In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 22, No. 8 ( 2018-08), p. 4016-4020
Abstract:
The aim of this study was to investigate the association of genetic polymorphisms in the promoter region of miR‐17‐92 with systemic lupus erythematosus ( SLE ). The gene polymorphism was analysed using SN aPshot in 312 SLE patients and 396 controls. Relative expression of miR‐17‐92 was measured by quantitative real‐time PCR . Association was found between rs9515692 and a decreased risk of SLE ( CT vs CC : OR = 0.65, 95% CI , 0.46‐0.92, P = .014; CT + TT vs CC : OR = 0.64, 95% CI , 0.46‐0.90, P = .009; T vs C: OR = 0.69, 95% CI , 0.52‐0.92, P = .010, respectively). Haplotype analysis showed that C‐G‐G, C‐A‐A haplotypes were associated with an increased SLE risk (OR=4.46, 95%CI, 2.17‐9.17, P 〈 0.001; OR=2.33, 95%CI, 1.44‐3.76, P 〈 0.001, respectively). T allele and CT + TT genotypes in rs9515692 were associated with decreased risk of anti‐ds DNA in SLE ( CT + TT vs CC : OR = 0.42, 95% CI = 0.24‐0.72, P = .002; T vs A: OR = 0.49, 95% CI = 0.31‐0.79, P = .003). Moreover, rs9515692 CT + TT genotypes had a higher level of miR‐17 as compared to CC genotype ( P = .017). These findings suggest that the rs9515692 CT + TT genotypes were a protective factor for the susceptibility of SLE , probably by increasing the expression of miR‐17.
Type of Medium:
Online Resource
ISSN:
1582-1838
,
1582-4934
DOI:
10.1111/jcmm.2018.22.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2076114-4
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