KOBV Portal

Hits per page

hits 1 - 10 | 16 hits

Sorting

Online Resource

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle

Julien, Sofi G. ; Kim, Sun-Yee ; Brunmeir, Reinhard ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS Biology Vol. 15, No. 2 ( 2017-2-16), p. e1002597-

add to watchlist on the watchlist

Details

In: PLOS Biology, Public Library of Science (PLoS), Vol. 15, No. 2 ( 2017-2-16), p. e1002597-

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.1002597

DOI: 10.1371/journal.pbio.1002597.g001

DOI: 10.1371/journal.pbio.1002597.g002

DOI: 10.1371/journal.pbio.1002597.g003

DOI: 10.1371/journal.pbio.1002597.g004

DOI: 10.1371/journal.pbio.1002597.g005

DOI: 10.1371/journal.pbio.1002597.g006

DOI: 10.1371/journal.pbio.1002597.g007

DOI: 10.1371/journal.pbio.1002597.g008

DOI: 10.1371/journal.pbio.1002597.s001

DOI: 10.1371/journal.pbio.1002597.s002

DOI: 10.1371/journal.pbio.1002597.s003

DOI: 10.1371/journal.pbio.1002597.s004

DOI: 10.1371/journal.pbio.1002597.s005

DOI: 10.1371/journal.pbio.1002597.s006

DOI: 10.1371/journal.pbio.1002597.s007

DOI: 10.1371/journal.pbio.1002597.s008

DOI: 10.1371/journal.pbio.1002597.s009

DOI: 10.1371/journal.pbio.1002597.s010

DOI: 10.1371/journal.pbio.1002597.s011

DOI: 10.1371/journal.pbio.1002597.s012

DOI: 10.1371/journal.pbio.1002597.s013

DOI: 10.1371/journal.pbio.1002597.s014

DOI: 10.1371/journal.pbio.1002597.s015

DOI: 10.1371/journal.pbio.1002597.s016

DOI: 10.1371/journal.pbio.1002597.s017

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2126773-X

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection

Yaligar, Jadegoud ; Teoh, Wei Wei. ; Othman, Rashidah ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Scientific Reports Vol. 6, No. 1 ( 2016-02-02)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-02-02)

Abstract: The cumulative effects of hepatic injury due to hepatitis B virus (HBV) infections and aflatoxin-B 1 (AFB 1 ) exposure are the major risk factors of HCC. Understanding early metabolic changes involving these risk factors in an animal model closely resembling human hepatocellular carcinoma (HCC) is critical for biomarker discovery and disease therapeutics. We have used the hepatitis B surface antigen (HBsAg) transgenic mouse model that mimics HBV carriers with and without AFB1 treatment. We investigated early metabolic changes from preneoplastic state to HCC by non-invasive longitudinal imaging in three HCC groups of mice: HBsAg + AFB 1 (Gp-I), AFB 1 alone (Gp-II), HBsAg alone (Gp-III) and a control group (wild-type untreated; Gp-IV). For the first time, we have identified acylcarnitine signals in vivo in the liver prior to the histological manifestation of the tumors in all three groups. Acylcarnitine concentration increased with increase in tumor growth in all HCC mouse models, indicating elevated metabolic activity and increased cell turnover. This was confirmed in a pilot study using human serum from HCC patients, which revealed a higher concentration of acylcarnitine compared with normal subjects. Translational clinical studies can be designed to detect acylcarnitine in patients with high risk factors for HCC.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/srep20299

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Molecular characterization of hepatocarcinogenesis using mouse models

Teoh, Wei Wei ; Xie, Min ; Vijayaraghavan, Aadhitthya ; [et al.]

