In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 6 ( 2021-6-10), p. e0009501-
Abstract:
Shigellosis is a heavy disease burden in China especially in children aged under 5 years. However, the age-related factors involved in transmission of shigellosis are unclear. An age-specific Susceptible–Exposed–Infectious/Asymptomatic–Recovered (SEIAR) model was applied to shigellosis surveillance data maintained by Hubei Province Centers for Disease Control and Prevention from 2005 to 2017. The individuals were divided into four age groups (≤ 5 years, 6–24 years, 25–59 years, and ≥ 60 years). The effective reproduction number ( R eff ), including infectivity ( R I ) and susceptibility ( R S ) was calculated to assess the transmissibility of different age groups. From 2005 to 2017, 130,768 shigellosis cases were reported in Hubei Province. The SEIAR model fitted well with the reported data ( P 〈 0.001). The highest transmissibility ( R eff ) was from ≤ 5 years to the 25–59 years (mean: 0.76, 95% confidence interval [CI]: 0.34–1.17), followed by from the 6–24 years to the 25–59 years (mean: 0.69, 95% CI: 0.35–1.02), from the ≥ 60 years to the 25–59 years (mean: 0.58, 95% CI: 0.29–0.86), and from the 25–59 years to 25–59 years (mean: 0.50, 95% CI: 0.21–0.78). The highest infectivity was in ≤ 5 years ( R I = 1.71), and was most commonly transmitted to the 25–59 years (45.11%). The highest susceptibility was in the 25–59 years ( R S = 2.51), and their most common source was the ≤ 5 years (30.15%). Furthermore, “knock out” simulation predicted the greatest reduction in the number of cases occurred by when cutting off transmission routes among ≤ 5 years and from 25–59 years to ≤ 5 years. Transmission in ≤ 5 years occurred mainly within the group, but infections were most commonly introduced by individuals in the 25–59 years. Infectivity was highest in the ≤ 5 years and susceptibility was highest in the 25–59 years. Interventions to stop transmission should be directed at these age groups.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009501
DOI:
10.1371/journal.pntd.0009501.g001
DOI:
10.1371/journal.pntd.0009501.g002
DOI:
10.1371/journal.pntd.0009501.g003
DOI:
10.1371/journal.pntd.0009501.g004
DOI:
10.1371/journal.pntd.0009501.g005
DOI:
10.1371/journal.pntd.0009501.g006
DOI:
10.1371/journal.pntd.0009501.g007
DOI:
10.1371/journal.pntd.0009501.g008
DOI:
10.1371/journal.pntd.0009501.g009
DOI:
10.1371/journal.pntd.0009501.g010
DOI:
10.1371/journal.pntd.0009501.g011
DOI:
10.1371/journal.pntd.0009501.t001
DOI:
10.1371/journal.pntd.0009501.t002
DOI:
10.1371/journal.pntd.0009501.t003
DOI:
10.1371/journal.pntd.0009501.s001
DOI:
10.1371/journal.pntd.0009501.s002
DOI:
10.1371/journal.pntd.0009501.s003
DOI:
10.1371/journal.pntd.0009501.s004
DOI:
10.1371/journal.pntd.0009501.s005
DOI:
10.1371/journal.pntd.0009501.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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