In:
Annual Review of Pharmacology and Toxicology, Annual Reviews, Vol. 45, No. 1 ( 2005-09-22), p. 725-750
Abstract:
▪ Abstract The complete sequencing of the human genome is generating many novel targets for drug discovery. Understanding the pathophysiological roles of these putative targets and assessing their suitability for therapeutic intervention has become the major hurdle for drug discovery efforts. The dual-specificity phosphatases (DSPases), which dephosphorylate serine, threonine, and tyrosine residues in the same protein substrate, have important roles in multiple signaling pathways and appear to be deregulated in cancer and Alzheimer's disease. We examine the potential of DSPases as new molecular therapeutic targets for the treatment of human disease.
Type of Medium:
Online Resource
ISSN:
0362-1642
,
1545-4304
DOI:
10.1146/pharmtox.2005.45.issue-1
DOI:
10.1146/annurev.pharmtox.45.120403.100040
Language:
English
Publisher:
Annual Reviews
Publication Date:
2005
detail.hit.zdb_id:
1474461-2
SSG:
15,3
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