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Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Wang, Xin ; Li, You ; O'Brien, Katherine L ; [et al.]

Elsevier BV ; 2020

In: The Lancet Global Health Vol. 8, No. 4 ( 2020-04), p. e497-e510

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In: The Lancet Global Health, Elsevier BV, Vol. 8, No. 4 ( 2020-04), p. e497-e510

Type of Medium: Online Resource

ISSN: 2214-109X

URL: Article

DOI: 10.1016/S2214-109X(19)30545-5

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2723488-5

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Molecular evolution of human respiratory syncytial virus attachment glycoprotein (G) gene of new genotype ON1 and ancestor NA1

Hirano, Eiko ; Kobayashi, Miho ; Tsukagoshi, Hiroyuki ; [et al.]

Elsevier BV ; 2014

In: Infection, Genetics and Evolution Vol. 28 ( 2014-12), p. 183-191

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In: Infection, Genetics and Evolution, Elsevier BV, Vol. 28 ( 2014-12), p. 183-191

Type of Medium: Online Resource

ISSN: 1567-1348

URL: Article

DOI: 10.1016/j.meegid.2014.09.030

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 2057622-5

SSG: 12

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Mortality Associated With Pulmonary Hypertension in Congenital Rubella Syndrome

Toizumi, Michiko ; Motomura, Hideki ; Vo, Hien Minh ; [et al.]

American Academy of Pediatrics (AAP) ; 2014

In: Pediatrics Vol. 134, No. 2 ( 2014-08-01), p. e519-e526

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In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 134, No. 2 ( 2014-08-01), p. e519-e526

Abstract: Outbreaks of rubella and congenital rubella syndrome (CRS) continue to arise in various countries where a rubella-containing vaccine is not included in the national immunization program. After a large-scale rubella outbreak in 2011, CRS cases emerged in Vietnam. The aim of this study was to clarify the clinical features of these cases with an emphasis on cardiovascular complications and outcomes. METHODS: From October 2011 to September 2012, we conducted a prospective surveillance study of infants & lt;12 months of age who had manifestations suggesting CRS at the only referral hospital in Khanh Hoa Province. These infants underwent standard examinations, echocardiography, cranial ultrasonography, automated auditory brainstem responses, blood cell count measurements, and rubella-specific antibody testing. Detected cardiovascular defects were regularly followed with echocardiography. RESULTS: We enrolled 38 cases of CRS characterized by a low birth weight (71%), cardiovascular defects (72%), cataracts (13%), hearing impairment (93%), purpura (84%), hepatosplenomegaly (68%), and thrombocytopenia (76%). Patent ductus arteriosus, the most common cardiovascular complication, was often associated with progressive pulmonary hypertension (PH). As of January 2013, 13 infants (34%) had died, and PH was significantly more frequent among the fatalities (P = .004); however, therapeutic closure of the ductus reversed the PH in several cases. CONCLUSIONS: PH-associated mortality is high among infants who have CRS in Vietnam. Providing proper assessments, continuous follow-up, and timely intervention for cardiovascular defects is critical for the management of CRS patients. Echocardiography is of diagnostic and prognostic value and can support better clinical management of CRS, even in a developing country setting.

Type of Medium: Online Resource

ISSN: 0031-4005 , 1098-4275

URL: Article

DOI: 10.1542/peds.2013-4184

Language: English

Publisher: American Academy of Pediatrics (AAP)

Publication Date: 2014

detail.hit.zdb_id: 1477004-0

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Evolutionary dynamics of influenza B strains detected from paediatric acute respiratory infections in central Vietnam

Yoshihara, Keisuke ; Minh, Le Nhat ; Okada, Takashi ; [et al.]

Elsevier BV ; 2020

In: Infection, Genetics and Evolution Vol. 81 ( 2020-07), p. 104264-

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In: Infection, Genetics and Evolution, Elsevier BV, Vol. 81 ( 2020-07), p. 104264-

Type of Medium: Online Resource

ISSN: 1567-1348

URL: Article

DOI: 10.1016/j.meegid.2020.104264

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2057622-5

SSG: 12

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Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Li, You ; Wang, Xin ; Blau, Dianna M ; [et al.]

