In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 70, No. suppl_1 ( 2017-09)
Abstract:
Background: Recently, patients with both sarcopenia and abdominal obesity are known to exhibit subclinical atherosclerosis and high mortality risk. Sarcopenic obesity is considered to be latent in those without increase in body mass index (BMI) despite having abdominal obesity. We aimed to investigate whether arterial stiffening and severity of orthostatic hypotension, which is the risk of cardiovascular disease, is associated with lower BMI in patients with abdominal obesity. Methods: We studied middle-aged and older patients with normal to high BMI (BMI ≥ 18.5) and being treated with life-style related diseases. The patients were divided into 2 groups (with or without abdominal obesity) according to waist circumference (WC) (abdominal obesity: men; WC ≥ 85 cm, women; WC ≥ 90 cm). We measured cardio-vascular ankle index (CAVI) for an index of arterial stiffness. We assessed sit-to-stand test for measuring orthostatic systolic blood pressure (SBP) change. Results: One thousand and forty-six patients were included in the study. Mean age of the patients was 68.0 ± 10.1 years (42.5% were men), hypertension dyslipidemia and diabetes mellitus was observed in 83.3%, 74.3% and 20.2% of the patients respectively. There was a significant negative correlation with BMI and CAVI in patients with abdominal obesity (r=-0.309, p 〈 0.001, n=434), whereas no significant association was observed in patients without abdominal obesity (p=N.S., n=612). There was a significant positive correlation with BMI and orthostatic SBP change in patients with abdominal obesity (r=0.213, p 〈 0.001) and in patients without abdominal obesity (r=0.117, P=0.004). Multivariate regression analysis revealed that BMI was an independent determinant of CAVI and orthostatic SBP change in patients with abdominal obesity (p 〈 0.001, p 〈 0.001, respectively), and was an independent determinant of orthostatic SBP change in patients without abdominal obesity (p=0.004). Conclusion: In patients with abdominal obesity, lower BMI was an independent determinant of arterial stiffening and severity of orthostatic hypotension. Further investigation by evaluating body composition is necessary and now ongoing to assess the risk of lower BMI in patients with abdominal obesity.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/hyp.70.suppl_1.p492
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2017
detail.hit.zdb_id:
2094210-2
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