In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 4 ( 2023-4-21), p. e0284494-
Abstract:
To investigate the association between insomnia and the risk of various cancers using the Korean National Health Insurance Service database. Materials and methods Patients who underwent a national health examination in 2009 were followed-up until 2018. Newly-diagnosed cancers were collected one year after the baseline. Insomnia was defined as having a diagnosis of F510 or G470 within one year prior to enrollment. The incidence of various cancers was compared between patients with and without insomnia. Results In the overall study population (N = 3,982,012), the risk for any type of cancer was not different between controls and insomnia patients (adjusted hazard ratio [aHR]: 0.990). However, it was different by age; insomnia increased the risk of any cancer in younger age groups (20–39y and 40–59y, aHR:1.310 and 1.139, respectively) but it significantly decreased the risk in the 60–79y age group (aHR: 0.939). In cancer type, colorectal cancer risk was lower (aHR: 0.872, P 〈 0.0001), whereas leukemia risk was higher (aHR: 1.402, P 〈 0.0001) in patients with insomnia than in those without it, regardless of sex. In men, the risk of stomach cancer was lower (aHR: 0.882, P = 0.0003), and the risks of lung (aHR:1.114, P = 0.0005), kidney (aHR 1.226, P = 0.0107), and prostate (aHR:1.101, P = 0.0028) cancers were higher in insomnia patients than in control patients. In women, insomnia patients compared to control patients showed a lower risk of ovarian cancer (aHR:0.856, P = 0.0344, respectively), while they had a higher risk of oral (aHR:1.616, P = 0.002), thyroid (aHR:1.072, P = 0.0192), and nerve (aHR: 1.251, P = 0.016) cancers. Conclusion Insomnia is associated with an increased or decreased risk of some cancers, depending on age, cancer type and sex.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0284494
DOI:
10.1371/journal.pone.0284494.g001
DOI:
10.1371/journal.pone.0284494.g002
DOI:
10.1371/journal.pone.0284494.t001
DOI:
10.1371/journal.pone.0284494.t002
DOI:
10.1371/journal.pone.0284494.t003
DOI:
10.1371/journal.pone.0284494.s001
DOI:
10.1371/journal.pone.0284494.s002
DOI:
10.1371/journal.pone.0284494.s003
DOI:
10.1371/journal.pone.0284494.s004
DOI:
10.1371/journal.pone.0284494.s005
DOI:
10.1371/journal.pone.0284494.s006
DOI:
10.1371/journal.pone.0284494.s007
DOI:
10.1371/journal.pone.0284494.r001
DOI:
10.1371/journal.pone.0284494.r002
DOI:
10.1371/journal.pone.0284494.r003
DOI:
10.1371/journal.pone.0284494.r004
DOI:
10.1371/journal.pone.0284494.r005
DOI:
10.1371/journal.pone.0284494.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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