Elsevier BV ; 2022

In: The Lancet Vol. 399, No. 10340 ( 2022-05), p. 2047-2064

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In: The Lancet, Elsevier BV, Vol. 399, No. 10340 ( 2022-05), p. 2047-2064

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(22)00478-0

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

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Association of pneumococcal carriage in infants with the risk of carriage among their contacts in Nha Trang, Vietnam: A nested cross-sectional survey

Qian, George ; Toizumi, Michiko ; Clifford, Sam ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Medicine Vol. 19, No. 5 ( 2022-5-31), p. e1004016-

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In: PLOS Medicine, Public Library of Science (PLoS), Vol. 19, No. 5 ( 2022-5-31), p. e1004016-

Abstract: Infants are at highest risk of pneumococcal disease. Their added protection through herd effects is a key part in the considerations on optimal pneumococcal vaccination strategies. Yet, little is currently known about the main transmission pathways to this vulnerable age group. Hence, this study investigates pneumococcal transmission routes to infants in the coastal city of Nha Trang, Vietnam. Methods and findings In October 2018, we conducted a nested cross-sectional contact and pneumococcal carriage survey in randomly selected 4- to 11-month-old infants across all 27 communes of Nha Trang. Bayesian logistic regression models were used to estimate age specific carriage prevalence in the population, a proxy for the probability that a contact of a given age could lead to pneumococcal exposure for the infant. We used another Bayesian logistic regression model to estimate the correlation between infant carriage and the probability that at least one of their reported contacts carried pneumococci, controlling for age and locality. In total, 1,583 infants between 4 and 13 months old participated, with 7,428 contacts reported. Few infants (5%, or 86 infants) attended day care, and carriage prevalence was 22% (353 infants). Most infants (61%, or 966 infants) had less than a 25% probability to have had close contact with a pneumococcal carrier on the surveyed day. Pneumococcal infection risk and contact behaviour were highly correlated: If adjusted for age and locality, the odds of an infant’s carriage increased by 22% (95% confidence interval (CI): 15 to 29) per 10 percentage points increase in the probability to have had close contact with at least 1 pneumococcal carrier. Moreover, 2- to 6-year-old children contributed 51% (95% CI: 39 to 63) to the total direct pneumococcal exposure risks to infants in this setting. The main limitation of this study is that exposure risk was assessed indirectly by the age-dependent propensity for carriage of a contact and not by assessing carriage of such contacts directly. Conclusions In this study, we observed that cross-sectional contact and infection studies could help identify pneumococcal transmission routes and that preschool-age children may be the largest reservoir for pneumococcal transmission to infants in Nha Trang, Vietnam.

Type of Medium: Online Resource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/journal.pmed.1004016

DOI: 10.1371/journal.pmed.1004016.g001

DOI: 10.1371/journal.pmed.1004016.g002

DOI: 10.1371/journal.pmed.1004016.g003

DOI: 10.1371/journal.pmed.1004016.t001

DOI: 10.1371/journal.pmed.1004016.t002

DOI: 10.1371/journal.pmed.1004016.s001

DOI: 10.1371/journal.pmed.1004016.s002

DOI: 10.1371/journal.pmed.1004016.s003

DOI: 10.1371/journal.pmed.1004016.s004

DOI: 10.1371/journal.pmed.1004016.s005

DOI: 10.1371/journal.pmed.1004016.s006

DOI: 10.1371/journal.pmed.1004016.s007

DOI: 10.1371/journal.pmed.1004016.r001

DOI: 10.1371/journal.pmed.1004016.r002

DOI: 10.1371/journal.pmed.1004016.r003

DOI: 10.1371/journal.pmed.1004016.r004

DOI: 10.1371/journal.pmed.1004016.r005

DOI: 10.1371/journal.pmed.1004016.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2164823-2

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Nasopharyngeal Bacterial Interactions in Children

Suzuki, Motoi ; Dhoubhadel, Bhim Gopal ; Yoshida, Lay Myint ; [et al.]

Centers for Disease Control and Prevention (CDC) ; 2014

In: Emerging Infectious Diseases Vol. 20, No. 2 ( 2014-02), p. 323-324

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In: Emerging Infectious Diseases, Centers for Disease Control and Prevention (CDC), Vol. 20, No. 2 ( 2014-02), p. 323-324

Type of Medium: Online Resource

ISSN: 1080-6040 , 1080-6059

URL: Article

DOI: 10.3201/eid2002.121724

Language: English

Publisher: Centers for Disease Control and Prevention (CDC)

Publication Date: 2014

detail.hit.zdb_id: 2004375-2

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Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam

Miyakawa, Masami ; Yoshida, Lay-Myint ; Nguyen, Hien-Anh Thi ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Scientific Reports Vol. 11, No. 1 ( 2021-04-21)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-04-21)

