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  • 1
    Online Resource
    Online Resource
    Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial
    Springer Science and Business Media LLC ; 2023
    In:  BMC Medicine Vol. 21, No. 1 ( 2023-10-09)
    Details
    In: BMC Medicine, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2023-10-09)
    Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the findings from a multicenter, randomized, double-blind, placebo-controlled phase 3 clinical trial, which was designed to assess the efficacy and safety of a novel DPP-4 inhibitor fotagliptin in treatment-naive patients with T2DM. Methods Patients with T2DM were randomized to receive fotagliptin ( n  = 230), alogliptin ( n  = 113) or placebo ( n  = 115) at a 2:1:1 ratio for 24 weeks of double-blind treatment period, followed by an open-label treatment period, making up a total of 52 weeks. The primary efficacy endpoint was to determine the superiority of fotagliptin over placebo in the change of HbA1c from baseline to Week 24. All serious or significant adverse events were recorded. Results After 24 weeks, mean decreases in HbA1c from baseline were -0.70% for fotagliptin, -0.72% for alogliptin and -0.26% for placebo. Estimated mean treatment differences in HbA1c were -0.44% (95% confidence interval [CI]: -0.62% to -0.27%) for fotagliptin versus placebo, and -0.46% (95% CI: -0.67% to -0.26%) for alogliptin versus placebo, and 0.02% (95%CI: -0.16% to 0.19%; upper limit of 95%CI  〈  margin of 0.4%) for fotagliptin versus alogliptin. So fotagliptin was non-inferior to alogliptin. Compared with subjects with placebo (15.5%), significantly more patients with fotagliptin (37.0%) and alogliptin (35.5%) achieved HbA1c  〈  7.0% after 24 weeks of treatment. During the whole 52 weeks of treatment, the overall incidence of hypoglycemia was low for both of the fotagliptin and alogliptin groups (1.0% each). No drug-related serious adverse events were observed in any treatment group. Conclusions In summary, the study demonstrated improvement in glycemic control and a favorable safety profile for fotagliptin in treatment-naive patients with T2DM. Trial registration ClinicalTrail.gov NCT05782192.
    Type of Medium: Online Resource
    ISSN: 1741-7015
    URL: Article
    DOI: 10.1186/s12916-023-03089-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2131669-7
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  • 2
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    Online Resource
    Expansion of EYM amplitudes in gauge invariant vector space *
    IOP Publishing ; 2020
    In:  Chinese Physics C Vol. 44, No. 12 ( 2020-12-01), p. 123104-
    Details
    In: Chinese Physics C, IOP Publishing, Vol. 44, No. 12 ( 2020-12-01), p. 123104-
    Abstract: Motivated by the problem of expanding the single-trace tree-level amplitude of Einstein-Yang-Mills theory to the BCJ basis of Yang-Mills amplitudes, we present an alternative expansion formula in gauge invariant vector space. Starting from a generic vector space consisting of polynomials of momenta and polarization vectors, we define a new sub-space as a gauge invariant vector space by imposing constraints on the gauge invariant conditions. To characterize this sub-space, we compute its dimension and construct an explicit gauge invariant basis from it. We propose an expansion formula in this gauge invariant basis with expansion coefficients being linear combinations of the Yang-Mills amplitude, manifesting the gauge invariance of both the expansion basis and coefficients. With the help of quivers, we compute the expansion coefficients via differential operators and demonstrate the general expansion algorithm using several examples.
    Type of Medium: Online Resource
    ISSN: 1674-1137 , 2058-6132
    URL: Article
    DOI: 10.1088/1674-1137/abb4ce
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2491278-5
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  • 3
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    Online Resource
    Petrogenesis and Mineralization of Two‐Stage A‐Type Granites in Jiuyishan, South China: Constraints from Whole‐rock Geochemistry, Mineral Composition and Zircon U‐Pb‐Hf Isotopes
    Wiley ; 2019
    In:  Acta Geologica Sinica - English Edition Vol. 93, No. 4 ( 2019-08), p. 874-900
    Details
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 93, No. 4 ( 2019-08), p. 874-900
    Abstract: The Jiuyishan complex massif, located in the northern section of the Nanling region, is a combination of five plutons, namely, the Xuehuading, Jinjiling, Pangxiemu, Shaziling and Xishan plutons. Whole‐rock geochemistry, mineral electron microprobe analysis, zircon U‐Pb dating and Hf isotope analysis were carried out for the Jinjiling and Pangxiemu plutons. The zircon U‐Pb dating yields weighted mean ages of 152.9±0.9 Ma for the Jinjiling pluton and 151.7±1.5 Ma for the Pangxiemu pluton, with a narrow gap between them. The Jinjiling and Pangxiemu plutons both have geochemical characteristics of high SiO 2 , Al 2 O 3 , Na 2 O, K 2 O and low TiO 2 , MgO, CaO, P 2 O 5 contents, with intense depletionS in Sr, Ba, Ti, Eu and enrichments in Ga, FeO T and HFSE, and these characteristics reflect an A‐type affinity. From the Jinjiling to the Pangxiemu plutons, the mineral composition of mica changes from lepidomelane to zinnwaldite, with increases in F, Li 2 O and Rb 2 O contents. The mineral composition of zircon changes from low Zr/Hf to high Zr/Hf, with increasing HfO 2 , P 2 O 5 and UO 2 +ThO 2 +Y 2 O 3 contents. The mineral compositions of feldspar indicate that the Pangxiemu pluton contains more alkali feldspar than the Jinjiling pluton. The whole‐rock geochemistry and mineral compositions reveal a higher degree of differentiation for the Pangxiemu pluton. The nearly uniform ε Hf ( t ) indicates the same source region for the two plutons: both were derived from partial melting of the lower crust, with small contributions of mantle materials. In addition, higher F, lower Nb/Ta and Zr/Hf ratios in the Pangxiemu Pluton suggest a closer relationship with the rare metal mineralization than for the Jinjiling pluton.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    URL: Article
    DOI: 10.1111/acgs.v93.4
    DOI: 10.1111/1755-6724.13864
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2420386-5
    SSG: 6,25
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