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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, Daniel J. ; Abdel-Aziz, Amal Kamal ; Abdelfatah, Sara ; [et al.]

Informa UK Limited ; 2021

In: Autophagy Vol. 17, No. 1 ( 2021-01-02), p. 1-382

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In: Autophagy, Informa UK Limited, Vol. 17, No. 1 ( 2021-01-02), p. 1-382

Type of Medium: Online Resource

ISSN: 1554-8627 , 1554-8635

URL: Article

DOI: 10.1080/15548627.2020.1797280

Language: English

Publisher: Informa UK Limited

Publication Date: 2021

detail.hit.zdb_id: 2262043-6

SSG: 12

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The neutrophil‐to‐lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90‐day mortality in non‐cirrhotic chronic severe hepatitis

Dong, Fu Chen ; Tan, Wen Ting ; Wang, Xian Bo ; [et al.]

Wiley ; 2022

In: Journal of Digestive Diseases Vol. 23, No. 10 ( 2022-10), p. 587-596

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In: Journal of Digestive Diseases, Wiley, Vol. 23, No. 10 ( 2022-10), p. 587-596

Abstract: To investigate the relationship between systemic inflammatory response and short‐term mortality in patients with non‐cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil‐to‐lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet‐to lymphocyte ratio (PLR), and monocyte‐to‐lymphocyte ratio (MLR). Methods Data were collected from two prospectively enrolled CATCH‐LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90‐day liver transplant (LT)‐free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90‐day LT‐free mortality. Kaplan–Meier method was used to estimate the 90‐year LT‐free survival. Results The prevalence of CSH was 20.5% (226/1103). The 28‐day and 90‐day LT‐free mortality rates were 17.7% and 26.1%, respectively, for patients with non‐cirrhotic CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90‐day LT‐free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection. Conclusions NLR may be an independent risk factor for 90‐day LT‐free mortality in patients with non‐cirrhotic chronic liver disease. A NLR of 2.9 as the cut‐off value can be used to predict disease aggravation in CSH patients without infection.

Type of Medium: Online Resource

ISSN: 1751-2972 , 1751-2980

URL: Issue

URL: Article

DOI: 10.1111/cdd.v23.10

DOI: 10.1111/1751-2980.13143

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2317117-0

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Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial

Xu, Mingtong ; Sun, Kan ; Xu, Wenjie ; [et al.]

Springer Science and Business Media LLC ; 2023

In: BMC Medicine Vol. 21, No. 1 ( 2023-10-09)

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In: BMC Medicine, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2023-10-09)

Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the findings from a multicenter, randomized, double-blind, placebo-controlled phase 3 clinical trial, which was designed to assess the efficacy and safety of a novel DPP-4 inhibitor fotagliptin in treatment-naive patients with T2DM. Methods Patients with T2DM were randomized to receive fotagliptin ( n = 230), alogliptin ( n = 113) or placebo ( n = 115) at a 2:1:1 ratio for 24 weeks of double-blind treatment period, followed by an open-label treatment period, making up a total of 52 weeks. The primary efficacy endpoint was to determine the superiority of fotagliptin over placebo in the change of HbA1c from baseline to Week 24. All serious or significant adverse events were recorded. Results After 24 weeks, mean decreases in HbA1c from baseline were -0.70% for fotagliptin, -0.72% for alogliptin and -0.26% for placebo. Estimated mean treatment differences in HbA1c were -0.44% (95% confidence interval [CI]: -0.62% to -0.27%) for fotagliptin versus placebo, and -0.46% (95% CI: -0.67% to -0.26%) for alogliptin versus placebo, and 0.02% (95%CI: -0.16% to 0.19%; upper limit of 95%CI 〈 margin of 0.4%) for fotagliptin versus alogliptin. So fotagliptin was non-inferior to alogliptin. Compared with subjects with placebo (15.5%), significantly more patients with fotagliptin (37.0%) and alogliptin (35.5%) achieved HbA1c 〈 7.0% after 24 weeks of treatment. During the whole 52 weeks of treatment, the overall incidence of hypoglycemia was low for both of the fotagliptin and alogliptin groups (1.0% each). No drug-related serious adverse events were observed in any treatment group. Conclusions In summary, the study demonstrated improvement in glycemic control and a favorable safety profile for fotagliptin in treatment-naive patients with T2DM. Trial registration ClinicalTrail.gov NCT05782192.

