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From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)

Hartinger, Christian G. ; Zorbas-Seifried, Stefanie ; Jakupec, Michael A. ; [et al.]

Elsevier BV ; 2006

In: Journal of Inorganic Biochemistry Vol. 100, No. 5-6 ( 2006-5), p. 891-904

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In: Journal of Inorganic Biochemistry, Elsevier BV, Vol. 100, No. 5-6 ( 2006-5), p. 891-904

Type of Medium: Online Resource

ISSN: 0162-0134

URL: Article

DOI: 10.1016/j.jinorgbio.2006.02.013

RVK:

VA 5310

Language: English

Publisher: Elsevier BV

Publication Date: 2006

detail.hit.zdb_id: 1491314-8

SSG: 12

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ChemInform Abstract: KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

Hartinger, Christian G. ; Jakupec, Michael A. ; Zorbas-Seifried, Stefanie ; [et al.]

Wiley ; 2009

In: ChemInform Vol. 40, No. 3 ( 2009-01-20)

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In: ChemInform, Wiley, Vol. 40, No. 3 ( 2009-01-20)

Type of Medium: Online Resource

ISSN: 0931-7597 , 1522-2667

URL: Issue

URL: Article

DOI: 10.1002/chin.v40:3

DOI: 10.1002/chin.200903241

Language: English

Publisher: Wiley

Publication Date: 2009

detail.hit.zdb_id: 2110203-X

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DNA Interactions of pH-Sensitive, Antitumor Bis(aminoalcohol)dichloroplatinum(II) Complexes ,

Zorbas-Seifried, Stefanie ; Hartinger, Christian G. ; Meelich, Kristof ; [et al.]

American Chemical Society (ACS) ; 2006

In: Biochemistry Vol. 45, No. 49 ( 2006-12-12), p. 14817-14825

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In: Biochemistry, American Chemical Society (ACS), Vol. 45, No. 49 ( 2006-12-12), p. 14817-14825

Type of Medium: Online Resource

ISSN: 0006-2960 , 1520-4995

URL: Article

DOI: 10.1021/bi061063i

RVK:

WA 15000

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2006

detail.hit.zdb_id: 1472258-6

SSG: 12

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KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

Hartinger, Christian G. ; Jakupec, Michael A. ; Zorbas‐Seifried, Stefanie ; [et al.]

Wiley ; 2008

In: Chemistry & Biodiversity Vol. 5, No. 10 ( 2008-10), p. 2140-2155

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In: Chemistry & Biodiversity, Wiley, Vol. 5, No. 10 ( 2008-10), p. 2140-2155

Abstract: The promising drug candidate indazolium trans ‐[tetrachlorobis(1 H ‐indazole)ruthenate(III)] (KP1019) is the second Ru‐based anticancer agent to enter clinical trials. In this review, which is an update of a paper from 2006 ( Hartinger et al., J. Inorg. Biochem. 2006 , 100 , 891–904), the experimental evidence for the proposed mode of action of this coordination compound is discussed, including transport into the cell via the transferrin cycle and activation by reduction. The results of the early clinical development of KP1019 are summarized in which five out of six evaluated patients experienced disease stabilization with no severe side effects.

Type of Medium: Online Resource

ISSN: 1612-1872 , 1612-1880

URL: Issue

URL: Article

DOI: 10.1002/cbdv.v5:10

DOI: 10.1002/cbdv.200890195

Language: English

Publisher: Wiley

Publication Date: 2008

detail.hit.zdb_id: 2139001-0

SSG: 12

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Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands

Zorbas-Seifried, Stefanie ; Jakupec, Michael A. ; Kukushkin, Nikolay V. ; [et al.]

American Society for Pharmacology & Experimental Therapeutics (ASPET) ; 2007

In: Molecular Pharmacology Vol. 71, No. 1 ( 2007-01), p. 357-365

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In: Molecular Pharmacology, American Society for Pharmacology & Experimental Therapeutics (ASPET), Vol. 71, No. 1 ( 2007-01), p. 357-365

Type of Medium: Online Resource

ISSN: 0026-895X , 1521-0111

URL: Article

DOI: 10.1124/mol.106.030726

Language: English

Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)

Publication Date: 2007

detail.hit.zdb_id: 1475030-2

SSG: 15,3

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The First Ruthenium-Based Paullones: Syntheses, X-ray Diffraction Structures, and Spectroscopic and Antiproliferative Properties in Vitro

Schmid, Wolfgang F. ; Zorbas-Seifried, Stefanie ; John, Roland O. ; [et al.]

