In:
The Journal of Immunology, The American Association of Immunologists, Vol. 188, No. 1_Supplement ( 2012-05-01), p. 172.20-172.20
Abstract:
An alternative adaptive immune system is present in the most basal vertebrates, lampreys and hagfish, the only surviving jawless vertebrates. These eel-like fish use leucine-rich-repeat (LRR)-based receptors, called variable lymphocyte receptors (VLRs), for antigen recognition instead of the immunoglobulin (Ig)-based receptors used in jawed vertebrates. We showed that in Japanese lamprey (Lampetra japonica), antigen-specific VLRB antibodies interact with C1q-like and C3 proteins to mediate complement-dependent cytotoxicity for bacteria and tumor cells. The immune based lysis involved deposition of VLRB and C1q-like protein complex on the surface of target cells, activation of C3, and ultimate disruption of cell wall integrity. The demonstration of functional interaction between VLRB and complement components in lamprey provides evidence for the emergence of cooperative innate and adaptive immune responses at a pivotal point in vertebrate evolution, before or in parallel with the evolution of Ig-based antibodies and the classical complement activation pathway.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.188.Supp.172.20
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2012
detail.hit.zdb_id:
1475085-5
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