Type of Medium: Online Resource

ISSN: 1741-7015

URL: Article

DOI: 10.1186/s12916-023-03089-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2131669-7

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Genomes of the rice pest brown planthopper and its endosymbionts reveal complex complementary contributions for host adaptation

Xue, Jian ; Zhou, Xin ; Zhang, Chuan-Xi ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Genome Biology Vol. 15, No. 12 ( 2014-12)

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In: Genome Biology, Springer Science and Business Media LLC, Vol. 15, No. 12 ( 2014-12)

Type of Medium: Online Resource

ISSN: 1474-760X

URL: Article

DOI: 10.1186/s13059-014-0521-0

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2040529-7

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Effects of integrative Chinese and Western medicine on arterial oxygen saturation in patients with severe acute respiratory syndrome

Bao-yan, Liu ; Jing-qing, Hu ; Yan-ming, Xie ; [et al.]

Springer Science and Business Media LLC ; 2004

In: Chinese Journal of Integrative Medicine Vol. 10, No. 2 ( 2004-6), p. 117-122

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In: Chinese Journal of Integrative Medicine, Springer Science and Business Media LLC, Vol. 10, No. 2 ( 2004-6), p. 117-122

Type of Medium: Online Resource

ISSN: 1672-0415 , 1993-0402

URL: Article

DOI: 10.1007/BF02836381

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2004

detail.hit.zdb_id: 2325040-9

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The functional and structural alterations of the striatum in chronic spontaneous urticaria

Wang, Yuming ; Fang, Ji-Liang ; Cui, Bingnan ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Scientific Reports Vol. 8, No. 1 ( 2018-01-29)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-01-29)

Abstract: The brain has long been known to be the regulation center of itch, but the neuropathology of chronic itch, such as chronic spontaneous urticaria (CSU), remains unclear. Thus, we aimed to explore the brain areas involved in the pathophysiology of CSU in hopes that our results may provide valuable insights into the treatment of chronic itch conditions. 40 CSU patients and 40 healthy controls (HCs) were recruited. Urticaria activity scores 7 (UAS7) were collected to evaluate patient’s clinical symptoms. Amplitude of low frequency fluctuations (ALFF), voxel-based morphometry (VBM), and seed-based resting-state functional connectivity (rs-FC) analysis were used to assess brain activity and related plasticity. Compared with HCs, CSU patients exhibited 1) higher ALFF values in the right ventral striatum / putamen, which were positively associated with clinical symptoms as measured by UAS7; 2) gray matter volume (GMV) increase in the right ventral striatum and putamen; and 3) decreased rs-FC between the right ventral striatum and the right occipital cortex and between the right putamen and the left precentral gyrus. Using multiple-modality brain imaging tools, we demonstrated the dysfunction of the striatum in CSU. Our results may provide valuable insights into the neuropathology and development of chronic itch.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-018-19962-2

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2615211-3

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Career choice and influential factors among medical students majoring in psychiatry in China

Zhang, Ying-Jian ; Yuan, Kai ; Chang, Su-Hua ; [et al.]

Springer Science and Business Media LLC ; 2021

In: BMC Medical Education Vol. 21, No. 1 ( 2021-12)

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In: BMC Medical Education, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)

Abstract: The undergraduate program of psychiatry has been widely established in recent years to improve the education and recruitment of psychiatrists in China. We aim to investigate the career choice of medical students majoring in psychiatry in China and the influential factors. Method This multicenter study was conducted in 26 medical schools in China from May to October of 2019. Participants included 4610 medical students majoring in psychiatry and 3857 medical students majoring in clinical medicine. Multivariable logistic regression was used to investigate the influential factors of students’ choices of psychiatry at matriculation and as a career. Results 44.08% of psychiatry majored students gave psychiatry as a first choice at matriculation, and 56.67% of them would choose psychiatry as a career, which was in sharp contrast to the proportion of clinical medicine majored students who would choose psychiatry as a career (0.69%). Personal interest (59.61%), suggestions from family members (27.96%), and experiencing mental problems (23.19%) were main reasons for choosing psychiatry major at matriculation. Personal interest (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 1.87–2.40), experiencing a psychiatry clerkship (OR = 1.99, 95% CI = 1.28–3.08), being female (OR = 1.50, 95% CI = 1.30–1.68), experiencing mental problems (OR = 1.33, 95% CI = 1.28–1.56), and suggestions from family members (OR = 1.25, 95% CI = 1.08–1.46) correlated positively with students’ choice of psychiatry as career. Students who lacked psychiatry knowledge (OR = 0.49, 95% CI = 0.29–0.85) or chose psychiatry because of lower admission scores (OR = 0.80, 95% CI = 0.63–0.97) were less likely to choose psychiatry as a career. Conclusion More than half of psychiatry majored medical school students planned to choose psychiatry as their career, whereas very few students in the clinic medicine major would make this choice. Increasing students’ interest in psychiatry, strengthening psychiatry clerkships, and popularizing psychiatric knowledge are modifiable factors to increase the psychiatry career intention. The extent to which medical students’ attitudes toward psychiatry can be changed through medical school education and greater exposure to psychiatry will need further investigation.

