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  • 1
    Online Resource
    Online Resource
    Associação de variáveis sociodemográficas e clínicas com o estadiamento inicial em homens com câncer de próstata
    FapUNIFESP (SciELO) ; 2014
    In:  Cadernos Saúde Coletiva Vol. 22, No. 1 ( 2014-03), p. 93-100
    Details
    In: Cadernos Saúde Coletiva, FapUNIFESP (SciELO), Vol. 22, No. 1 ( 2014-03), p. 93-100
    Abstract: Prostate cancer has become a Public Health problem, being the malignant neoplasm with the highest incidence rate in Brazilian men. Will be estimated, for the years of 2014 and 2015, 302,350 cases of cancer in males, of which 68,800 (22.8%) are from prostate cancer. The State of Espírito Santo is among the 7 Brazilian States with the highest incidence, with an estimated 1,580 cases of prostate cancer per year, reflecting an incidence rate of 88.72/100,000 inhabitants. In the State capital, Vitória, it is assumed that this rate is 107.21/100,000 inhabitants, representing 170 cases1. The objective of this study was to evaluate the association of sociodemographic and clinical factors with the initial staging in men with prostate cancer. An observational cross-sectional secondary data research, assessing 1,500 records of men with prostate cancer from 2000 to 2006 seen at a referral center for the treatment of prostate cancer in Vitória, Espírito Santo. For statistical treatment of the data were used χ2 test of association and logistic regression with Odds Ratios(OR). There was a predominance of men aged between 60 and 79 years (75%), non-white (61%), with incomplete primary education (65%), married (77%), using the Unified Health System (UHS) (60%), residing in the State Metropolitan Area (67%) and with clinical stage II (70%). The variables non-white (p=0.025), Gleason score ≥7 (p≤0.001) and prostate-specific antigen (PSA) 〉 20 ng/dL (p≤0.001) were associated with late stage at diagnosis, while the undiagnosed referral without previous treatment (p≤0.001) or with diagnosis and treatment (p=0.018) were associated with a greater chance of early clinical staging. The variables that accounted for the increased risk of late stage at diagnosis can be modified by the adoption of specific public policies. With the advancement of the National Comprehensive Health Care of Men (NCHCM), it is expected that a larger number of men have access to the health care network, obtaining early diagnosis and timely treatment.
    Type of Medium: Online Resource
    ISSN: 2358-291X , 1414-462X
    URL: Article
    DOI: 10.1590/1414-462X201400010014
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2014
    detail.hit.zdb_id: 2617097-8
    SSG: 7,36
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  • 2
    Online Resource
    Online Resource
    Mortality Among Men Bearing Prostate Cancer and its Association With Sociodemographic and Clinical Variables / Mortalidade em Homens com Câncer de Próstata e sua Associação com Variáveis Sociodemográficas e Clínicas
    Universidade Federal do Estado do Rio de Janeiro UNIRIO ; 2020
    In:  Revista de Pesquisa Cuidado é Fundamental Online Vol. 11, No. 3 ( 2020-02-14), p. 648-654
    Details
    In: Revista de Pesquisa Cuidado é Fundamental Online, Universidade Federal do Estado do Rio de Janeiro UNIRIO, Vol. 11, No. 3 ( 2020-02-14), p. 648-654
    Abstract: Objetivo: Avaliar a associação de variáveis sociodemográficas e clínicas com a mortalidade geral e específica por câncer de próstata. Método: Estudo retrospectivo de 1290 homens diagnosticados com câncer de próstata entre 2000 e 2006. Consultou-se prontuários, Sistema de Registro Hospitalar e Sistema de Informações sobre Mortalidade. Resultados: Dos 1290 homens, 758 estavam vivos, 308 morreram por câncer de próstata e 224 por outras causas. Associaram-se ao óbito por câncer de próstata: escore de Gleason 〉 9, PSA 〉 20 (entre 2,82 e 5,55 vezes) e presença de metástase. Associaram-se ao óbito por outras causas: estado civil viúvo, ingresso no hospital sem diagnóstico e sem tratamento e PSA 〉 50. Conclusão: Variáveis clínicas predominaram sobre a mortalidade específica por câncer de próstata, já variáveis sociodemográficas em óbitos por outras causas.Descritores: Neoplasias da próstata, Mortalidade, Saúde do homem, Políticas públicas.
