In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 36, No. 6_suppl ( 2018-02-20), p. 612-612
Abstract:
612 Background: Preservation of parenchymal mass and ischemia type/duration can influence functional recovery after partial nephrectomy (PN). Some have hypothesized that relevant comorbidities may also impact functional recovery, but this has not been adequately investigated. Methods: 405 patients with PN at our center (2007-2015) had necessary data to determine function/parenchymal mass preserved within the ipsilateral kidney. All comorbidities potentially associated with renal functional status were reviewed. Multivariable linear regression assessed factors associated with functional recovery, defined as percent ipsilateral GFR preserved. Results: Median tumor size and R.E.N.A.L. score were 3.5cm and 8, respectively. Overall, 264 (65%) patients had warm ischemia and 141cold ischemia (median durations = 21/27 minutes, respectively). The median ipsilateral GFR preserved was 79%. Age, comorbidity index, hypertension, and proteinuria all associated with preoperative GFR (all p 〈 0.01). Parenchymal mass preserved and ischemia characteristics significantly associated with functional recovery (all p 〈 0.001). On univariable analysis of comorbidities, only hypertension associated significantly with functional recovery. However, on multivariate analysis, none of the analyzed comorbidities associated with functional recovery. Conclusions: Recovery of function after PN depends primarily on parenchymal mass preservation and ischemia characteristics, while comorbidities failed to associate with functional outcomes. Comorbidities can impact function leading into surgery and may influence long-term functional stability, yet our data suggest that they do not influence short-term recovery after PN. [Table: see text]
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/JCO.2018.36.6_suppl.612
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2018
detail.hit.zdb_id:
2005181-5
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