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Large-area 4H-SiC avalanche photodiodes with high gain and low dark current for visible-blind ultraviolet detection

Xingye Zhou, Xingye Zhou ; Jia Li, Jia Li ; Weili Lu, Weili Lu ; [et al.]

Shanghai Institute of Optics and Fine Mechanics ; 2018

In: Chinese Optics Letters Vol. 16, No. 6 ( 2018), p. 060401-

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In: Chinese Optics Letters, Shanghai Institute of Optics and Fine Mechanics, Vol. 16, No. 6 ( 2018), p. 060401-

Type of Medium: Online Resource

ISSN: 1671-7694

Uniform Title: Large-area 4H-SiC avalanche photodiodes with high gain and low dark current for visible-blind ultraviolet detection

URL: Issue

URL: Journal

URL: Article

DOI: 10.3788/COL/2018/16/6

DOI: 10.3788/COL

DOI: 10.3788/COL201816.060401

Language: English , Chinese

Publisher: Shanghai Institute of Optics and Fine Mechanics

Publication Date: 2018

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Long-Term Ozone Exposure and Small Airway Dysfunction: The China Pulmonary Health (CPH) Study

Niu, Yue ; Yang, Ting ; Gu, Xiaoying ; [et al.]

American Thoracic Society ; 2022

In: American Journal of Respiratory and Critical Care Medicine Vol. 205, No. 4 ( 2022-02-15), p. 450-458

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In: American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, Vol. 205, No. 4 ( 2022-02-15), p. 450-458

Type of Medium: Online Resource

ISSN: 1073-449X , 1535-4970

URL: Article

DOI: 10.1164/rccm.202107-1599OC

RVK:

XA 21200

Language: English

Publisher: American Thoracic Society

Publication Date: 2022

detail.hit.zdb_id: 1468352-0

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Imaging process and signal-to-noise ratio improvement of enhanced self-heterodyne synthetic aperture imaging ladar

Guo Zhang, Guo Zhang ; Jianfeng Sun, Jianfeng Sun ; Yu Zhou, Yu Zhou ; [et al.]

Shanghai Institute of Optics and Fine Mechanics ; 2017

In: Chinese Optics Letters Vol. 15, No. 10 ( 2017), p. 102801-

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In: Chinese Optics Letters, Shanghai Institute of Optics and Fine Mechanics, Vol. 15, No. 10 ( 2017), p. 102801-

Type of Medium: Online Resource

ISSN: 1671-7694

Uniform Title: Imaging process and signal-to-noise ratio improvement of enhanced self-heterodyne synthetic aperture imaging ladar

URL: Issue

URL: Journal

URL: Article

DOI: 10.3788/COL/2017/15/10

DOI: 10.3788/COL

DOI: 10.3788/COL201715.102801

Language: English , Chinese

Publisher: Shanghai Institute of Optics and Fine Mechanics

Publication Date: 2017

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Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023

CNCB-NGDC Members and Partners ; Xue, Yongbiao ; Bao, Yiming ; [et al.]

Oxford University Press (OUP) ; 2023

In: Nucleic Acids Research Vol. 51, No. D1 ( 2023-01-06), p. D18-D28

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In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 51, No. D1 ( 2023-01-06), p. D18-D28

Abstract: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global academic and industrial communities. With the explosive accumulation of multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands and updates core database resources by big data archive, integrative analysis and value-added curation. In the past year, efforts have been devoted to integrating multiple omics data, synthesizing the growing knowledge, developing new resources and upgrading a set of major resources. Particularly, several database resources are newly developed for infectious diseases and microbiology (MPoxVR, KGCoV, ProPan), cancer-trait association (ASCancer Atlas, TWAS Atlas, Brain Catalog, CCAS) as well as tropical plants (TCOD). Importantly, given the global health threat caused by monkeypox virus and SARS-CoV-2, CNCB-NGDC has newly constructed the monkeypox virus resource, along with frequent updates of SARS-CoV-2 genome sequences, variants as well as haplotypes. All the resources and services are publicly accessible at https://ngdc.cncb.ac.cn.

