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CACA guidelines for holistic integrative management of rectal cancer

Committee of Colorectal Cancer Society Chinese Anti-Cancer Association ; Wang, Guiyu ; Fan, Daiming ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Holistic Integrative Oncology Vol. 2, No. 1 ( 2023-02-21)

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In: Holistic Integrative Oncology, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2023-02-21)

Abstract: Colorectal cancer is a common malignant tumor worldwide. In China, the ratio of rectal cancer to colon cancer in terms of incidence is close to 1: 1. Low rectal cancer accounts for more than half of all cases of rectal cancer. In recent years, the proportion of rectal cancer has trended downward, however the incidence of rectal cancer in younger adults is increasing. The CACA Guidelines for Holistic Integrative Management of Rectal Cancer were edited to help improve the diagnosis and comprehensive treatment in China. Methods This guideline has been prepared by consensuses reached by the CACA Committee of Colorectal Cancer Society, based on a careful review of the latest evidence including China’s studies, and referred to domestic and international relative guidelines, also considered China’s specific national conditions and clinical practice. Results The CACA Guidelines for Holistic Integrative Management of Rectal Cancer include the epidemiology of rectal cancer, prevention and screening, diagnosis, treatment of nonmetastatic and metastatic rectal cancer, follow-up, and whole-course rehabilitation management. Conclusion Committee of Colorectal Cancer Society, Chinese Anti-Cancer Association, standardizes the diagnosis and treatment of rectal cancer in China through the formulation of the CACA Guidelines.

Type of Medium: Online Resource

ISSN: 2731-4529

URL: Article

DOI: 10.1007/s44178-023-00023-2

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

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Gut Microbiome Alterations in Men Who Have Sex with Men-A Preliminary Report

Zhang, Zhihua ; Lu, Xiaoyan ; Zhang, Kexin ; [et al.]

Bentham Science Publishers Ltd. ; 2022

In: Current HIV Research Vol. 20, No. 5 ( 2022-09), p. 407-418

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In: Current HIV Research, Bentham Science Publishers Ltd., Vol. 20, No. 5 ( 2022-09), p. 407-418

Abstract: Studies have found that HIV is mainly transmitted through the mucosal surface, and the entrance of early progression of the disease is the rectal and colonic mucosa. So, this paper aimed to explore and analyze the structural differences of gut microbiome between men who have sex with men (MSM) and those who don’t have sex with men (Non-MSM), expecting to find novel biological factors that potentially impact transmission and/or disease in MSM population. Methods: We collected a total of 33 stool samples, 16 were MSM and 17 were Non-MSM. The 16S rRNA gene amplification sequencing was used to detect the alteration and structure of the gut microbiome community in two groups. Results: The difference in β diversity of gut microbiome of two groups of subjects was statistically significant (P 〈 0.001), indicating that the difference in the structure of the gut microbiome of two groups was statistically significant. Compared with the phylum and genus level of Non-MSM group, the relative abundances of Actinobacteria, Proteobacteria, genera Collinsella, Prevotella, Bifidobacterium and Ralstonia in MSM group were higher (P 〈 0.001, P 〈 0.05, LDA score (log10) 〉 2), and the relative abundance of Bacteroidetes, genera Erysipelotrichaceae incertae sedis, Bilophila, Holdemania, Clostridium XIVb and Bacteroidaceae in MSM group were lower (P 〈 0.01, LDA score (log10) 〉 2). Conclusions: There are some differences in the structure of gut microbiome between MSM group and Non-MSM group. It indicates the differences in behavior and characteristics between MSM and Non-MSM populations may be related to the difference in the structure of gut microbiome.

Type of Medium: Online Resource

ISSN: 1570-162X

URL: Article

DOI: 10.2174/1570162X20666220908105918

Language: English

Publisher: Bentham Science Publishers Ltd.

Publication Date: 2022

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A randomized trial of pegylated recombinant human granulocyte-colony stimulating factor to prevent febrile neutropenia in breast cancer after chemotherapy.

Zhang, Lina ; Li, Yuntao ; Fan, Zhonglin ; [et al.]

