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Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Liu, Nana ; Zhang, Longjiang ; Tian, Tian ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Genetics Vol. 55, No. 7 ( 2023-07), p. 1126-1137

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 55, No. 7 ( 2023-07), p. 1126-1137

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/s41588-023-01425-8

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 1494946-5

SSG: 12

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Erratum: Camelid genomes reveal evolution and adaptation to desert environments

Wu, Huiguang ; Guang, Xuanmin ; Al-Fageeh, Mohamed B. ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Nature Communications Vol. 6, No. 1 ( 2015-01-28)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2015-01-28)

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms7107

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 2553671-0

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Camelid genomes reveal evolution and adaptation to desert environments

Wu, Huiguang ; Guang, Xuanmin ; Al-Fageeh, Mohamed B. ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Nature Communications Vol. 5, No. 1 ( 2014-10-21)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2014-10-21)

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms6188

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2553671-0

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Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle

Chen, Songlin ; Zhang, Guojie ; Shao, Changwei ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Nature Genetics Vol. 46, No. 3 ( 2014-3), p. 253-260

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 46, No. 3 ( 2014-3), p. 253-260

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.2890

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 1494946-5

SSG: 12

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Neuromolecular and behavioral effects of cannabidiol on depressive-associated behaviors and neuropathic pain conditions in mice

Shen, Ziyi ; Bao, Nana ; Chen, Junwen ; [et al.]

Elsevier BV ; 2024

In: Neuropharmacology Vol. 261 ( 2024-12), p. 110153-

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In: Neuropharmacology, Elsevier BV, Vol. 261 ( 2024-12), p. 110153-

Type of Medium: Online Resource

ISSN: 0028-3908

URL: Article

DOI: 10.1016/j.neuropharm.2024.110153

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 1500655-4

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Insights into salt tolerance from the genome of Thellungiella salsuginea

Wu, Hua-Jun ; Zhang, Zhonghui ; Wang, Jun-Yi ; [et al.]

Proceedings of the National Academy of Sciences ; 2012

In: Proceedings of the National Academy of Sciences Vol. 109, No. 30 ( 2012-07-24), p. 12219-12224

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 109, No. 30 ( 2012-07-24), p. 12219-12224

Abstract: Thellungiella salsuginea, a close relative of Arabidopsis , represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence of the T. salsuginea genome, assembled based on ∼134-fold coverage to seven chromosomes with a coding capacity of at least 28,457 genes. This genome provides resources and evidence about the nature of defense mechanisms constituting the genetic basis underlying plant abiotic stress tolerance. Comparative genomics and experimental analyses identified genes related to cation transport, abscisic acid signaling, and wax production prominent in T. salsuginea as possible contributors to its success in stressful environments.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.1209954109

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2012

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration

Liu, Yan ; Zhou, Qian ; Wang, Yongjun ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Nature Communications Vol. 6, No. 1 ( 2015-11-24)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2015-11-24)

Abstract: Reptiles are the most morphologically and physiologically diverse tetrapods, and have undergone 300 million years of adaptive evolution. Within the reptilian tetrapods, geckos possess several interesting features, including the ability to regenerate autotomized tails and to climb on smooth surfaces. Here we sequence the genome of Gekko japonicus (Schlegel’s Japanese Gecko) and investigate genetic elements related to its physiology. We obtain a draft G. japonicus genome sequence of 2.55 Gb and annotated 22,487 genes. Comparative genomic analysis reveals specific gene family expansions or reductions that are associated with the formation of adhesive setae, nocturnal vision and tail regeneration, as well as the diversification of olfactory sensation. The obtained genomic data provide robust genetic evidence of adaptive evolution in reptiles.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms10033

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 2553671-0

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The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes

Liu, Shengyi ; Liu, Yumei ; Yang, Xinhua ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Nature Communications Vol. 5, No. 1 ( 2014-05-23)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2014-05-23)

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms4930

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2553671-0

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Table_4.xlsx

Sun, Hao ; Lu, Zhenhua ; Xuan, Guoyun ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Cellular and Infection Microbiology Vol. 11 ( 2021-7-19)

