In:
Obesity, Wiley, Vol. 25, No. 4 ( 2017-04), p. 757-764
Abstract:
Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat‐induced obesity, a genome‐wide association meta‐analysis of BFM, after adjustment by body lean mass, was performed in the European population. Methods Three samples of European ancestry were included in the meta‐analysis: the Framingham Heart Study ( N = 6,004), the Kansas City osteoporosis study ( N = 2,207), and the Omaha osteoporosis study ( N = 968). Results At the genome‐wide significance level (α = 5.0×10 −8 ), a cluster of 10 single‐nucleotide polymorphisms (SNPs) at chromosomal region 20p11 that were associated with BFM (lead SNP rs2069126, P = 1.82×10 −9 , closest gene SLC24A3 ) was identified in 9,179 subjects. One of the top SNPs, rs6046308 ( P = 3.74×10 −8 ), was found to be nominally significant for body fat percentage in another independent study (P = 0.03, N = 75,888) and was reported to transregulate the expression of the MPZ gene at 1q23.3 (unadjusted P = 9.78×10 −6 , N = 1,490). Differential gene expression analysis demonstrated that SLC24A3 and CFAP61 at the identified locus were differentially expressed in tissues of people with versus without obesity (P = 3.40×10 −5 and 8.72×10 −4 , N = 126 and 70), implying their potential role in fat development. Conclusions These results may provide new insights into the biological mechanism that underlies fat‐induced obesity pathology.
Type of Medium:
Online Resource
ISSN:
1930-7381
,
1930-739X
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2027211-X
Bookmarklink