 2958-0

detail.hit.zdb_id: 2018410-4

SSG: 5,21

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Early years postgraduate surgical training programmes in the UK are failing to meet national quality standards: An analysis from the ASiT/BOTA Lost Tribe prospective cohort study of 2,569 surgical trainees

Glasbey, James C. ; Harries, Rhiannon L. ; Beamish, Andrew J. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2018

In: International Journal of Surgery Vol. 52 ( 2018-04), p. 376-382

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In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 52 ( 2018-04), p. 376-382

Type of Medium: Online Resource

ISSN: 1743-9191

URL: Article

DOI: 10.1016/j.ijsu.2017.09.074

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2018

detail.hit.zdb_id: 2201966-2

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The Use of Hierarchical Generalized Linear Model for Item Dimensionality Assessment

Beretvas, S. Natasha ; Williams, Natasha J.

Wiley ; 2004

In: Journal of Educational Measurement Vol. 41, No. 4 ( 2004-12), p. 379-395

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In: Journal of Educational Measurement, Wiley, Vol. 41, No. 4 ( 2004-12), p. 379-395

Type of Medium: Online Resource

ISSN: 0022-0655 , 1745-3984

URL: Issue

URL: Article

DOI: 10.1111/jedm.2004.41.issue-4

DOI: 10.1111/j.1745-3984.2004.tb01172.x

Language: English

Publisher: Wiley

Publication Date: 2004

detail.hit.zdb_id: 2066579-9

detail.hit.zdb_id: 218333-X

SSG: 5,2

SSG: 5,3

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It's Not Effect Sizes So Much as Comments About Their Magnitude That Mislead Readers

Robinson, Daniel H. ; Whittaker, Tiffany A. ; Williams, Natasha J. ; [et al.]

Informa UK Limited ; 2003

In: The Journal of Experimental Education Vol. 72, No. 1 ( 2003-01), p. 51-64

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In: The Journal of Experimental Education, Informa UK Limited, Vol. 72, No. 1 ( 2003-01), p. 51-64

Type of Medium: Online Resource

ISSN: 0022-0973 , 1940-0683

URL: Article

DOI: 10.1080/00220970309600879

Language: English

Publisher: Informa UK Limited

Publication Date: 2003

detail.hit.zdb_id: 218166-6

detail.hit.zdb_id: 2066584-2

SSG: 5,3

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DIF Identification Using HGLM for Polytomous Items

Williams, Natasha J. ; Beretvas, S. Natasha

SAGE Publications ; 2006

In: Applied Psychological Measurement Vol. 30, No. 1 ( 2006-01), p. 22-42

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In: Applied Psychological Measurement, SAGE Publications, Vol. 30, No. 1 ( 2006-01), p. 22-42

Abstract: The relationship between the hierarchical generalized linear model (HGLM) and item response theory (IRT) models has been demonstrated for dichotomous items. The current study demonstrated the use of the HGLM for polytomous items (termed PHGLM) for identification of differential item functioning (DIF). First, the algebraic equivalence between parameterizations of a constrained form of Muraki's rating scale model and PHGLM was demonstrated. Next, as a precursor to using the PHGLM for DIF identification, a simulation was conducted to compare estimation of item and person latent trait parameters using HLM 5 and PARSCALE software. The resulting PHGLM and IRT parameter estimates were comparable. Last, a simulation was conducted that compared the performance of PHGLM with that of the generalized Mantel-Haenszel statistic for DIF identification. Both approaches performed similarly. Benefits and limitations of using PHGLM for DIF identification are presented. Index terms: hierarchical linear modeling, item response theory, polytomous items, parameter estimation, differential item functioning, attitude measurement.

Type of Medium: Online Resource

ISSN: 0146-6216 , 1552-3497

URL: Article

DOI: 10.1177/0146621605279867

Language: English

Publisher: SAGE Publications

Publication Date: 2006

detail.hit.zdb_id: 224215-1

detail.hit.zdb_id: 2002941-X

SSG: 5,2

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Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Horwitz, Leora I. ; Thaweethai, Tanayott ; Brosnahan, Shari B. ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS ONE Vol. 18, No. 6 ( 2023-6-23), p. e0286297-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 6 ( 2023-6-23), p. e0286297-

Abstract: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. Methods RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. Discussion RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options. Registration NCT05172024 .

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0286297

DOI: 10.1371/journal.pone.0286297.g001

DOI: 10.1371/journal.pone.0286297.t001

DOI: 10.1371/journal.pone.0286297.t002

DOI: 10.1371/journal.pone.0286297.t003

DOI: 10.1371/journal.pone.0286297.t004

DOI: 10.1371/journal.pone.0286297.s001

DOI: 10.1371/journal.pone.0286297.s002

DOI: 10.1371/journal.pone.0286297.s003

DOI: 10.1371/journal.pone.0286297.s004

DOI: 10.1371/journal.pone.0286297.s005

DOI: 10.1371/journal.pone.0286297.s006

DOI: 10.1371/journal.pone.0286297.s007

DOI: 10.1371/journal.pone.0286297.s008

DOI: 10.1371/journal.pone.0286297.s009

DOI: 10.1371/journal.pone.0286297.s010

DOI: 10.1371/journal.pone.0286297.s011

DOI: 10.1371/journal.pone.0286297.s012

DOI: 10.1371/journal.pone.0286297.s013

DOI: 10.1371/journal.pone.0286297.s014

DOI: 10.1371/journal.pone.0286297.r001

DOI: 10.1371/journal.pone.0286297.r002

DOI: 10.1371/journal.pone.0286297.r003

DOI: 10.1371/journal.pone.0286297.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2267670-3

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Racial/ethnic disparities in sleep health and health care: importance of the sociocultural context

Williams, Natasha J. ; Grandner, Michael A. ; Snipes, Shedra A. ; [et al.]

Elsevier BV ; 2015

In: Sleep Health Vol. 1, No. 1 ( 2015-03), p. 28-35

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In: Sleep Health, Elsevier BV, Vol. 1, No. 1 ( 2015-03), p. 28-35

Type of Medium: Online Resource

ISSN: 2352-7218

URL: Article

DOI: 10.1016/j.sleh.2014.12.004

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 2813299-3

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Doctor-patient sleep discussions for US adults: results from the SHADES study

Klingman, Karen J. ; Williams, Natasha J ; Perlis, Michael L. ; [et al.]

Elsevier BV ; 2019

In: Sleep Health Vol. 5, No. 6 ( 2019-12), p. 658-665

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In: Sleep Health, Elsevier BV, Vol. 5, No. 6 ( 2019-12), p. 658-665

Type of Medium: Online Resource

ISSN: 2352-7218

URL: Article

DOI: 10.1016/j.sleh.2019.07.004

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2813299-3

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Eliminating Sleep Health Disparities and Achieving Health Equity: Seven Areas for Action in the Behavioral Sleep Medicine Community

Hughes, Abbey J. ; Gunn, Heather ; Siengsukon, Catherine ; [et al.]

Informa UK Limited ; 2023

In: Behavioral Sleep Medicine Vol. 21, No. 5 ( 2023-09-03), p. 633-645

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In: Behavioral Sleep Medicine, Informa UK Limited, Vol. 21, No. 5 ( 2023-09-03), p. 633-645

Type of Medium: Online Resource

ISSN: 1540-2002 , 1540-2010

URL: Article

DOI: 10.1080/15402002.2022.2149523

Language: English

Publisher: Informa UK Limited

Publication Date: 2023

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