Type of Medium: Online Resource

ISSN: 1472-6920

URL: Article

DOI: 10.1186/s12909-021-02622-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2044473-4

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Transcriptome Analysis of the Brown Planthopper Nilaparvata lugens

Xue, Jian ; Bao, Yan-Yuan ; Li, Bao-ling ; [et al.]

Public Library of Science (PLoS) ; 2010

In: PLoS ONE Vol. 5, No. 12 ( 2010-12-6), p. e14233-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 5, No. 12 ( 2010-12-6), p. e14233-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0014233

DOI: 10.1371/journal.pone.0014233.g001

DOI: 10.1371/journal.pone.0014233.g002

DOI: 10.1371/journal.pone.0014233.g003

DOI: 10.1371/journal.pone.0014233.g004

DOI: 10.1371/journal.pone.0014233.g005

DOI: 10.1371/journal.pone.0014233.g006

DOI: 10.1371/journal.pone.0014233.g007

DOI: 10.1371/journal.pone.0014233.g008

DOI: 10.1371/journal.pone.0014233.t001

DOI: 10.1371/journal.pone.0014233.s001

DOI: 10.1371/journal.pone.0014233.s002

DOI: 10.1371/journal.pone.0014233.s003

DOI: 10.1371/journal.pone.0014233.s004

DOI: 10.1371/journal.pone.0014233.s005

DOI: 10.1371/journal.pone.0014233.s006

DOI: 10.1371/journal.pone.0014233.s007

DOI: 10.1371/journal.pone.0014233.s008

DOI: 10.1371/journal.pone.0014233.s009

DOI: 10.1371/journal.pone.0014233.s010

DOI: 10.1371/journal.pone.0014233.s011

DOI: 10.1371/journal.pone.0014233.s012

DOI: 10.1371/journal.pone.0014233.s013

DOI: 10.1371/journal.pone.0014233.s014

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2010

detail.hit.zdb_id: 2267670-3

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Main-chain liquid-crystalline ionomers bearing potassium sulfonate groups

Meng, Fan-Bao ; Zhang, Bao-Yan ; Xu, Ye ; [et al.]

Wiley ; 2005

In: Journal of Applied Polymer Science Vol. 96, No. 6 ( 2005-06-15), p. 2021-2026

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In: Journal of Applied Polymer Science, Wiley, Vol. 96, No. 6 ( 2005-06-15), p. 2021-2026

Type of Medium: Online Resource

ISSN: 0021-8995 , 1097-4628

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/app.v96:6

DOI: 10.1002/(ISSN)1097-4628

DOI: 10.1002/app.21655

Language: English

Publisher: Wiley

Publication Date: 2005

detail.hit.zdb_id: 1491105-X

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Etiology and clinical features of children with bronchiectasis in China: A 10‐year multicenter retrospective study

Wang, Hao ; Xu, Bao‐ping ; Bao, Yan‐min ; [et al.]

Wiley ; 2023

In: The Clinical Respiratory Journal Vol. 17, No. 9 ( 2023-09), p. 841-850

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In: The Clinical Respiratory Journal, Wiley, Vol. 17, No. 9 ( 2023-09), p. 841-850

Abstract: The current study aims to investigate the etiology spectrum and the clinical characteristics of bronchiectasis in Chinese children. Methods The study is designed as a multicenter retrospective study. 193 cases were enrolled in 13 centers in China between 2008 and 2017. The inclusive cases must meet the clinical as well as the HRCT criteria. Only if both two radiologists confirmed the diagnosis, the case could be enrolled. The cases that could not provide clinical and imageology data were excluded. The data were entered into the specialized system and then analyzed. Results One hundred sixty‐nine cases (87%) were found to have the underlying etiology. Post‐infective (46%), primary immunodeficiency (14%), and PCD (13%) were the common causes. All cases came from 28 provinces in Mainland China. The median age of symptom onset was 5.8 (2.0, 8.9) years. The median age of diagnosis was 8.4 (4.5, 11.6) years. The main symptoms were cough, sputum expectoration, and fever during the exacerbation. Nineteen percent of patients suffered from limited exercise tolerance. Clubbing was found in 17% of cases. Nearly 30% of patients presented growth limitations. On the HRCT findings, 126 cases had diffused bronchiectasis, and bilateral involvement was found in 94 cases. The lower lobes and right middle lobes were most commonly involved. Approximately 30% of cultures of sputum and bronchoalveolar lavage were positive. Conclusion A majority of cases could be found the underlying etiology. Post‐infective, primary immunodeficiency, and PCD were the most common causes. Some clinical figures might indicate a specific etiology.

Type of Medium: Online Resource

ISSN: 1752-6981 , 1752-699X

URL: Issue

URL: Article

DOI: 10.1111/crj.v17.9

DOI: 10.1111/crj.13630

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2442214-9

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