In:
Advanced Synthesis & Catalysis, Wiley, Vol. 363, No. 4 ( 2021-02-16), p. 1050-1058
Abstract:
Benzofused lactams, especially indolin‐2‐one and dihydroquinolin‐2‐one are popular structural motives in durgs and natural products. Herein, we developed a room temperature and robust synthesis of benzofused lactams through cobalt(III)‐catalyzed C( sp 2 )−H amidation. In this protocol, in‐situ formation of Cp*Co(III)(ligand) catalyst from Cp*Co(CO)I 2 and ligand simplify the synthetic effort of cobalt complexes. Simple and readily synthesized 1,4,2‐dioxazol‐5‐ones underwent room temperature intramolecular C−H amidation and afforded a wide variety of functionalized benzofused lactams in up to 86% yield. The scalability of the reaction is also be demonstrated. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.202001254
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4
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