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  • 1
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 54, No. 9 ( 2023-09), p. 2241-2250
    Abstract: It is unclear whether patients with different stroke/transient ischemic attack etiologies benefit differently from gene-directed dual antiplatelet therapy. This study explored the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in transient ischemic attack or minor stroke with different causes in the CHANCE-2 trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events-II). METHODS: This was a prespecified analysis of the CHANCE-2 trial, which enrolled 6412 patients with minor stroke or transient ischemic attack who carried CYP2C19 loss-of-function alleles. Patients with centralized evaluation of TOAST (Trial of ORG 10172 in Acute Stroke Treatment) classification of large-artery atherosclerosis, small-vessel occlusion, and stroke of undetermined cause were included. The primary efficacy outcome was new stroke, and the primary safety outcome was severe or moderate bleeding, both within 90 days. Cox proportional hazards models were used to assess the interaction of TOAST classification with the effects of dual antiplatelet therapy with ticagrelor-aspirin versus clopidogrel-aspirin. RESULTS: A total of 6336 patients were included in this study. In patients administered ticagrelor-aspirin and clopidogrel-aspirin, respectively, stroke recurred in 85 (9.8%) and 88 (10.7%) patients with large-artery atherosclerosis (hazard ratio, 0.86 [95% CI, 0.63–1.18]; P =0.34); 32 (3.6%) and 61 (7.0%) patients with small-vessel occlusion (hazard ratio, 0.51 [95% CI, 0.33–0.79]; P =0.002); and 68 (4.8%) and 87 (5.9%) patients with stroke of undetermined cause (hazard ratio, 0.80 [95% CI, 0.58–1.10]; P =0.17), with P =0.08 for the treatment×cause subtype interaction effect. There were no significant differences in severe or moderate bleeding events in patients with different cause and different treatment. CONCLUSIONS: In this prespecified analysis of the CHANCE-2 trial, the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in preventing new stroke were consistent in patients with different causes. The influence of stroke cause on benefit of gene-guided antiplatelet therapy should be explored by further trials. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04078737.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1467823-8
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  • 2
    Online Resource
    Online Resource
    Angle Publishing Co., Ltd. ; 2023
    In:  電腦學刊 Vol. 34, No. 4 ( 2023-08), p. 127-143
    In: 電腦學刊, Angle Publishing Co., Ltd., Vol. 34, No. 4 ( 2023-08), p. 127-143
    Abstract: 〈p〉In this study, we investigate the application of a deep learning framework for the recognition of pig vocalizations. This innovative approach aims to actively monitor and evaluate the diverse states of pigs, with an overarching objective to improve the efficiency of pig farming through prompt identification and resolution of issues. In our comprehensive data collection effort, we carefully gathered a vast assortment of vocal samples from 50 pigs, representative of four distinct states: normal, frightened, coughing, and sneezing. We then meticulously analyzed this vocal data using Mel Frequency Cepstral Coefficients (MFCC). For accurate recognition of pig vocalizations, we devised a fusion model that combines the strengths of Residual Networks (ResNet) and Long Short-Term Memory Networks (LSTM). This model was subsequently tailored, trained, and optimized to meet our specific requirements. Upon rigorous evaluation, we found our model to exhibit exceptional performance in pig vocal recognition tasks, thereby reinforcing the potential of deep learning methodologies in revolutionizing the livestock industry. This research notably underscores the potential of deploying efficient real-time health monitoring systems, offering a promising avenue towards modernizing livestock management practices.〈/p〉 〈p〉 〈/p〉
    Type of Medium: Online Resource
    ISSN: 1991-1599 , 1991-1599
    Uniform Title: Animal Vocal Recognition-Based Breeding Tracking and Disease Warning
    Language: Unknown
    Publisher: Angle Publishing Co., Ltd.