American Society of Clinical Oncology (ASCO) ; 2022

In: Journal of Clinical Oncology Vol. 40, No. 16_suppl ( 2022-06-01), p. e12516-e12516

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In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 16_suppl ( 2022-06-01), p. e12516-e12516

Abstract: e12516 Background: The purpose of this study was to evaluate the incidence of febrile neutropenia (FN) in breast cancer patients with pegylated recombinant human granulocyte-colony stimulating factor (PEG-rhG-CSF) administration at 48 or 24 hours after chemotherapy for primary prevention. Methods: Patients with stage I-III invasive breast cancer who were scheduled to receive 4 cycles of adjuvant chemotherapy with EC regimen (epirubicin combined with cyclophosphamide) were eligible for this multicenter, open-label, randomized trial. Patients were randomized (1:1) to receive PEG-rhG-CSF (Jinyouli) 48 hours (48h group) or 24 hours (24h group) after the end of each cycle of chemotherapy. The primary endpoint was the incidence rate of FN. The secondary endpoints included the incidence rates of grade 3/4 neutropenia, chemotherapy dose reduction and chemotherapy delay due to neutropenia, antibiotic administration, the pain (bone, muscle, or joint), and the relative dose intensity (RDI) of the chemotherapy. Results: The preliminary results enrolled 197 patients including 96 in the 48h group and 101 in the 24h group. 78.1% of 48h group patients and 73.3% of 24h group patients completed four cycles of chemotherapy. The incidence rates of FN were 2.1% in the 48h group and 4.0% in the 24h group respectively. FN occurred in the first two cycles in the 48h group, while in the 24h group, it occurred only in the first cycles. The incidence rate of grade 3/4 neutropenia was 27.1% in the 48h group and 51.5% in the 24h group respectively. There was no delay in chemotherapy due to neutropenia in the two groups. The incidence rate of chemotherapy dose reduction due to neutropenia was 2.1% in the 48h group and 1.0% in the 24h group respectively. 2 (2.1%) patients in the 48h group and 4 (4.0%) patients in the 24h group received antibiotics. The mean RDI of each cycle of chemotherapy was 91.3% in the 48h group and 91.5% in the 24h group, respectively. The incidence rate of all grades pain (bone, muscle, or joint) was 25.0% in the 48h group, and 20.8% in the 24h group. With regard to 3 or higher grade pain, 1 (1.0%) patient in the 48h group experienced bone pain and 1 (1.0%) patient in the 24h group experienced muscle pain. Conclusions: Preliminary results suggest a similar effect of PEG-rhG-CSF administration at 48 or 24 hours after chemotherapy in primary prevention of FN in breast cancer patients receiving EC chemotherapy regimen. Recruitment is ongoing and updated data will be presented. Clinical trial information: ChiCTR1800019516. [Table: see text]

Type of Medium: Online Resource

ISSN: 0732-183X , 1527-7755

URL: Article

DOI: 10.1200/JCO.2022.40.16_suppl.e12516

RVK:

XA 52760

RVK:

XA 10000

Language: English

Publisher: American Society of Clinical Oncology (ASCO)

Publication Date: 2022

detail.hit.zdb_id: 2005181-5

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Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry

Yuan, Jiao ; Kensler, Kevin H. ; Hu, Zhongyi ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Genetics Vol. 16, No. 2 ( 2020-2-14), p. e1008641-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2020-2-14), p. e1008641-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1008641

DOI: 10.1371/journal.pgen.1008641.g001

DOI: 10.1371/journal.pgen.1008641.g002

DOI: 10.1371/journal.pgen.1008641.g003

DOI: 10.1371/journal.pgen.1008641.g004

DOI: 10.1371/journal.pgen.1008641.g005

DOI: 10.1371/journal.pgen.1008641.s001

DOI: 10.1371/journal.pgen.1008641.s002

DOI: 10.1371/journal.pgen.1008641.s003

DOI: 10.1371/journal.pgen.1008641.s004

DOI: 10.1371/journal.pgen.1008641.s005

DOI: 10.1371/journal.pgen.1008641.s006

DOI: 10.1371/journal.pgen.1008641.s007

DOI: 10.1371/journal.pgen.1008641.s008

DOI: 10.1371/journal.pgen.1008641.s009

DOI: 10.1371/journal.pgen.1008641.s010

DOI: 10.1371/journal.pgen.1008641.s011

DOI: 10.1371/journal.pgen.1008641.s012

DOI: 10.1371/journal.pgen.1008641.s013

DOI: 10.1371/journal.pgen.1008641.s014

DOI: 10.1371/journal.pgen.1008641.s015

DOI: 10.1371/journal.pgen.1008641.s016

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2186725-2

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Conductive polyaniline-graphene oxide sorbent for electrochemically assisted solid-phase extraction of lead ions in aqueous food samples

Wang, Jing ; Zhu, Wenxin ; Zhang, Tianshu ; [et al.]

Elsevier BV ; 2020

In: Analytica Chimica Acta Vol. 1100 ( 2020-03), p. 57-65

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In: Analytica Chimica Acta, Elsevier BV, Vol. 1100 ( 2020-03), p. 57-65

Type of Medium: Online Resource

ISSN: 0003-2670

URL: Article

DOI: 10.1016/j.aca.2019.11.070

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 52-8

detail.hit.zdb_id: 1483436-4

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Correction to: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression

Liu, Hongtao ; Zhang, Qing ; Song, Yinsen ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Journal of Experimental & Clinical Cancer Research Vol. 40, No. 1 ( 2021-10-19)

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In: Journal of Experimental & Clinical Cancer Research, Springer Science and Business Media LLC, Vol. 40, No. 1 ( 2021-10-19)

Abstract: An amendment to this paper has been published and can be accessed via the original article.