The Company of Biologists ; 2015

In: Disease Models & Mechanisms ( 2015-01-01)

add to watchlist on the watchlist

Details

In: Disease Models & Mechanisms, The Company of Biologists, ( 2015-01-01)

Abstract: Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed till the late stages, where treatment options become limited. Thus, there is a critical need to identify biomarkers for early detection of the developing HCC, as well as molecular pathways that would be amenable to therapeutic intervention. While analysis of human HCC tissues and serum components may serve these purposes, inability of early detection also precludes possibilities of identification of biomarkers or pathways that are sequentially perturbed at earlier phases of disease progression. We have therefore explored the option of utilizing mouse models to understand in a systematic and longitudinal manner the molecular pathways that are progressively deregulated by various etiological factors in contributing to HCC formation, and report the initial findings in characterizing their validity. Hepatitis B surface antigen transgenic mice was used as a hepatitis model, which have been exposed to aflatoxin-B1 at various stages in life. Our findings confirm a synergistic effect of both these etiological factors, with a gender bias towards males for HCC predisposition. Time-based aflatoxin-B1 treatment also demonstrated the requirement of non-quiescent liver for effective transformation. Tumors from these models with various etiologies resemble human HCCs histologically and at the molecular level. Extensive molecular characterization revealed the presence of a 11-gene HCC-expression signature that was able to discern transformed human hepatocytes from primary cells regardless of etiology, and from other cancer types. Moreover, distinct molecular pathways appear to be deregulated by various etiological agents en route to formation of HCCs, in which common pathways converge, highlighting the existence of etiology-specific as well as common HCC-specific molecular perturbations. This study therefore highlights the utility of these mouse models, which provide a rich resource for the longitudinal analysis of molecular changes and biomarkers associated with HCC that could be exploited further for therapeutic targeting.

Type of Medium: Online Resource

ISSN: 1754-8411 , 1754-8403

URL: Article

DOI: 10.1242/dmm.017624

Language: English

Publisher: The Company of Biologists

Publication Date: 2015

detail.hit.zdb_id: 2451104-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Dynamic contrast‐enhanced MRI of brown and beige adipose tissues

Yaligar, Jadegoud ; Verma, Sanjay Kumar ; Gopalan, Venkatesh ; [et al.]

Wiley ; 2020

In: Magnetic Resonance in Medicine Vol. 84, No. 1 ( 2020-07), p. 384-395

add to watchlist on the watchlist

Details

In: Magnetic Resonance in Medicine, Wiley, Vol. 84, No. 1 ( 2020-07), p. 384-395

Abstract: The vascular blood flow in brown adipose tissue (BAT) is important for handling triglyceride clearance, increased blood flow and oxygenation. We used dynamic contrast‐enhanced (DCE)‐MRI and fat fraction (FF) imaging for investigating vascular perfusion kinetics in brown and beige adipose tissues with cold exposure or treatment with β3‐adrenergic agonist. Methods FF imaging and DCE‐MRI using gadolinium‐diethylenetriaminepentaacetic acid were performed in interscapular BAT (iBAT) and beige tissues using male Wister rats ( n = 38). Imaging was performed at thermoneutral condition and with either cold exposure, treatment with pharmacological agent CL‐316,243, or saline. DCE‐MRI and FF data were co‐registered to enhance the understanding of metabolic activity. Results Uptake of contrast agent in activated iBAT and beige tissues were significantly ( P 〈 .05) higher than nonactivated iBAT. The K trans and k ep increased significantly in iBAT and beige tissues after treatment with either cold exposure or β3‐adrenergic agonist. The FF decreased in activated iBAT and beige tissues. The K trans and FF from iBAT and beige tissues were inversely correlated (r = 0.97; r = 0.94). Significant increase in vascular endothelial growth factor expression and K trans in activated iBAT and beige tissues were in agreement with the increased vasculature and vascular perfusion kinetics. The iBAT and beige tissues were validated by measuring molecular markers. Conclusion Increased K trans and decreased FF in iBAT and beige tissues were in agreement with the vascular perfusion kinetics facilitating the clearance of free fatty acids. The methodology can be extended for the screening of browning agents.

Type of Medium: Online Resource

ISSN: 0740-3194 , 1522-2594

URL: Issue

URL: Article

DOI: 10.1002/mrm.v84.1

DOI: 10.1002/mrm.28118

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 1493786-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Skeletal muscle lipid metabolism studied by advanced magnetic resonance spectroscopy

Pola, Arunima ; Sadananthan, Suresh Anand ; Yaligar, Jadegoud ; [et al.]