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Angle Publishing Co., Ltd. ; 2023
    In:  電腦學刊 Vol. 34, No. 4 ( 2023-08), p. 203-213
    In: 電腦學刊, Angle Publishing Co., Ltd., Vol. 34, No. 4 ( 2023-08), p. 203-213
    Abstract: 〈p〉Crack detection is an important aspect to measure the structural stability of buildings. At present, the detection of building cracks still mainly adopts manual detection methods, which rely too much on personal experience, low detection accuracy, and consume a lot of manpower and material resources. In response to this issue, we use an end-to-end method to predict the pixel by pixel crack segmentation DeepCrack network model, and use CRF and GF methods to fuse the final prediction results. Firstly, the ResNet34 model was pre trained on the PASCAL VOC2007 dataset. The DeepCrack + CRF + GF model was used for training, and the Adaptive Threshold method was used to partition and binarize the training results. Finally, the constructed wall crack detection model achieved an AP value of 89.12%, accuracy and recall rates of 83.96%, 88.47%, and IoU value of 85.80%. On the premise of ensuring detection accuracy, the model is only 47 MB, making it possible to deploy it on embedded devices. It can be used in practical engineering applications to build an intelligent building crack detection system, saving a lot of manpower and resources.〈/p〉 〈p〉 〈/p〉
    Type of Medium: Online Resource
    ISSN: 1991-1599 , 1991-1599
    Uniform Title: Intelligent Crack Detection and Analysis of Building Walls Based on DeepCrack Network
    Language: Unknown
    Publisher: Angle Publishing Co., Ltd.
    Publication Date: 2023
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  • 4
    In: Journal of Cosmology and Astroparticle Physics, IOP Publishing, Vol. 2023, No. 10 ( 2023-10-01), p. 022-
    Abstract: The Jiangmen Underground Neutrino Observatory (JUNO), the first multi-kton liquid scintillator detector, which is under construction in China, will have a unique potential to perform a real-time measurement of solar neutrinos well below the few MeV threshold typical of Water Cherenkov detectors. JUNO's large target mass and excellent energy resolution are prerequisites for reaching unprecedented levels of precision. In this paper, we provide estimation of the JUNO sensitivity to 7 Be, pep , and CNO solar neutrinos that can be obtained via a spectral analysis above the 0.45 MeV threshold. This study is performed assuming different scenarios of the liquid scintillator radiopurity, ranging from the most optimistic one corresponding to the radiopurity levels obtained by the Borexino experiment, up to the minimum requirements needed to perform the neutrino mass ordering determination with reactor antineutrinos — the main goal of JUNO. Our study shows that in most scenarios, JUNO will be able to improve the current best measurements on 7 Be, pep , and CNO solar neutrino fluxes. We also perform a study on the JUNO capability to detect periodical time variations in the solar neutrino flux, such as the day-night modulation induced by neutrino flavor regeneration in Earth, and the modulations induced by temperature changes driven by helioseismic waves.
    Type of Medium: Online Resource
    ISSN: 1475-7516
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2104147-7
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  • 5
    In: Pest Management Science, Wiley, Vol. 77, No. 10 ( 2021-10), p. 4375-4382
    Abstract: Wheat powdery mildew is a worldwide fungal disease and one of the main diseases harming wheat production. Bacillus subtilis is a vital biocontrol bacteria with broad‐spectrum antimicrobial activity. In this study, we systematically studied the control effect of B. subtilis on wheat powdery mildew. RESULTS The control efficiency of 4 × 10 5  CFU ml −1 B. subtilis on wheat leaves was 71.75% in vitro and 70.31% in a pot experiment. Application of 4 × 10 5  CFU ml −1 B. subtilis significantly inhibited spore germination (spore germination rate of 22.23%) and increased appressorium deformity (appressorium deformity rate of 69.33%). This was significantly different from the results in the sterile water treatment. Through transcriptome sequencing analysis, we found that differentially expressed genes were mainly enriched in the biosynthesis and metabolism of amino acids (including phenylalanine), carbon metabolism, the pentose phosphate pathway and other pathways. In particular, the plant hormone signal pathway gene nonexpressor of pathogenesis‐related genes 1 ( NPR1 ) was significantly upregulated. CONCLUSION B. subtilis at concentrations of 4 × 10 5  CFU ml −1 had a significant control effect on wheat powdery mildew and can inhibit germination of the conidial germ tubes and the normal development of appressorium. B. subtilis may induce disease resistance in wheat to control wheat powdery mildew, and this effect is related to the salicylic acid‐dependent signal pathway. © 2021 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2023
    In:  Genetic Epidemiology Vol. 47, No. 2 ( 2023-03), p. 185-197
    In: Genetic Epidemiology, Wiley, Vol. 47, No. 2 ( 2023-03), p. 185-197
    Abstract: In genome‐wide association studies (GWAS) for thousands of phenotypes in biobanks, most binary phenotypes have substantially fewer cases than controls. Many widely used approaches for joint analysis of multiple phenotypes produce inflated type I error rates for such extremely unbalanced case‐control phenotypes. In this research, we develop a method to jointly analyze multiple unbalanced case‐control phenotypes to circumvent this issue. We first group multiple phenotypes into different clusters based on a hierarchical clustering method, then we merge phenotypes in each cluster into a single phenotype. In each cluster, we use the saddlepoint approximation to estimate the p  value of an association test between the merged phenotype and a single nucleotide polymorphism (SNP) which eliminates the issue of inflated type I error rate of the test for extremely unbalanced case‐control phenotypes. Finally, we use the Cauchy combination method to obtain an integrated p  value for all clusters to test the association between multiple phenotypes and a SNP. We use extensive simulation studies to evaluate the performance of the proposed approach. The results show that the proposed approach can control type I error rate very well and is more powerful than other available methods. We also apply the proposed approach to phenotypes in category IX (diseases of the circulatory system) in the UK Biobank. We find that the proposed approach can identify more significant SNPs than the other viable methods we compared with.