Abstract: A birth cohort study was conducted in Khan Hoa Province, central Vietnam between 2009 and 2012 to determine the seroprevalence of hepatitis B virus (HBV) in pregnant women and their children, and associated risk factors. We enrolled 1987 pregnant women with their babies at the birth phase, and 12.6% (95% confidence interval [CI]: 11.1–14.0) of mothers were hepatitis B surface antigen (HBsAg)+. At 2-year follow-up phase, 1339 (67.4%) children were enrolled of whom 76.6% completed hepatitis B vaccines (HepB) and 1.9% (95% CI: 1.2–2.7) were HBsAg+. When mothers were hepatitis B e antigen (HBeAg)+, 28.3% of children have got infected even with complete HepB. HBV infection in mothers, hepatitis B surface antibody (anti-HBs antibody) below the seroprotective level in children, and mothers with pre-pregnancy low body mass index were associated with HBV infection in children. Meanwhile, HBV infection in children, older maternal age, no or incomplete doses of HepB, and boys were associated with anti-HBs antibody below the seroprotective level in children. Our birth cohort study determined a low rate of congenital HBV infection and associated risk factors in Vietnam, however further studies are needed to advance prevention including anti-viral therapy in pregnant women at high risk.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-021-87860-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2615211-3

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Characteristics of Patent Ductus Arteriosus in Congenital Rubella Syndrome

Toizumi, Michiko ; Do, Cam Giang T. ; Motomura, Hideki ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Scientific Reports Vol. 9, No. 1 ( 2019-11-19)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-11-19)

Abstract: This study investigated the characteristics of congenital rubella syndrome (CRS)-associated cardiac complications, particularly patent ductus arteriosus (PDA). We reviewed the medical records of patients with CRS who were admitted to the Children’s Hospital 1 in Vietnam between December 2010 and December 2012, and patients with CRS who underwent PDA transcatheter occlusion therapy at the cardiology department between December 2009 and December 2015. We compared the characteristics of PDA treated with transcatheter closure between children with CRS (CRS-PDA) and those without CRS (non-CRS-PDA) who underwent PDA transcatheter closure between July 2014 and December 2015. One-hundred-and-eight children with CRS were enrolled. Cardiac defects (99%), cataracts (72%), and hearing impairment (7%) were detected. Fifty CRS-PDA and 290 non-CRS-PDA patients were examined. CRS-PDA patients had smaller median birthweight (p 〈 0.001), more frequent pulmonary (p 〈 0.001) and aortic stenosis (p 〈 0.001), higher main pulmonary artery pressure, and higher aortic pressure in systole/diastole (p 〈 0.001 for each) than did non-CRS-PDA patients. The proportion of tubular-type PDA was higher in CRS-PDA patients (16%) than in non-CRS-PDA patients (3%) (p = 0.020). Tubular-type PDA was frequently seen in patients with CRS and accompanied by pulmonary/systemic hypertension and pulmonary/aortic stenosis; in these patients, more cautious device selection is needed for transcatheter PDA closure.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-019-52936-6

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2615211-3

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Exposure to paternal tobacco smoking increased child hospitalization for lower respiratory infections but not for other diseases in Vietnam

Miyahara, Reiko ; Takahashi, Kensuke ; Anh, Nguyen Thi Hien ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Scientific Reports Vol. 7, No. 1 ( 2017-03-31)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-03-31)

Abstract: Exposure to environmental tobacco smoke (ETS) is an important modifiable risk factor for child hospitalization, although its contribution is not well documented in countries where ETS due to maternal tobacco smoking is negligible. We conducted a birth cohort study of 1999 neonates between May 2009 and May 2010 in Nha Trang, Vietnam, to evaluate paternal tobacco smoking as a risk factor for infectious and non-infectious diseases. Hospitalizations during a 24-month observation period were identified using hospital records. The effect of paternal exposure during pregnancy and infancy on infectious disease incidence was evaluated using Poisson regression models. In total, 35.6% of 1624 children who attended follow-up visits required at least one hospitalization by 2 years of age, and the most common reason for hospitalization was lower respiratory tract infection (LRTI). Paternal tobacco smoking independently increased the risk of LRTI 1.76-fold (95% CI: 1.24–2.51) after adjusting for possible confounders but was not associated with any other cause of hospitalization. The population attributable fraction indicated that effective interventions to prevent paternal smoking in the presence of children would reduce LRTI-related hospitalizations by 14.8% in this epidemiological setting.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/srep45481

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2615211-3

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