In:
Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 44, No. 1 ( 2017-01), p. 62-70
Abstract:
The role of second hand smoke ( SHS ) exposure on ulcerative colitis is not known. Our aim was to examine the effects of α‐lipoic acid ( ALA ), chronic aerobic ( AE ) or resistance exercise ( RE ) on SHS exposed rats with colitis. Sprague‐Dawley male rats (150‐200 g, n=54) were selected for colitis induction. Among the colitis groups, one group was exposed to SHS (6 d/wk, 4 cigarettes/d) and the other was not. The SHS group was divided into subgroups as follows: sedentary; AE (swimming; 3 d/wk); and RE (climbing with weight; 3 d/wk). After 5 weeks, colitis was induced by intrarectal acetic acid. All groups had subgroups that were given subcutaneously ALA (50 mg/kg per day) or vehicle for 3 days. Following decapitation, colon tissues were sampled to examine malondialdehyde ( MDA ) and glutathione ( GSH ) levels, myeloperoxidase ( MPO ) activity, luminol and lucigenin chemiluminenscence, macroscopic scoring and histologic examination. ANOVA and Student's t ‐test were used for statistical analysis. The increased macroscopic and microscopic scores, MPO , MDA , luminol and lucigenin measurements in colitis and SHS ‐colitis groups were decreased via ALA ( P 〈 .05‐.001). AE declined macroscopic and microscopic scores, MDA , lucigenin compared to colitis and SHS ‐colitis groups ( P 〈 .01‐.001). RE reduced microscopic score, MPO , MDA , luminol, lucigenin ( P 〈 .05‐.001) that were increased with colitis. Decreased GSH levels ( P 〈 .01) in the SHS ‐colitis group approached to control levels when given ALA . According to our results SHS and colitis induction increased inflammatory damage. SHS did not worsen it more than colitis. Our results suggest that ALA , AE or RE might be protective for SHS exposed ulcerative colitis conditions.
Type of Medium:
Online Resource
ISSN:
0305-1870
,
1440-1681
DOI:
10.1111/cep.2017.44.issue-1
DOI:
10.1111/1440-1681.12682
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2020033-X
SSG:
15,3
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