Type of Medium: Online Resource

ISSN: 0305-1048 , 1362-4962

URL: Article

DOI: 10.1093/nar/gkac1073

RVK:

WA 15000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 1472175-2

SSG: 12

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Efficacy and Safety of the Biosimilar IBI301 Plus Standard CHOP (I-CHOP) in Comparison With Rituximab Plus CHOP (R-CHOP) in Patients with Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL): A Randomized, Double-Blind, Parallel-Group, Phase 3 Trial

Song, Yuqin ; Zhou, Hui ; Zhang, Huilai ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Advances in Therapy Vol. 38, No. 4 ( 2021-04), p. 1889-1903

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In: Advances in Therapy, Springer Science and Business Media LLC, Vol. 38, No. 4 ( 2021-04), p. 1889-1903

Type of Medium: Online Resource

ISSN: 0741-238X , 1865-8652

URL: Article

DOI: 10.1007/s12325-020-01603-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2421646-X

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Value of D-dimer in predicting various clinical outcomes following community-acquired pneumonia: A network meta-analysis

Li, Jiawen ; Zhou, Kaiyu ; Duan, Hongyu ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 2 ( 2022-2-23), p. e0263215-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2022-2-23), p. e0263215-

Abstract: Whether high D-dimer level before treatment has any impact on poor outcomes in patients with community-associated pneumonia (CAP) remains unclear. Therefore, we conducted the first meta-analysis focusing specifically on prognostic value of high D-dimer level before treatment in CAP patients. Methods Pubmed, Embase, the Cochrane Central Register of Controlled Trials and World Health Organization clinical trials registry center were searched up to the end of March 2021. Randomized clinical trials (RCT) and observational studies were included to demonstrate the association between the level of D-dimer and clinical outcomes. Data were extracted using an adaptation of the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies (CHARMS-PF). When feasible, meta-analysis using random-effects models was performed. Risk of bias and level of evidence were assessed with the Quality in Prognosis Studies tool and an adaptation of Grading of Recommendations Assessment, Development, and Evaluation. Data were analyzed using STATA 14.0 to complete meta and network analysis. Main outcomes and measures Besides d-dimer levels in CAP patients with poor outcomes, we also analyzed proportion of patients with or without poor outcomes correctly classified by the d-dimer levels as being at high or low risk. The poor outcome includes severe CAP, death, pulmonary embolism (PE) and invasive mechanical ventilators. Results 32 studies with a total of 9,593 patients were eventually included. Pooled effect size (ES) suggested that d-dimer level was significantly higher in severe CAP patients than non-severe CAP patients with great heterogeneity (SMD = 1.21 95%CI 0.87–1.56, I 2 = 86.8% p = 0.000). D-dimer level was significantly elevated in non-survivors compared to survivors with CAP (SMD = 1.22 95%CI 0.67–1.77, I 2 = 85.1% p = 0.000). Prognostic value of d-dimer for pulmonary embolism (PE) was proved by hierarchical summary receiver operating characteristic curve (HSROC) with good summary sensitivity (0.74, 95%CI, 0.50–0.89) and summary specificity (0.82, 95%CI, 0.41–0.97). Network meta-analysis suggested that there was a significant elevation of d-dimer levels in CAP patients with poor outcome than general CAP patients but d-dimer levels weren’t significantly different among poor outcomes. Conclusion The prognostic ability of d-dimer among patients with CAP appeared to be good at correctly identifying high-risk populations of poor outcomes, suggesting potential for clinical utility in patients with CAP.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0263215