Elsevier BV ; 2012

In: Progress in Nuclear Magnetic Resonance Spectroscopy Vol. 65 ( 2012-8), p. 66-76

add to watchlist on the watchlist

Details

In: Progress in Nuclear Magnetic Resonance Spectroscopy, Elsevier BV, Vol. 65 ( 2012-8), p. 66-76

Type of Medium: Online Resource

ISSN: 0079-6565

URL: Article

DOI: 10.1016/j.pnmrs.2012.02.002

RVK:

VG 9500

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1500674-8

SSG: 11

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

Ho, Victor ; Lim, Tong Seng ; Lee, Justin ; [et al.]

Impact Journals, LLC ; 2015

In: Oncotarget Vol. 6, No. 29 ( 2015-09-29), p. 27252-27266

add to watchlist on the watchlist

Details

In: Oncotarget, Impact Journals, LLC, Vol. 6, No. 29 ( 2015-09-29), p. 27252-27266

Type of Medium: Online Resource

ISSN: 1949-2553

URL: Issue

URL: Article

DOI: 10.18632/oncotarget.v6i29

DOI: 10.18632/oncotarget.4583

Language: English

Publisher: Impact Journals, LLC

Publication Date: 2015

detail.hit.zdb_id: 2560162-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats

Gopalan, Venkatesh ; Michael, Navin ; Ishino, Seigo ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Scientific Reports Vol. 6, No. 1 ( 2016-05-20)

add to watchlist on the watchlist

Details

In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-05-20)

Abstract: Both exercise and calorie restriction interventions have been recommended for inducing weight-loss in obese states. However, there is conflicting evidence on their relative benefits for metabolic health and insulin sensitivity. This study seeks to evaluate the differential effects of the two interventions on fat mobilization, fat metabolism, and insulin sensitivity in diet-induced obese animal models. After 4 months of ad libitum high fat diet feeding, 35 male Fischer F344 rats were grouped (n = 7 per cohort) into sedentary control (CON), exercise once a day (EX1), exercise twice a day (EX2), 15% calorie restriction (CR1) and 30% calorie restriction (CR2) cohorts. Interventions were carried out over a 4-week period. We found elevated hepatic and muscle long chain acylcarnitines with both exercise and calorie restriction, and a positive association between hepatic long chain acylcarnitines and insulin sensitivity in the pooled cohort. Our result suggests that long chain acylcarnitines may not indicate incomplete fat oxidation in weight loss interventions. Calorie restriction was found to be more effective than exercise in reducing body weight. Exercise, on the other hand, was more effective in reducing adipose depots and muscle triglycerides, favorably altering muscle/liver desaturase activity and improving insulin sensitivity.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/srep26445

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2615211-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A 12-week aerobic exercise intervention results in improved metabolic function and lower adipose tissue and ectopic fat in high-fat diet fed rats

Gopalan, Venkatesh ; Yaligar, Jadegoud ; Michael, Navin ; [et al.]

Portland Press Ltd. ; 2021

In: Bioscience Reports Vol. 41, No. 1 ( 2021-01-29)

add to watchlist on the watchlist

Details

In: Bioscience Reports, Portland Press Ltd., Vol. 41, No. 1 ( 2021-01-29)

Abstract: Investigations of long-term exercise interventions in humans to reverse obesity is expensive and is hampered by poor compliance and confounders. In the present study, we investigated intrahepatic and muscle fat, visceral and subcutaneous fat pads, plasma metabolic profile and skeletal muscle inflammatory markers in response to 12-week aerobic exercise in an obese rodent model. Six-week-old male Wistar rats (n=20) were randomized to chow-fed control (Control, n=5), sedentary high-fat diet (HFD, n=5), chow-fed exercise (Exercise, n=5) and HFD-fed exercise (HFD+Exercise, n=5) groups. The exercise groups were subjected to 12 weeks of motorized treadmill running at a speed of 18 m/min for 30 min/day. Differences in post-intervention measures were assessed by analysis of covariance (ANCOVA), adjusted for baseline bodyweight and pre-intervention measures, where available. Post-hoc analyses were performed with Bonferroni correction. Plasma metabolic profile was worsened and fat pads, ectopic fat in muscle and liver and inflammatory markers in skeletal muscle were elevated in sedentary HFD-fed animals relative to chow-fed controls. HFD+Exercise animals had significantly lower leptin (P=0.0004), triglycerides (P=0.007), homeostatic model assessment of insulin resistance (HOMA-IR; P=0.065), intramyocellular lipids (IMCLs; P=0.003), intrahepatic lipids (IHLs; P & lt;0.0001), body fat% (P=0.001), subcutaneous adipose tissue (SAT; P & lt;0.0001), visceral adipose (P & lt;0.0001) and total fat mass (P & lt;0.0001), relative to sedentary HFD-fed animals, despite only modestly lower bodyweight. Messenger RNA (mRNA) expression of inflammatory markers Interleukin 6 (IL6) and Tumor necrosis factor α (TNFα) were also reduced with aerobic exercise in skeletal muscle. Our results suggest that 12 weeks of aerobic exercise training is effective in improving metabolic health, fat depots, ectopic fat and inflammation even against a high-fat dietary background.