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In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 11 ( 2021-7-19)

Abstract: Hantaan virus (HTNV), the causative pathogen of hemorrhagic fever with renal syndrome (HFRS), is a negative RNA virus belonging to the Orthohantaviridae family. HTNV envelope glycoprotein (GP), encoded by the genomic medium segment, is immunogenic and is therefore a promising vaccine candidate. Major histocompatibility complex class I (MHC-I) epitopes derived from HTNV has been extensively studied, but little is known of MHC-II epitopes. In silico predictions based on four databases indicated that the full-length HTNV GP has 1121 15-mer epitopes, of which 289 had a high score for binding to the human and murine MHC-II superfamily. It found that epitope ILTVLKFIANIFHTS could potentially bind most MHC-II molecules covering human and murine haplotypes. Dominant epitopes were validated by enzyme-linked immunospot assay of splenocytes from immunized mice; 6 of 10 epitopes supported the predictions including TATYSIVGPANAKVP, TKTLVIGQCIYTITS, FSLLPGVAHSIAVEL, CETYKELKAHGVSCP, CGLYLDRLKPVGSAY, and NLGENPCKIGLQTSS. Conservation analysis of dominant epitopes revealed host–virus interactions without geographic stratification, thus meeting the requirements of candidate vaccines for large-population prophylaxis. These findings provide insight into hantavirus antigenicity and suggest that vaccines targeting MHC-II could provide immune protection in large population to complement symptomatic therapies for the treatment of HFRS.

Type of Medium: Online Resource

ISSN: 2235-2988

URL: Article

DOI: 10.3389/fcimb.2021.671694

DOI: 10.3389/fcimb.2021.671694.s001

DOI: 10.3389/fcimb.2021.671694.s002

DOI: 10.3389/fcimb.2021.671694.s003

DOI: 10.3389/fcimb.2021.671694.s004

DOI: 10.3389/fcimb.2021.671694.s005

DOI: 10.3389/fcimb.2021.671694.s006

DOI: 10.3389/fcimb.2021.671694.s007

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2619676-1

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Microbial and metabolic features in renal transplant recipients with post‐transplantation diabetes mellitus

He, Jiayang ; Yang, Mengchang ; Quan, Xiangming ; [et al.]

Wiley ; 2023

In: International Journal of Urology Vol. 30, No. 6 ( 2023-06), p. 504-513

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In: International Journal of Urology, Wiley, Vol. 30, No. 6 ( 2023-06), p. 504-513

Abstract: Post‐transplantation diabetes mellitus (PTDM) is a common complication in renal transplant recipients (RTRs). Gut microbiome plays important roles in a variety of chronic metabolic diseases, but its association with the occurrence and development of PTDM is still unknown. The present study integrates the analysis of gut microbiome and metabolites to further identify the characteristics of PTDM. Methods A total of 100 RTRs fecal samples were collected in our study. Among them, 55 samples were submitted to Hiseq sequencing, and 100 samples were used for non‐targeted metabolomics analysis. The gut microbiome and metabolomics of RTRs were comprehensively characterized. Results The species Dialister invisus was significantly associated with fasting plasma glucose (FPG). The functions of tryptophan and phenylalanine biosynthesis were enhanced in RTRs with PTDM, while the functions of fructose and butyric acid metabolism were reduced. Fecal metabolome analysis indicated that RTRs with PTDM had unique metabolite distribution characteristics, and two differentially expressed specific metabolites were significantly correlated with FPG. The correlation analysis of gut microbiome and metabolites showed that gut microbiome had an obvious effect on the metabolic characteristics of RTRs with PTDM. Moreover, the relative abundance of microbial function is associated with the expression of several specific gut microbiome and metabolites. Conclusions Our study identified the characteristics of gut microbiome and fecal metabolites in RTRs with PTDM, and we also found two important metabolites and a bacterium were significantly associated with PTDM, which might be used as novel targets in the research field of PTDM.

Type of Medium: Online Resource

ISSN: 0919-8172 , 1442-2042

URL: Issue

URL: Article

DOI: 10.1111/iju.v30.6

DOI: 10.1111/iju.15158

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2009793-1

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