In:
Biomaterials Science, Royal Society of Chemistry (RSC), Vol. 11, No. 16 ( 2023), p. 5540-5548
Abstract:
Rhenium disulfide (ReS 2 ) with distinct physicochemical properties has shown promising potential in disease theranostics, such as drug delivery, computed tomography (CT), radiotherapy, and photothermal therapy (PTT). However, the synthesis and post-modification of ReS 2 agents for different application scenarios are time- and energy-consuming, which seriously hinders the clinical translation of ReS 2 . Herein, we proposed three facile excipient strategies for different theranostic applications of ReS 2 just through the flexible use of commercial ReS 2 powder. Three excipients, including sodium alginate (ALG), xanthan gum (XG), and ultraviolet-cured resin (UCR), were used to prepare different dosage forms of commercial ReS 2 powder, like hydrogel, suspension, and capsule, respectively. These dosage forms of ReS 2 with distinct characteristics showed great potential for second near-infrared window PTT against tumours, gastric spectral CT imaging, and functional evaluation of the digestive tract in vivo . In addition, these ReS 2 formulations exhibited good biocompatibility both in vitro and in vivo , showing a promising prospect for clinical transformation. More importantly, the facile excipient strategies for commercial agents pave a bridge to the development and wide bioapplication of many other theranostic biomaterials.
Type of Medium:
Online Resource
ISSN:
2047-4830
,
2047-4849
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
2693928-9
Bookmarklink
