In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 71, No. 3-4 ( 2017), p. 136-144
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 β-Thalassemia major, the most common inherited anemia in the world, is associated with imbalance in the oxidant-antioxidant system. The objective of this study was to evaluate the efficacy of curcumin supplementation on markers of oxidative stress in patients with β-Thalassemia. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This double-blind randomized controlled clinical trial was performed on 61 β-thalassemia major patients. Subjects in the curcumin group received two 500 mg curcumin capsules daily and patients in the placebo group took 2 placebo capsules daily for 12 weeks. Dietary intakes and biochemical parameters were assessed at the beginning and the end of intervention. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At the end of the study, serum malondialdehyde (MDA), total and direct bilirubin significantly decreased ( 〈 i 〉 p 〈 /i 〉 = 0.002, 〈 i 〉 p 〈 /i 〉 〈 0.001, and 〈 i 〉 p 〈 /i 〉 〈 0.001, respectively) and total antioxidant capacity significantly increased ( 〈 i 〉 p 〈 /i 〉 = 0.005) in the curcumin group. Based on the analysis of covariance, a significant reduction in MDA, total and direct bilirubin was also detected in the curcumin group when compared to the placebo group ( 〈 i 〉 p 〈 /i 〉 = 0.001, 〈 i 〉 p 〈 /i 〉 = 0.039, and 〈 i 〉 p 〈 /i 〉 = 0.013, respectively). Changes in hemoglobin, serum iron, ferritin, catalase, and vitamin E were not significant in any of the 2 groups. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Curcumin supplementation in combination with deferoxamin improved the antioxidant status in β-thalassemia major patients. Curcumin may be useful for the relief of metabolic complications in these patients.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2017
detail.hit.zdb_id:
1481977-6
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