In:
Cancer Medicine, Wiley, Vol. 5, No. 11 ( 2016-11), p. 3236-3335
Abstract:
Although several studies reported genetic polymorphisms in protein kinase AMP ‐activated alpha 1 catalytic subunit ( PRKAA 1 ) and their associations with gastric cancer risk, few have evaluated associations between Helicobacter pylori infection and PRKAA 1 gene‐environment interactions. Here, we evaluated the effects of interactions between H. pylori infection and PRKAA 1 polymorphisms on gastric cancer risk in Koreans. In this hospital‐based case–control study, PRKAA 1 genotypes were analyzed and H. pylori infection and CagA status were examined using a serologic method in 846 pairs of gastric cancer patients and controls matched for age and sex. H. pylori seropositivity was associated with a 1.43‐fold [95% confidence interval: 1.12–1.81] increase in the risk of gastric cancer, and CagA low‐positive titers during H. pylori infection increased the risk by 1.85‐fold (95% confidence interval, 1.38–2.48). Significant positive interaction between the PRKAA 1 rs13361707 genotype and H. pylori infection was verified on an additive scale [relative excess risk due to interaction, 0.55; 95% confidence interval, 0.05–1.04; P = 0.030], and the gene‐environment interaction between PRKAA 1 rs13361707 and CagA status was also statistically significant (relative excess risk due to interaction, 0.50; 95% confidence interval, 0.30–0.70; P 〈 0.001). Our results indicated that H. pylori infection, CagA status, and PRKAA 1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2016.5.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2659751-2
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