Type of Medium: Online Resource

ISSN: 0144-8463 , 1573-4935

URL: Article

DOI: 10.1042/BSR20201707

Language: English

Publisher: Portland Press Ltd.

Publication Date: 2021

detail.hit.zdb_id: 2014993-1

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L)

Leow, Melvin Khee-Shing ; Rengaraj, Anantharaj ; Narasimhan, Kothandaraman ; [et al.]

Portland Press Ltd. ; 2022

In: Bioscience Reports Vol. 42, No. 5 ( 2022-05-27)

add to watchlist on the watchlist

Details

In: Bioscience Reports, Portland Press Ltd., Vol. 42, No. 5 ( 2022-05-27)

Abstract: Brown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure. To study BAT function in large human longitudinal cohorts, safe and precise detection methodologies are needed. Although regarded a gold standard, the foray of PET-CT into BAT research and clinical applications is limited by its high ionizing radiation doses. Here, we show that brown adipocytes release exosomes in blood plasma that can be utilized to assess BAT activity. In the present study, we investigated circulating protein biomarkers that can accurately and reliably reflect BAT activation triggered by cold exposure, capsinoids ingestion and thyroid hormone excess in humans. We discovered an exosomal protein, methylene tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L), to be overexpressed and detectable in plasma for all three modes of BAT activation in human subjects. This mitochondrial protein is packaged as a cargo within multivesicular bodies of the endosomal compartment and secreted as exosomes via exocytosis from activated brown adipocytes into the circulation. To support MTHFD1L as a conserved BAT activation response in other vertebrates, we examined a rodent model and also proved its presence in blood of rats following BAT activation by cold exposure. Plasma concentration of exosomal MTHFD1L correlated with human BAT activity as confirmed by PET-MR in humans and supported by data from rats. Thus, we deduce that MTHFD1L appears to be overexpressed in activated BAT compared to BAT in the basal nonstimulated state.

Type of Medium: Online Resource

ISSN: 0144-8463 , 1573-4935

URL: Article

DOI: 10.1042/BSR20212543

Language: English

Publisher: Portland Press Ltd.

Publication Date: 2022

detail.hit.zdb_id: 2014993-1

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Evaluation of Dietary Effects on Hepatic Lipids in High Fat and Placebo Diet Fed Rats by In Vivo MRS and LC-MS Techniques

Yaligar, Jadegoud ; Gopalan, Venkatesh ; Kiat, Ong Wee ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 3 ( 2014-3-17), p. e91436-

add to watchlist on the watchlist

Details

In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 3 ( 2014-3-17), p. e91436-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0091436

DOI: 10.1371/journal.pone.0091436.g001

DOI: 10.1371/journal.pone.0091436.g002

DOI: 10.1371/journal.pone.0091436.g003

DOI: 10.1371/journal.pone.0091436.g004

DOI: 10.1371/journal.pone.0091436.g005

DOI: 10.1371/journal.pone.0091436.g006

DOI: 10.1371/journal.pone.0091436.t001

DOI: 10.1371/journal.pone.0091436.t002

DOI: 10.1371/journal.pone.0091436.s001

DOI: 10.1371/journal.pone.0091436.s002

DOI: 10.1371/journal.pone.0091436.s003

DOI: 10.1371/journal.pone.0091436.s004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 16 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg