In:
Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-10-14)
Abstract:
Atrial fibrillation (AF) is the most frequent arrythmia managed in clinical practice. Several mechanisms have been proposed to contribute to the occurrence and persistence of AF, in which oxidative stress plays a non-negligible role. The endocannabinoid system (ECS) is involved in a variety physiological and pathological processes. Cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R) are expressed in the heart, and studies have shown that activating CB2R has a protective effect on the myocardium. However, the role of CB2R in AF is unknown. Materials and methods Angiotensin II (Ang II)-infused mice were treated with the CB2R agonist AM1241 intraperitoneally for 21 days. Atrial structural remodeling, AF inducibility, electrical transmission, oxidative stress and fibrosis were measured in mice. Results The susceptibility to AF and the level of oxidative stress were increased significantly in Ang II-infused mice. In addition, nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2), NOX4, and oxidized Ca 2+ /calmodulin-dependent protein kinase II (ox-CaMKII) were highly expressed. More importantly, treatment with AM1241 activated CB2R, resulting in a protective effect. Conclusion The present study demonstrates that pharmacological activation of CB2R exerts a protective effect against AF via a potential NOX/CaMKII mechanism. CB2R is a potential therapeutic target for AF.
Type of Medium:
Online Resource
ISSN:
2297-055X
DOI:
10.3389/fcvm.2022.968014
DOI:
10.3389/fcvm.2022.968014.s001
DOI:
10.3389/fcvm.2022.968014.s002
DOI:
10.3389/fcvm.2022.968014.s003
DOI:
10.3389/fcvm.2022.968014.s004
DOI:
10.3389/fcvm.2022.968014.s005
DOI:
10.3389/fcvm.2022.968014.s006
DOI:
10.3389/fcvm.2022.968014.s007
DOI:
10.3389/fcvm.2022.968014.s008
DOI:
10.3389/fcvm.2022.968014.s009
DOI:
10.3389/fcvm.2022.968014.s010
DOI:
10.3389/fcvm.2022.968014.s011
DOI:
10.3389/fcvm.2022.968014.s012
DOI:
10.3389/fcvm.2022.968014.s013
DOI:
10.3389/fcvm.2022.968014.s014
DOI:
10.3389/fcvm.2022.968014.s015
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2781496-8
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