    Type of Medium: Online Resource
    ISSN: 2175-5361 , 1809-6107
    URL: Article
    DOI: 10.9789/2175-5361.2019.v11i3.648-654
    Language: Unknown
    Publisher: Universidade Federal do Estado do Rio de Janeiro UNIRIO
    Publication Date: 2020
    detail.hit.zdb_id: 2577547-9
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  • 3
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    Online Resource
    An exploratory pilot study on the involvement of APOE, HFE, C9ORF72 variants and comorbidities in neurocognitive and physical performance in a group of HIV-infected people
    Springer Science and Business Media LLC ; 2022
    In:  Metabolic Brain Disease Vol. 37, No. 5 ( 2022-06), p. 1569-1583
    Details
    In: Metabolic Brain Disease, Springer Science and Business Media LLC, Vol. 37, No. 5 ( 2022-06), p. 1569-1583
    Abstract: Cognitive decline of aging is modulated by chronic inflammation and comorbidities. In people with HIV-infection (PWH) it may also be affected by HIV-induced inflammation, lifestyle and long-term effects of antiretroviral therapies (ART). The role of genetics in the susceptibility to HIV-associated neurocognitive disorders (HAND) is not fully understood. Here we explored the possible relations among variants in 3 genes involved in inflammation and neurodegenerative disorders (APOE: ε2/ε3/ε4; HFE: H63D; C9ORF72: hexanucleotide expansions ≥ 9 repeats), cognitive/functional impairment (MiniMental State Examination MMSE, Clock Drawing Test CDT, Short Physical Performance Battery SPPB), comorbidities and HIV-related variables in a cohort of  〉  50 years old PWH (n = 60) with at least 10 years efficient ART. Patients with diabetes or hypertension showed significantly lower MMSE (p = .031) or SPPB (p = .010) scores, respectively, while no relations between HIV-related variables and cognitive/functional scores were observed. Patients with at least one APOEε3 allele had higher CDT scores (p = .019), APOEε2/ε4 patients showing the lowest scores in all tests. Patients with HFE-H63D variant showed more frequently hypertriglyceridemia (p = .023) and those harboring C9ORF72 expansions  〉  9 repeats had higher CD4 + -cell counts (p = .032) and CD4% (p = .041). Multiple linear regression analysis computed to verify possible associations among cognitive/functional scores and all variables further suggested positive association between higher CDT scores and the presence of at least one APOEε3 allele (2,2; 95% CI [0,03 0,8]; p = .037), independent of other variables, although the model did not reach the statistical significance (p = .14). These data suggest that in PWH on efficient ART cognitive abilities and physical performances may be partly associated with comorbidities and genetic background. However, further analyses are needed to establish whether they could be also dependent and influenced by comorbidities and genetic background.
    Type of Medium: Online Resource
    ISSN: 0885-7490 , 1573-7365
    URL: Article
    DOI: 10.1007/s11011-022-00975-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2018067-6
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  • 4
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    Online Resource
    How’s going on the T-Cell Brazil project
    MedCrave Group Kft. ; 2021
    In:  Hematology & Transfusion International Journal Vol. 9, No. 3 ( 2021-5-21), p. 53-55
    Details
    In: Hematology & Transfusion International Journal, MedCrave Group Kft., Vol. 9, No. 3 ( 2021-5-21), p. 53-55
    Abstract: Lymphomas are a large, heterogeneous and infrequent group of neoplasms. Peripheral t-cell lymphomas (PTCL) is still rarer, and it makes up about 10-15% of lymphoid malignancies. Its prognosis is poor and remains a challenge. In April 2017, the first Brazilian collaborative effort was created to collect data from T-cell Lymphoma patients diagnosed in the five distinct macro-regions of Brazil. To better understand PTCL, according to the revised WHO-2017 classification, excluding Mycosis fungoides, Sézary syndrome, and chronic Lymphoproliferative disorders, all histological subtypes diagnosed from January 2015 to December 2022 will be enrolled. Tissue biopsied, immunophenotypic markers from consecutive patients at each site will be reviewed by panels of expert hematopathologists every year. So far, 381 cases were enrolled by 32 Brazilian centers, most of them are from the Southeast and South region. Twenty-two cases were not evaluable due to lack of complete data; hence, 359 were analyzed. The overall survival at 24-month was 52% (95% CI: 46-58%) and progression-free survival 37% (95% CI: 31-43%) with a median time of follow-up of 10 months (0.2-64). T-cell Brazil Project has many challenges to overcome, mainly due to its vast territory and its disparity. However, we already have another sixteen centers waiting for approval in their Ethics Committees. It was created a network around the country, mainly among the pathologists, with educational goals and exchange of experiences. It is crucial to obtain knowledge of local epidemiology to optimize resources, design clinical trials, and identify minority entities, contributing to increasing the quality o
    Type of Medium: Online Resource
    ISSN: 2469-2778
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.15406/htij.9.3
    DOI: 10.15406/htij
    DOI: 10.15406/htij.2021.09.00252
    Language: Unknown
    Publisher: MedCrave Group Kft.