DOI: 10.1371/journal.pone.0263215.g001

DOI: 10.1371/journal.pone.0263215.g002

DOI: 10.1371/journal.pone.0263215.g003

DOI: 10.1371/journal.pone.0263215.g004

DOI: 10.1371/journal.pone.0263215.g005

DOI: 10.1371/journal.pone.0263215.g006

DOI: 10.1371/journal.pone.0263215.t001

DOI: 10.1371/journal.pone.0263215.t002

DOI: 10.1371/journal.pone.0263215.s001

DOI: 10.1371/journal.pone.0263215.s002

DOI: 10.1371/journal.pone.0263215.s003

DOI: 10.1371/journal.pone.0263215.s004

DOI: 10.1371/journal.pone.0263215.s005

DOI: 10.1371/journal.pone.0263215.s006

DOI: 10.1371/journal.pone.0263215.s007

DOI: 10.1371/journal.pone.0263215.s008

DOI: 10.1371/journal.pone.0263215.s009

DOI: 10.1371/journal.pone.0263215.s010

DOI: 10.1371/journal.pone.0263215.s011

DOI: 10.1371/journal.pone.0263215.s012

DOI: 10.1371/journal.pone.0263215.s013

DOI: 10.1371/journal.pone.0263215.s014

DOI: 10.1371/journal.pone.0263215.s015

DOI: 10.1371/journal.pone.0263215.s016

DOI: 10.1371/journal.pone.0263215.r001

DOI: 10.1371/journal.pone.0263215.r002

DOI: 10.1371/journal.pone.0263215.r003

DOI: 10.1371/journal.pone.0263215.r004

DOI: 10.1371/journal.pone.0263215.r005

DOI: 10.1371/journal.pone.0263215.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer

Zhou, Hongyu ; Qian, Weiping ; Uckun, Fatih M. ; [et al.]

American Chemical Society (ACS) ; 2015

In: ACS Nano Vol. 9, No. 8 ( 2015-08-25), p. 7976-7991

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In: ACS Nano, American Chemical Society (ACS), Vol. 9, No. 8 ( 2015-08-25), p. 7976-7991

Type of Medium: Online Resource

ISSN: 1936-0851 , 1936-086X

URL: Article

DOI: 10.1021/acsnano.5b01288

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2015

detail.hit.zdb_id: 2383064-5

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Abstract B67: Stroma breaking dual targeted theranostic nanoparticles for image-guided and targeted therapy of pancreatic cancer

Zhou, Hongyu ; Guo, Xiangxue ; Qian, Weiping ; [et al.]

American Association for Cancer Research (AACR) ; 2016

In: Cancer Research Vol. 76, No. 24_Supplement ( 2016-12-15), p. B67-B67

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In: Cancer Research, American Association for Cancer Research (AACR), Vol. 76, No. 24_Supplement ( 2016-12-15), p. B67-B67

