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  • 1
    Online Resource
    Online Resource
    The effects of respiratory exercises on partial pressures of gases and anxiety in the acute phase of COVID-19 infection
    Informa UK Limited ; 2022
    In:  Physiotherapy Theory and Practice Vol. 38, No. 13 ( 2022-11-18), p. 2736-2744
    Details
    In: Physiotherapy Theory and Practice, Informa UK Limited, Vol. 38, No. 13 ( 2022-11-18), p. 2736-2744
    Type of Medium: Online Resource
    ISSN: 0959-3985 , 1532-5040
    URL: Article
    DOI: 10.1080/09593985.2021.1996497
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2039101-8
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  • 2
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    Online Resource
    TGF-Β as a Marker of Ulcerative Colitis and Disease Severity
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2018
    In:  Serbian Journal of Experimental and Clinical Research Vol. 19, No. 3 ( 2018-09-01), p. 229-236
    Details
    In: Serbian Journal of Experimental and Clinical Research, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 19, No. 3 ( 2018-09-01), p. 229-236
    Abstract: Ulcerative colitis (UC) represents chronic inflammation of the large intestine. Immune response plays an important role in disease genesis and progression. Activated leukocytes secrete several cytokines that actively regulate the inflammatory response in UC. The aim of this study was to determine levels of cytokines IL-17, IL-27, IFN-γ and TGF-β in patients with UC and to test them as biomarkers for disease. The blood samples of 24 patients with ulcerative colitis without previous treatment and 37 healthy individuals were analyzed. Serum levels of IL-17, IL-27, IFN-γ and TGF-β were measured using sensitive enzyme-linked immunosorbent assay (ELISA) kits. Serum levels of IL-17, IL-27, IFN-γ and TGF-β were increased in patients with UC, compared to healthy controls (p=0.022; p=0.001; p=0.001; and p=0.002; respectively). Ratios of cytokines IL-27/IL-17, IFN-γ/TGF-β and IL-17/TGF-β were significantly higher in group of patients with UC (p=0.002; p=0.002; p=0.003; respectively). Serum value of TGF-β higher than 20 pg/ml presents a highly sensitive and specific marker for UC. We believe that increased production and predominance of immunosupressive TGF-β may represent compensatory mechanism for ongoing pro-inflammatory processes in UC.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.1515/sjecr-2017-0019
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2018
    detail.hit.zdb_id: 2710266-X
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  • 3
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    Online Resource
    Modelling Creep (Relaxation) of the Urinary Bladder
    Walter de Gruyter GmbH ; 2017
    In:  Serbian Journal of Experimental and Clinical Research Vol. 18, No. 4 ( 2017-12-1), p. 295-306
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 18, No. 4 ( 2017-12-1), p. 295-306
    Abstract: We first present the results of an experiment in which the passive properties of the urinary bladder were investigated using strips of rabbit bladder. Under the assumption that the urinary bladder had orthopaedic characteristics, the strips were taken in the longitudinal and in the circumferential directions. The material was subjected to uniaxial tension, and stress-stretch curves were generated for various rates of deformation. We found that the rates did not have a significantly effect on the passive response of the material. Additionally, the stress-stretch dependence during relaxation of the material when exposed to isometric conditions was determined experimentally. Next, we measured nonlinear stress-stretch dependence to determine the coefficients for this dependence in analytical form using a standard fitting procedure. The same approach was used to obtain the coefficients for the relaxation curves from the experimental data. Two constitutive laws, the nonlinear model for passive response and the creep model, were introduced within the shell finite element for geometrically and materially nonlinear analysis. We provide descriptions of the numerical procedures that were performed by considering the urinary bladder as a thin-walled shell structure subjected to pressure loading. The developed numerical algorithm for the incremental-iterative solution was implemented into the finite element program, PAK. The response of the urinary bladder was calculated for continuous filling, and the numerical and experimental results were compared through cystometrograms (pressure-volume relationships). We also present comparisons of the shapes and volumes of the urinary bladder obtained numerically and experimentally. Finally, the numerical results of the creep response, when placed under constant internal pressure, are provided for various stages of deformation.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.1515/sjecr-2016-0067
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2710266-X
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  • 4
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    Online Resource
    Rene Favaloro: A surgeon who has changed the history of coronary disease
    National Library of Serbia ; 2006
    In:  Medical review Vol. 59, No. 5-6 ( 2006), p. 281-285
    Details
    In: Medical review, National Library of Serbia, Vol. 59, No. 5-6 ( 2006), p. 281-285
    Abstract: Rene Favaloro je jedan od najznacajnijih hirurga 20. veka. Prvi je objavio u medicinskoj literaturi tehniku izvodjenja aortokoronarnog premoscavanja, kojom je pocela nova era u lecenju koronarne bolesti. Radeci na Cleveland klinici, zajedno sa Masonom Sonesom i Efflerom, nakon velikog broja operacija na otvorenom srcu i koronarografija, bio je deo tima koji ce prvi uraditi aortokoronarno premoscavanje, a nakon toga i koronarografski dokazati funkcionalnost anastomoze. Pet godina nakon njegove smrti, u vreme sve cesce upotrebe perkutane implantacije stentova, aortokoronarno premoscavanje je i dalje, za pojedine grupe pacijenata, metoda izbora lecenja koronarne bolesti. U vremenu kada i u nasoj zemlji pocinje da radi sluzba hitnih perkutanih intervencija u akutnom infarktu miokarda, o cemu je Rene Favaloro sa Masonom Sonesom diskutovao i zagovarao agresivno lecenje infarkta u njegovoj ranoj fazi, nagovestivsi potrebu razvijanja slicne metode, secamo se zivotnih i profesionalnih uspeha kardiohirurga koji je promenio dotadasnji tok koronarne bolesti. .