    Type of Medium: Online Resource
    ISSN: 0741-0395 , 1098-2272
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492643-X
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  • 7
    Online Resource
    Online Resource
    IOP Publishing ; 2021
    In:  Journal of Physics: Conference Series Vol. 1920, No. 1 ( 2021-05-01), p. 012074-
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 1920, No. 1 ( 2021-05-01), p. 012074-
    Abstract: In order to improve the precision of radar target positioning, the phased array frequency modulated continuous wave (FMCW) radar system based on single-send and multiple-receive is proposed for low altitude, slow speed, small Unmanned Aerial Vehicle (LSS-UAV) target. The much lower-cost passive electronically scanned array (PESA) radar technology has been employed for the azimuth electronically scanning. In addition, wide beam scanning beam of elevation direction is used to further expand the range of space coverage. Phase-comparison method is adopted to high-precision angle measurement of elevation direction in interferometer angle measurement system with dual distributed receivers. As a result, the novel radar system possesses the abilities of Doppler velocity measurement and linear FMCW distance measurement, as well as the high precision angle measurement at the same time. It can provide long distance, wide range, all-weather/time detection accurate target location information for optical system and electronic interception system to detect LSS-UAV targets for some more cost-sensitive applications in the homeland security market.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2166409-2
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  • 8
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2015
    In:  Chemical Research in Chinese Universities Vol. 31, No. 3 ( 2015-6), p. 401-405
    In: Chemical Research in Chinese Universities, Springer Science and Business Media LLC, Vol. 31, No. 3 ( 2015-6), p. 401-405
    Type of Medium: Online Resource
    ISSN: 1005-9040 , 2210-3171
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2238839-4
    SSG: 6,25
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  • 9
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Metallurgical and Materials Transactions B
    In: Metallurgical and Materials Transactions B, Springer Science and Business Media LLC
    Type of Medium: Online Resource
    ISSN: 1073-5615 , 1543-1916
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2037524-4
    SSG: 19,1
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  • 10
    In: The Journal of Clinical Hypertension, Wiley, Vol. 21, No. 10 ( 2019-10), p. 1534-1541
    Abstract: Using data from the Blood Pressure and Clinical Outcome in TIA or Ischemic Stroke (BOSS) study, we aim to test the applicability and feasibility of stroke secondary prevention recommendations from the 2017 American College of Cardiology/American Heart Association guideline. Patients were categorized based on their blood pressure (BP) status at 3 months. The nonhypertension group was defined as those without a diagnosis of hypertension. The other patients were further divided into three subgroups according to office BP measured at 3‐month visit (BP 〈 130/80, 130‐139/80‐89, and ≥140/90 mm Hg). The primary outcome was any stroke within one year. The associations between BP status and 1‐year prognosis (recurrent stroke, recurrent stroke/TIA, and poor functional outcome [modified Rankin scale score 3‐6]) were estimated. Among 2341 IS/TIA patients, additional 1056 patients were classified as uncontrolled hypertension at the 90‐day visit according to the new guidelines. Adjusted hazard/odds ratios (95% confidence intervals [CI] ) for recurrent stroke in BP 〈 130/80, 130‐139/80‐89, and ≥140/90 compared with nonhypertension group were 2.42 (95% CI: 0.87‐6.76), and 4.30 (95% CI: 1.73‐10.70), respectively. The prevalence of hypertension and uncontrolled BP among BOSS study population was substantially higher based on the new guidelines. BP of 130‐139/80‐89 did not show the worsened clinical outcomes compared with people without hypertension. Our study adds to the growing uncertainty about secondary prevention BP goal for IS/TIA patients.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2058690-5
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