In:
Journal of the Serbian Chemical Society, National Library of Serbia, , No. 00 ( 2023), p. 63-63
Abstract:
Three Schiff base Cu(II) complexes, (N,N?-bis(acetylacetone)-
propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-
(benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and
(N,N?-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex,
[Cu(tfacac2pn)] (3), were used to investigate the interactions with calf
thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic
absorption and spectroscopic fluorescence methods. UV-Vis absorption studies
showed that studied complexes interact with DNA molecule and exhibit
moderate binding affinity. Fluorescence studies of complexes 1-3 also showed
a possibility for DNA intercalation as well as a relatively high binding
ability toward BSA. Among the tested complexes, the highest affinity for DNA
and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on
human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell
lines, showed that complex 2 exhibited activity on both cell lines, while
complexes 1 and 3 did not show any activity.
Type of Medium:
Online Resource
ISSN:
0352-5139
,
1820-7421
DOI:
10.2298/JSC230614063M
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2023
detail.hit.zdb_id:
2030173-X
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