Type of Medium: Online Resource

ISSN: 1756-9966

URL: Article

DOI: 10.1186/s13046-021-02123-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2430698-8

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Retraction Note: Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression

Liu, Hongtao ; Zhang, Qing ; Song, Yinsen ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Journal of Experimental & Clinical Cancer Research Vol. 42, No. 1 ( 2023-03-09)

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In: Journal of Experimental & Clinical Cancer Research, Springer Science and Business Media LLC, Vol. 42, No. 1 ( 2023-03-09)

Abstract: This article has been retracted. Please see the Retraction Notice for more detail: https://10.1186/s13046-021-02081-8.

Type of Medium: Online Resource

ISSN: 1756-9966

URL: Article

DOI: 10.1186/s13046-023-02632-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2430698-8

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PTPN9 dephosphorylates FGFR2pY656/657 via interaction with ACAP1 and ameliorates pemigatinib effect in cholangiocarcinoma

Zhao, Liming ; Liu, Jialiang ; Li, Kangshuai ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2023

In: Hepatology

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In: Hepatology, Ovid Technologies (Wolters Kluwer Health)

Abstract: Cholangiocarcinoma (CCA) is a highly aggressive and lethal cancer that originates from biliary epithelium. Systemic treatment options for CCA are currently limited, and the first targeted drug of CCA, pemigatinib, emerged till 2020 for CCA treatment by inhibiting FGFR2 phosphorylation. However, the regulatory mechanism of FGFR2 phosphorylation is not fully elucidated. Here we screened the FGFR2-interacting proteins and showed that protein tyrosine phosphatase N9 (PTPN9) interacts with FGFR2 and negatively regulates FGFR2 pY656/657 . Using phosphatase activity assays and modeling the FGFR2-PTPN9 complex structure, we identified FGFR2 pY656/657 as a substrate of PTPN9, and found that sec. 14p domain of PTPN9 interacts with FGFR2 via ACAP1 mediation. Co-expression of PTPN9 and ACAP1 indicates a favorable prognosis for CCA. Additionally, we identified key amino acids and motifs involved in sec. 14p-APCP1-FGFR2 interaction, including the “YRETRRKE” motif of sec. 14p, Y471 of PTPN9, as well as the PH and Arf-GAP domain of ACAP1. Moreover, we discovered that the FGFR2 I654V substitution can decrease PTPN9-FGFR2 interaction and thereby reduce the effectiveness of pemigatinib treatment. Using a series of in vitro and in vivo experiments including PDX, we showed that PTPN9 synergistically enhances pemigatinib effectiveness and suppresses CCA proliferation, migration, and invasion by inhibiting FGFR2 pY656/657 . In conclusion, our study identifies PTPN9 as a negative regulator of FGFR2 phosphorylation and a synergistic factor for pemigatinib treatment. The molecular mechanism, oncogenic function and clinical significance of PTPN9-ACAP1-FGFR2 complex are revealed, providing more evidence for CCA precision treatment.

Type of Medium: Online Resource

ISSN: 0270-9139

URL: Article

DOI: 10.1097/HEP.0000000000000552

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2023

detail.hit.zdb_id: 1472120-X

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Preparation of low remanence temperature coefficient (RT – 300 °C) SmDy (Co, Fe, Cu, Zr)z magnets and molecular field analysis

Zhang, Tianli ; Zhang, Bo ; Wang, Hui ; [et al.]

Elsevier BV ; 2018

In: Journal of Magnetism and Magnetic Materials Vol. 466 ( 2018-11), p. 38-43

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In: Journal of Magnetism and Magnetic Materials, Elsevier BV, Vol. 466 ( 2018-11), p. 38-43

Type of Medium: Online Resource

ISSN: 0304-8853

URL: Article

DOI: 10.1016/j.jmmm.2018.06.048

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1479000-2

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An updated of meta-analysis on the relationship between mobile phone addiction and sleep disorder

Zhang, Jianghui ; Zhang, Xueqing ; Zhang, Kexin ; [et al.]

Elsevier BV ; 2022

In: Journal of Affective Disorders Vol. 305 ( 2022-05), p. 94-101

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In: Journal of Affective Disorders, Elsevier BV, Vol. 305 ( 2022-05), p. 94-101

Type of Medium: Online Resource

ISSN: 0165-0327

URL: Article

DOI: 10.1016/j.jad.2022.02.008

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 1500487-9

SSG: 12

SSG: 5,2

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