Abstract: Low efficiency in drug delivery into pancreatic cancer cells due to the presence of a dense fibrotic tumor stromal barrier has been the major unmet clinical challenge for pancreatic cancer treatment. Drug delivery stromal barriers include irregular and insufficient tumor blood vessels, extensive fibroblasts, massive infiltration of tumor associated macrophages, and enriched fibrous stromal matrix. Building upon our understanding of pancreatic cancer biology and expertise in developing theranostic nanoparticles, we have developed a stroma breaking drug delivery nanoparticle platform with dual receptor targeting ability and protease activity for overcoming the above stromal barriers. Targeting urokinase plasminogen activator receptor (uPAR) that is expressed in angiogenic tumor endothelial cells, tumor stromal fibroblasts and macrophages, and invasive tumor cells facilitates nanoparticle extravasation, retention, intratumoral distribution and internalization into tumor stromal and pancreatic cancer cells. Co-targeting IGF-IR that is uniformly expressed at a very high level in all tumor cells as well as an intermediate level in tumor stromal cells enhances nanoparticle-drug delivery into drug resistant pancreatic cancer cells. Interactions of dual receptor targeted IONPs with uPAR and IGF-1R expressing tumor fibroblasts and macrophages ensure retention of the nanoparticles in the tumor stroma while MMP14 catalytic activity of the uPAR-targeting ATFMMP14 ligand breaks down the extracellular matrix and facilitates the migration of IONPs through the tumor stroma to reach cancer cells. Additionally, internalization of theranostic IONPs into tumor stromal cells leads to the stromal collapse and further enhances nanoparticle delivery into tumor cells. This dual targeted and protease activate IONP was produced by conjugation of the recombinant amino terminal fragment (ATF) of uPA and catalytic domain of MMP14 fusion ligand and human insulin-like growth factor 1 (IGF-1) to the polymer coating of the same IONP. We found that systemic delivery of the targeted and protease active theranostic IONPs led to the accumulation of significant higher levels of the theranostic IONPs into pancreatic tumors, and marked improvement of intratumoral distribution and tumor cell uptake of the nanoparticle-drug carriers in orthotopic human pancreatic cancer tissue derived xenografts (PDX) models in nude mice. Enhanced intratumoral delivery of theranostic nanoparticles could be detected by non-invasive MRI and optical imaging. Multiphoton microscopy showed the ability of the targeted and MMP14 active theranostic nanoparticles penetrating through the stromal barrier that enriched in collagen fibers and entering into the tumor center following intravenous delivery in mice bearing PDX tumors. As the result of improved nanoparticle-drug delivery, systemic administrations of the dual receptor targeted and MMP14 active theranostic IONPs carrying chemotherapy drug, doxorubicin, produced the strongest anti-tumor growth effect compared to single receptor targeted, uPAR-targeted without MMP14 or non-targeted theranostic IONPs in orthotopic pancreatic cancer PDX models in nude mice. Histological analysis revealed that PDX tumors obtained from the mice that received repeated administrations of the dual receptor targeted MMP14-IONPs-Dox had higher levels of tumor cell death and inhibition of cell proliferation compared to those treated with other targeted and non-targeted theranostic IONPs. Therefore, uPAR and IGF-1R dual targeted and MMP14 active theranostic IONPs provide promising nanoparticle-drug delivery carriers for the development of novel targeted and image-guided therapy for applications of precision oncology for effective treatment of pancreatic cancer. Citation Format: Hongyu Zhou, Xiangxue Guo, Weiping Qian, Fatih M. Uckun, Liya Wang, Y Andrew Wang, Hongyu Chen, David A. Kooby, Malgorzata Lipowska, Charles A. Staley, Lily Yang.{Authors}. Stroma breaking dual targeted theranostic nanoparticles for image-guided and targeted therapy of pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr B67.

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/1538-7445.PANCA16-B67

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2016

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

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Re-evaluation of the criteria for asymmetric amplatzer occluders in the closure of perimembranous ventricular septal defects : A case series report

Li, Gang ; Liao, Hongyu ; Wu, Jinlin ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2020

In: Medicine Vol. 99, No. 34 ( 2020-08-21), p. e21356-

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In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 34 ( 2020-08-21), p. e21356-

Type of Medium: Online Resource

ISSN: 0025-7974 , 1536-5964

URL: Article

DOI: 10.1097/MD.0000000000021356

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2020

detail.hit.zdb_id: 2049818-4

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Squeezing excess meso/macropores via self-assembly of zeolitic imidazolate framework units to synthesize dense carbon for high-volume supercapacitors

Bu, Yongfeng ; Jiang, Wenya ; Zhang, Hongyu ; [et al.]

Elsevier BV ; 2023

In: Journal of Power Sources Vol. 563 ( 2023-04), p. 232786-

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In: Journal of Power Sources, Elsevier BV, Vol. 563 ( 2023-04), p. 232786-

Type of Medium: Online Resource

ISSN: 0378-7753

URL: Article

DOI: 10.1016/j.jpowsour.2023.232786

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 1491915-1

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