In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-10-10)
Abstract:
The standard high-flow tracheal (HFT) interface was modified by adding a 5-cm H 2 O/L/s resistor to the expiratory port. First, in a test lung simulating spontaneous breathing, we found that the modified HFT caused an elevation in airway pressure as a power function of flow. Then, three tracheal oxygen treatments (T-piece oxygen at 10 L/min, HFT and modified HFT at 40 L/min) were delivered in a random crossover fashion to six tracheostomized pigs before and after the induction of lung injury. The modified HFT induced a significantly higher airway pressure compared with that in either T-piece or HFT ( p 〈 0.001). Expiratory resistance significantly increased during modified HFT ( p 〈 0.05) to a mean value of 4.9 to 6.7 cm H 2 O/L/s. The modified HFT induced significant augmentation in end-expiratory lung volume ( p 〈 0.05) and improved oxygenation for lung injury model ( p = 0.038) compared with the HFT and T-piece. There was no significant difference in esophageal pressure swings, transpulmonary driving pressure or pressure time product among the three treatments ( p 〉 0.05). In conclusion, the modified HFT with additional expiratory resistance generated a clinically relevant elevation in airway pressure and lung volume. Although expiratory resistance increased, inspiratory effort, lung stress and work of breathing remained within an acceptable range.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-019-51158-0
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2019
detail.hit.zdb_id:
2615211-3
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