In:
FEBS Letters, Wiley, Vol. 229, No. 2 ( 1988-03-14), p. 247-250
Abstract:
T‐kininogen is known to be an acute‐phase reactant as well as a kininogen in rat plasma. Three kinds of cytokines, interleukin‐1, tumor necrosis factor and interferon, were assayed for their abilities to stimulate hepatic production of T‐kininogen. Of these cytokines, interferon was able to stimulate hepatic production of T‐kininogen, but few effects were observed for interleukin‐1 and tumor necrosis factor. In addition, the stimulatory effect of interferon was inhibited by tumor necrosis factor. Our data suggest that interferon is a candidate for the leukocyte‐derived factor mediating the acute‐phase response of T‐kininogen.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(88)81134-7
Language:
English
Publisher:
Wiley
Publication Date:
1988
detail.hit.zdb_id:
1460391-3
SSG:
12
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