American Chemical Society (ACS) ; 2007

In: Inorganic Chemistry Vol. 46, No. 9 ( 2007-04-30), p. 3645-3656

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In: Inorganic Chemistry, American Chemical Society (ACS), Vol. 46, No. 9 ( 2007-04-30), p. 3645-3656

Type of Medium: Online Resource

ISSN: 0020-1669 , 1520-510X

URL: Article

DOI: 10.1021/ic070098j

DOI: 10.1021/ic070098j.s001

DOI: 10.1021/ic070098j.s002

DOI: 10.1021/ic070098j.s003

DOI: 10.1021/ic070098j.s004

DOI: 10.1021/ic070098j.s005

DOI: 10.1021/ic070098j.s006

RVK:

VA 4680

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2007

detail.hit.zdb_id: 7558-9

detail.hit.zdb_id: 1484438-2

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Miniatur-Durchfluß-PCR: ein Durchbruch?

Zorbas, Haralabos

Wiley ; 1999

In: Angewandte Chemie Vol. 111, No. 8 ( 1999-04-19), p. 1121-1124

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In: Angewandte Chemie, Wiley, Vol. 111, No. 8 ( 1999-04-19), p. 1121-1124

Type of Medium: Online Resource

ISSN: 0044-8249 , 1521-3757

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/(SICI)1521-3757(19990419)111:8〈〉1.0.CO;2-0

DOI: 10.1002/(ISSN)1521-3757

DOI: 10.1002/(SICI)1521-3757(19990419)111:8〈1121::AID-ANGE1121〉3.0.CO;2-S

RVK:

VA 2100

RVK:

VN 5020

Language: German

Publisher: Wiley

Publication Date: 1999

detail.hit.zdb_id: 505868-5

detail.hit.zdb_id: 506609-8

detail.hit.zdb_id: 514305-6

detail.hit.zdb_id: 505872-7

detail.hit.zdb_id: 1479266-7

detail.hit.zdb_id: 505867-3

detail.hit.zdb_id: 506259-7

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Hydroxyl radical footprints reveal novel structural features around the NF I binding site in adenovirus DNA

Zorbas, Haralabos ; Rogge, Lars ; Meisterernst, Michael ; [et al.]

Oxford University Press (OUP) ; 1989

In: Nucleic Acids Research Vol. 17, No. 19 ( 1989), p. 7735-7748

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In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 17, No. 19 ( 1989), p. 7735-7748

Type of Medium: Online Resource

ISSN: 0305-1048 , 1362-4962

URL: Article

DOI: 10.1093/nar/17.19.7735

RVK:

WA 15000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 1989

detail.hit.zdb_id: 1472175-2

SSG: 12

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ChemInform Abstract: Miniature Continuous-Flow Polymerase Chain Reaction: A Breakthrough?

Zorbas, Haralabos

Wiley ; 2010

In: ChemInform Vol. 30, No. 29 ( 2010-06-14), p. no-no

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In: ChemInform, Wiley, Vol. 30, No. 29 ( 2010-06-14), p. no-no

Type of Medium: Online Resource

ISSN: 0931-7597 , 1522-2667

URL: Article

DOI: 10.1002/chin.199929314

Language: English

Publisher: Wiley

Publication Date: 2010

detail.hit.zdb_id: 2110203-X

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Absence of an Unusual “Densely Methylated Island” at the Hamster dhfr ori-β

Rein, Theo ; Natale, Darren A. ; Gärtner, Ulrike ; [et al.]

Elsevier BV ; 1997

In: Journal of Biological Chemistry Vol. 272, No. 15 ( 1997-04), p. 10021-10029

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 272, No. 15 ( 1997-04), p. 10021-10029

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.272.15.10021

Language: English

Publisher: Elsevier BV

Publication Date: 1997

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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