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS0606281Z
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2006
    detail.hit.zdb_id: 2381028-2
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  • 5
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    Online Resource
    Preoperative echocardiographic parameters influencing quality of life five years after coronary artery bypass graft surgery
    National Library of Serbia ; 2009
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 66, No. 9 ( 2009), p. 718-723
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 66, No. 9 ( 2009), p. 718-723
    Abstract: Uvod/Cilj. Upotreba Parsonnet skora u proceni postoperativnog trenda mortaliteta bolesnika nakon hirurske revaskularizacije miokarda vec je standardno dobro poznat model predikcije koji je nasao svoje mesto u svim svetskim kardiohirurskim centrima. Cilj naseg rada bio je da se proceni njihov uticaj na kvalitet zivota bolesnika pet godina nakon hirurske revaskularizacije miokarda, kao i da se ispita prediktivna vrednost skora kvaliteta zivota u poredjenju sa vec siroko koriscenim Paronnet skorom predikcije mortaliteta. Metode. Studija je obuhvatila 449 bolesnika, kod kojih je u toku 1999. i 2000. godine izvrsena hirurska revaskularizacija miokarda. Izuzeti su bolesnici kod kojih je istovremeno izvrsena i operacija zaliska, bolesnici sa komorbiditetima ili bez kompletne revaskularizacije miokarda. Sezdeset meseci posle operacije izvrsena je analiza kvaliteta zivota koriscenjem upitnika SF-36. Analizirano je sedam aspekata kvaliteta zivota, kao i ehokardiografski parametri i njihova korelacija sa aspektima kvaliteta zivota. Rezultati. Petogodisnje prezivljavanje iznosilo je 84,2%. Prosecni enddijastolni dijametar (EDD) je 55,3 ? 5,6 mm, endsistolni dijametar (ESD) 38,7 ? 5,6 mm, ejekciona frakcija (EF) 51,7 ? 9,6%. Dilatacija leve pretkomore, leve komore, ejekciona frakcija, multisegmentni ispadi u kontraktilnosti i umereno teska mitralna regurgitacija bili su u negativnoj korelaciji sa svim aspektima kvaliteta zivota (p 〈 0,001). Kriticne eokardiografske vrednosti za optimalni kvalitet zivota bili su EDD 〉 54,5 mm (senzitivnost 57%, specificnost 70%, RR = 1,386), ESD 〉 37,5 mm (senzitivnost 65%, specificnost 57% RR = 0,855), a EF 〈 50% ima najjacu prediktivnu vrednost (senzitivnost 61%, specificnost 70%, RR = 0,916). Zakljucak. Predperativni ehokardiogarfski parametri imaju vrlo visoku prediktivnu vrednost ne samo za postoperativno prezivljavanje vec i za kvalitet zivota bolesnika posle hirurske revaskularizacije miokarda.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP0909718Z
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2009
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 6
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    Coronary artery bypass surgery in patients with low EuroSCORE preoperative risk
    Walter de Gruyter GmbH ; 2012
    In:  Open Medicine Vol. 7, No. 3 ( 2012-06-1), p. 388-395
    Details
    In: Open Medicine, Walter de Gruyter GmbH, Vol. 7, No. 3 ( 2012-06-1), p. 388-395
    Abstract: Patients with EuroSCORE 〈 2 are usually considered to have a low surgical risk and the lowest mortality. In our study preoperative factors in a group of 250 consecutive low-risk patients (EuroSCORE 〈 2), who underwent first isolated coronary artery by-pass surgery during 1999 and 2000., were analyzed. Cumulative follow-up period was 1178.48 patient-years and the primary clinical outcome was all-cause mortality. Patients’ average age was 59.2±7.5 yr. The following preoperative risk factors of increased 5-year mortality were identified: older age (P 〈 0.001), smoking, prior non-recent myocardial infarction and reinfarction, anteroseptal localization of myocardial infarction (P 〈 0.001), poor ejection fraction 〈 =35% (P 〈 0.001), dilatative cardiomyopathy (P 〈 0.001), wall motion systolic index 〉2 (P 〈 0.001), left atrial dilatation (P 〈 0.001), mitral regurgitation more than 2+ (P 〈 0.001), presence of left main disease, triple vessel coronary artery disease (P 〈 0.001), absence of collaterals (P 〈 0.001) and presence of more than 3 distal anastomoses. Through the present study it has been shown that it is possible to identify a subgroup of patients with low operative mortality and excellent 5-year survival after surgical treatment for coronary artery bypass surgery using preoperative clinical, echocardiographic, coronarographic and intraoperative data, even in difficult conditions of the civil war in the region.
