In:
Biology of the Cell, Wiley, Vol. 61, No. 1-2 ( 1987-01), p. 51-57
Abstract:
Estramustine, a new anti‐microtubule drug, was added to the culture medium of rabbit mammary explants with lactogenic hormones. In the absence of the drug, prolactin with insulin and cortisol stimulated DNA synthesis and it induced beta‐casein and beta‐casein mRNA accumulation in the tissue. As opposed to other anti‐microtubule agents such as colchicine, estramustine was unable to prevent prolactin actions. An examination of the mammary cells by immunofluorescence revealed that the microtubule network was significantly altered under the influence of estramustine. These data indicate that the integrity of microtubules is not required for prolactin to deliver its message to the mammary cell. These data also suggest that other anti‐microtubule drugs such as colchicine which prevent prolactin action act through their binding to tubulin molecule unrelated to microtubule structures.
Type of Medium:
Online Resource
ISSN:
0248-4900
,
1768-322X
DOI:
10.1111/boc.1987.61.issue-1-2
DOI:
10.1111/j.1768-322X.1987.tb00568.x
Language:
English
Publisher:
Wiley
Publication Date:
1987
detail.hit.zdb_id:
2011750-4
SSG:
12
Bookmarklink