In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 46, No. 2 ( 2017-08), p. 383-392
Abstract:
To evaluate whether whole‐tumor histogram‐derived parameters for an apparent diffusion coefficient (ADC) map and contrast‐enhanced magnetic resonance imaging (MRI) could aid in assessing Ki‐67 labeling index (LI) of hepatocellular carcinoma (HCC). Materials and Methods In all, 57 patients with HCC who underwent pretreatment MRI with a 3T MR scanner were included retrospectively. Histogram parameters including mean, median, standard deviation, skewness, kurtosis, and percentiles (5 th , 25 th , 75 th , 95 th ) were derived from the ADC map and MR enhancement. Correlations between histogram parameters and Ki‐67 LI were evaluated and differences between low Ki‐67 (≤10%) and high Ki‐67 ( 〉 10%) groups were assessed. Results Mean, median, 5 th , 25 th , 75 th percentiles of ADC, and mean, median, 25 th , 75 th , 95 th percentiles of enhancement of arterial phase (AP) demonstrated significant inverse correlations with Ki‐67 LI (rho up to −0.48 for ADC, −0.43 for AP) and showed significant differences between low and high Ki‐67 groups ( P 〈 0.001–0.04). Areas under the receiver operator characteristics (ROC) curve for identification of high Ki‐67 were 0.78, 0.77, 0.79, 0.82, and 0.76 for mean, median, 5 th , 25 th , 75 th percentiles of ADC, respectively, and 0.74, 0.81, 0.76, 0.82, 0.69 for mean, median, 25 th , 75 th , 95 th percentiles of AP, respectively. Conclusion Histogram‐derived parameters of ADC and AP were potentially helpful for predicting Ki‐67 LI of HCC. Level of Evidence: 3 Technical Efficacy : Stage 3 J. MAGN. RESON. IMAGING 2017;46:383–392
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1497154-9
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