In:
Angewandte Chemie, Wiley, Vol. 126, No. 46 ( 2014-11-10), p. 12711-12715
Abstract:
Point‐of‐care testing (POCT) with the advantages of speed, simplicity, portability, and low cost is critical for the measurement of analytes in a variety of environments where access to laboratory infrastructure is lacking. While qualitative POCTs are widely available, quantitative POCTs present significant challenges. Here we describe a novel method that integrates an Au core/Pt shell nanoparticle (Au@PtNP) encapsulated target‐responsive hydrogel with a volumetric bar‐chart chip (V‐Chip) for quantitative POCT. Upon target introduction, the hydrogel immediately dissolves and releases Au@PtNPs, which can efficiently catalyze the decomposition of H 2 O 2 to generate a large volume of O 2 to move of an ink bar in the V‐Chip. The concentration of the target introduced can be visually quantified by reading the traveling distance of the ink bar. This method has the potential to be used for portable and quantitative detection of a wide range of targets without any external instrument.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v126.46
DOI:
10.1002/ange.201405995
Language:
German
Publisher:
Wiley
Publication Date:
2014
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