In:
Advanced Functional Materials, Wiley, Vol. 28, No. 32 ( 2018-08)
Abstract:
Gd 4 3+ [AlPCS 4 ] 3 4− (AlPCS 4 : aluminium(III) chlorido phthalocyanine tetrasulfonate) inorganic–organic hybrid nanoparticles (IOH‐NPs) are presented as a novel photosensitizer for singlet oxygen ( 1 O 2 ) generation with potential use in localized photodynamic therapy. The saline nanoparticles contain an unprecedented high phthalocyanine content of 81 wt% AlPCS 4 ; they show red emission (680 nm), and efficient 1 O 2 generation. In vitro studies (HepG2 and HeLa cells) demonstrate excellent uptake, low cytotoxicity, and a remarkable induced phototoxicity. Most interestingly, Gd 4 3+ [AlPCS 4 ] 3 4− IOH‐NPs (in suspension) significantly outperform the clinically approved H 4 AlPCS 4 (in solution) in terms of photostability, reactive oxygen species generation, phototoxic effect in cells (i.e., Gd 4 3+ [AlPCS 4 ] 3 4− : LD 50 〈 5 × 10 −6 m ; H 4 AlPCS 4 : LD 50 〉 20 × 10 −6 m , both illuminated 10 min at 670 nm), as well as suppression of microcapillary networks and vascular cord formation. According to in vivo studies, IOH‐NP‐pretreated HeLa‐GFP cells injected into zebrafish larvae can be easily colocalized based on the red emission of the IOH‐NPs and the green emission of the tumor cells. Upon light exposure (0–20 min at 635 nm), the transgenic HeLa‐GFP cells show drastically reduced viability in vivo due to the induced phototoxicity of the Gd 4 3+ [AlPCS 4 ] 3 4− IOH‐NPs.
Type of Medium:
Online Resource
ISSN:
1616-301X
,
1616-3028
DOI:
10.1002/adfm.201801074
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2029061-5
detail.hit.zdb_id:
2039420-2
SSG:
11
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