In:
Diabetes, American Diabetes Association, Vol. 38, No. 10 ( 1989-10-01), p. 1320-1325
Abstract:
Cytoplasmic islet cell antibody–negative (ICA−; & lt;20 Juvenile Diabetes Foundation units, n = 1670) and ICA+ (n = 42) first-degree relatives of type I (insulindependent) diabetic individuals were studied for competitive insulin autoantibodies (ClAAs) with a radioassay. Overall, 3.7% of first-degree relatives (64 of 1712) were CIAA+. Of ICA− relatives, 2.7% (45 of 1670) exceeded the upper limit of our normal CIAA range ( & gt;39 nU/ml), and 45% (19 of 42) of ICA+ relatives exceeded this normal range. Follow-up serums for repeat CIAA determination have been obtained from 16 of the nondiabetic CIAA/ICA individuals (time between samples, 0.4–5.8 yr). Fourteen of these 16 (87%) CIAA/ICA relatives were found to still be positive on follow-up, and 2 of the relatives who were positive on the first determination were negative on their follow-up test. With a mean follow-up of ∼2 yr, 4 of 45 (9%) of the CIAA+/ICA-relatives, 5 of 23 (22%) of the ICA/CIAA-relatives, and 12 of 19 (63%) of the CIAA+/ICA+ relatives developed diabetes. Life-table analysis indicated that, overall, 53% of CIAA+ relatives become diabetic after 5 yr of follow-up versus 65% of ICA+ relatives. Also by life-table analysis, the predicted risk after 5 yr of follow-up for progression to diabetes is 17% for CIAA+/ICA− relatives, 42% for ICA+/CIAA− relatives, and 77% for CIAA/ICA+ relatives. The highest rate of progression to diabetes was found in ICA+ relatives with CIAA levels & gt;150 nU/ml (100% projected to be diabetic within 5 yr, P & lt; .008 vs. ICA/CIAA relatives).
Type of Medium:
Online Resource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.38.10.1320
Language:
English
Publisher:
American Diabetes Association
Publication Date:
1989
detail.hit.zdb_id:
1501252-9
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