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    C9orf72 Intermediate Repeats Confer Genetic Risk for Severe COVID-19 Pneumonia Independently of Age
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 13 ( 2021-06-29), p. 6991-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 13 ( 2021-06-29), p. 6991-
    Abstract: A cytokine storm, autoimmune features and dysfunctions of myeloid cells significantly contribute to severe coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Genetic background of the host seems to be partly responsible for severe phenotype and genes related to innate immune response seem critical host determinants. The C9orf72 gene has a role in vesicular trafficking, autophagy regulation and lysosome functions, is highly expressed in myeloid cells and is involved in immune functions, regulating the lysosomal degradation of mediators of innate immunity. A large non-coding hexanucleotide repeat expansion (HRE) in this gene is the main genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), both characterized by neuroinflammation and high systemic levels of proinflammatory cytokines, while HREs of intermediate length, although rare, are more frequent in autoimmune disorders. C9orf72 full mutation results in haploinsufficiency and intermediate HREs seem to modulate gene expression as well and impair autophagy. Herein, we sought to explore whether intermediate HREs in C9orf72 may be a risk factor for severe COVID-19. Although we found intermediate HREs in only a small portion of 240 patients with severe COVID-19 pneumonia, the magnitude of risk for requiring non-invasive or mechanical ventilation conferred by harboring intermediate repeats 〉 10 units in at least one C9orf72 allele was more than twice respect to having shorter expansions, when adjusted for age (odds ratio (OR) 2.36; 95% confidence interval (CI) 1.04–5.37, p = 0.040). The association between intermediate repeats 〉 10 units and more severe clinical outcome (p = 0.025) was also validated in an independent cohort of 201 SARS-CoV-2 infected patients. These data suggest that C9orf72 HREs 〉 10 units may influence the pathogenic process driving more severe COVID-19 phenotypes.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms22136991
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 6
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    Online Resource
    Survival analysis of penile cancer patients treatedat a tertiary oncology hospital
    FapUNIFESP (SciELO) ; 2018
    In:  Ciência & Saúde Coletiva Vol. 23, No. 8 ( 2018-08), p. 2479-2486
    Details
    In: Ciência & Saúde Coletiva, FapUNIFESP (SciELO), Vol. 23, No. 8 ( 2018-08), p. 2479-2486
    Abstract: Resumo O objetivo deste artigo é estimar a sobrevida específica dos pacientes com câncer de pênis atendidos em um hospital de referência em oncologia. Analisou-se 100 casos incidentes de pacientes com câncer de pênis que receberam tratamento no hospital, no período de 2000 a 2011, seguimento até 31 de dezembro de 2012. Utilizou-se como fonte de informação o banco de dados do Registro Hospitalar de Câncer e o prontuário do paciente. Utilizou-se o método de Kaplan-Meier para estimar a sobrevida e o modelo de Cox para investigar os fatores prognósticos. Todos possuíam histologia para câncer do pênis como base para o diagnóstico da doença. Para localização do tumor 75% não foram especificados, seguido de 18% na glande, 04% no prepúcio. O tempo mediano de sobrevida foi de 49 meses, 89% apresentavam-se entre os estádios I e II. Pacientes com ocupação rural apresentaram sobrevida média de 75,02 meses, ocupação não rural de 42,14 meses. Os procedentes da Grande Vitória – Espírito Santo sobrevida média de 26,03 e demais pacientes de 71,42 meses. Homens com linfonodo positivo possuíram sobrevida média de 30,59 meses e, sem comprometimento, 75,83 meses. A presença de metástase esteve associada a menores taxas de sobrevida. Trabalhadores não rurais, proveniente da Grande Vitória, com presença de linfonodo acometido e metástase apresentaram pior sobrevida.
    Type of Medium: Online Resource
    ISSN: 1678-4561 , 1413-8123
    URL: Article
    DOI: 10.1590/1413-81232018238.17692016
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2018
    detail.hit.zdb_id: 2078799-6
    SSG: 7,36
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