    Type of Medium: Online Resource
    ISSN: 2391-5463
    URL: Article
    DOI: 10.2478/s11536-011-0164-4
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2012
    detail.hit.zdb_id: 2829380-0
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  • 7
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    Online Resource
    Systemic lupus erythematosus: From etiopatogenesis to up to date treatment's methods
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2019
    In:  Timocki medicinski glasnik Vol. 44, No. 1 ( 2019), p. 26-30
    Details
    In: Timocki medicinski glasnik, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 44, No. 1 ( 2019), p. 26-30
    Type of Medium: Online Resource
    ISSN: 0350-2899 , 2406-1042
    Uniform Title: Sistemski lupus eritematodus - od etiopatogeneze do savremenih metoda lečenja
    URL: Article
    DOI: 10.5937/tmg1901026Z
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2019
    detail.hit.zdb_id: 2433190-9
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  • 8
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    Respiratory Rehabilitation Improves Quality of Life and Functionality of Covid 19 Patients
    Walter de Gruyter GmbH ; 2023
    In:  Experimental and Applied Biomedical Research (EABR) Vol. 0, No. 0 ( 2023-08-04)
    Details
    In: Experimental and Applied Biomedical Research (EABR), Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2023-08-04)
    Abstract: Respiratory rehabilitation leads to reduction of symptoms, strengthens extremity musculature and improves emotional state and management of daily activities in patients with respiratory diseases. Aim of our study was to determine quality of life and functionality of COVID 19 patients before and after respiratory rehabilitation program. The study was conducted at the Clinical Center, Kragujevac, from June to July 2020. The study was a prospective clinical trial and included 62 patients with the acutephase of COVID-19. Respiratory rehabilitation program started at hospital and continued at home for three months overall. Quality of life was measured by the EQ-5D-5L and patient’s functionality by The FIM score. All five dimension of EQ-5D-5L were higher after respiratory rehabilitation program as well as EQ-5D index score and VAS score (0.8516±0.202 and 53.31±17.129 before rehabilitation, 0.9147±0.074 and 64.53±8.368 after rehabilitation). Respiratory exercise showed significantly improvement in FIM total score from 104.48±12.880 to 106.21±9.791, as well as in FIM motor and cognitive subscores. Respiratory rehabilitation program improves quality of life and functionality of COVID 19 patients.
    Type of Medium: Online Resource
    ISSN: 2956-0454
    URL: Article
    DOI: 10.2478/eabr-2023-0002
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
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  • 9
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    Online Resource
    Treatment of Ulcerative Colitis: Impact on Platelet Aggregation
    MDPI AG ; 2023
    In:  Medicina Vol. 59, No. 9 ( 2023-09-07), p. 1615-
    Details
    In: Medicina, MDPI AG, Vol. 59, No. 9 ( 2023-09-07), p. 1615-
    Abstract: Background and Objectives: Ulcerative colitis is chronic and/or progressive inflammation of the colorectal mucosa and submucosa and represents one of two major inflammatory bowel diseases. Ulcerative colitis has been associated with increased risk of arteriosus and venous thrombosis. There are numerous factors responsible for this; one of them is platelet activation and aggregation. The objective of our study was to determine if different treatment options for ulcerative colitis have an impact on platelet aggregation. Materials and Methods: This research was a prospective, observational study and included 94 newly diagnosed patients with UC divided into four treatment groups. For all patients, we measured platelet aggregability by using an impedance aggregometry method with a multiplate analyzer before and after treatment with infliximab, adalimumab, vedolizumab and azathioprine. A Paired Samples t test was performed in order to determine the difference in platelet aggregability before and after a certain therapy, since the data followed a normal distribution. Taking into account the impact of some clinical characteristics, multiple linear regression was conducted for the purpose of estimating the effect of therapy on the level of reduction in platelet aggregability. Results: All four drugs significantly reduced platelet aggregability. After we excluded the influence of clinical and endoscopic scores and disease localization on the results, we found that infliximab had the greatest anti-platelet activity. Conclusions: In addition to the well-known traditional risk factors for atherosclerosis, activation and aggregation of platelets play a significant role in the development of arterial thrombosis, and our results suggested that therapy use for the treatment of UC, especially infliximab, can have a great impact on cardiovascular morbidity and mortality by decreasing platelet aggregability.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina59091615
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2088820-X
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  • 10
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    Online Resource
    Cardiopulmonary cerebral resuscitation of children
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2018
    In:  Timocki medicinski glasnik Vol. 43, No. 4 ( 2018), p. 193-197
    Details
    In: Timocki medicinski glasnik, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 43, No. 4 ( 2018), p. 193-197
    Type of Medium: Online Resource
    ISSN: 0350-2899 , 2406-1042
    Uniform Title: Kardiopulmonalno cerebralna reanimacija dece
    URL: Article
    DOI: 10.5937/tmg1804193Z
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2018
    detail.hit.zdb_id: 2433190-9
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