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Correction: Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Ahuja, Shama D. ; Ashkin, David ; Avendano, Monika ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS Medicine Vol. 9, No. 9 ( 2012-9-14)

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In: PLoS Medicine, Public Library of Science (PLoS), Vol. 9, No. 9 ( 2012-9-14)

Type of Medium: Online Resource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/annotation/230240bc-bcf3-46b2-9b21-2e6e584f7333

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2164823-2

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Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Ahuja, Shama D. ; Ashkin, David ; Avendano, Monika ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS Medicine Vol. 9, No. 8 ( 2012-8-28), p. e1001300-

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In: PLoS Medicine, Public Library of Science (PLoS), Vol. 9, No. 8 ( 2012-8-28), p. e1001300-

Type of Medium: Online Resource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/journal.pmed.1001300

DOI: 10.1371/journal.pmed.1001300.s001

DOI: 10.1371/journal.pmed.1001300.s002

DOI: 10.1371/journal.pmed.1001300.s003

DOI: 10.1371/journal.pmed.1001300.s004

DOI: 10.1371/journal.pmed.1001300.s005

DOI: 10.1371/journal.pmed.1001300.s006

DOI: 10.1371/journal.pmed.1001300.s007

DOI: 10.1371/journal.pmed.1001300.s008

DOI: 10.1371/journal.pmed.1001300.s009

DOI: 10.1371/journal.pmed.1001300.s010

DOI: 10.1371/journal.pmed.1001300.s011

DOI: 10.1371/journal.pmed.1001300.s012

DOI: 10.1371/journal.pmed.1001300.s013

DOI: 10.1371/journal.pmed.1001300.s014

DOI: 10.1371/journal.pmed.1001300.s015

DOI: 10.1371/journal.pmed.1001300.s016

DOI: 10.1371/journal.pmed.1001300.s017

DOI: 10.1371/journal.pmed.1001300.s018

DOI: 10.1371/journal.pmed.1001300.s019

DOI: 10.1371/journal.pmed.1001300.s020

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2164823-2

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Pharmacokinetic Modeling and Optimal Sampling Strategies for Therapeutic Drug Monitoring of Rifampin in Patients with Tuberculosis

Sturkenboom, Marieke G. G. ; Mulder, Leonie W. ; de Jager, Arthur ; [et al.]

American Society for Microbiology ; 2015

In: Antimicrobial Agents and Chemotherapy Vol. 59, No. 8 ( 2015-08), p. 4907-4913

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In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 59, No. 8 ( 2015-08), p. 4907-4913

Abstract: Rifampin, together with isoniazid, has been the backbone of the current first-line treatment of tuberculosis (TB). The ratio of the area under the concentration-time curve from 0 to 24 h (AUC 0–24 ) to the MIC is the best predictive pharmacokinetic-pharmacodynamic parameter for determinations of efficacy. The objective of this study was to develop an optimal sampling procedure based on population pharmacokinetics to predict AUC 0–24 values. Patients received rifampin orally once daily as part of their anti-TB treatment. A one-compartmental pharmacokinetic population model with first-order absorption and lag time was developed using observed rifampin plasma concentrations from 55 patients. The population pharmacokinetic model was developed using an iterative two-stage Bayesian procedure and was cross-validated. Optimal sampling strategies were calculated using Monte Carlo simulation ( n = 1,000). The geometric mean AUC 0–24 value was 41.5 (range, 13.5 to 117) mg · h/liter. The median time to maximum concentration of drug in serum ( T max ) was 2.2 h, ranging from 0.4 to 5.7 h. This wide range indicates that obtaining a concentration level at 2 h ( C 2 ) would not capture the peak concentration in a large proportion of the population. Optimal sampling using concentrations at 1, 3, and 8 h postdosing was considered clinically suitable with an r 2 value of 0.96, a root mean squared error value of 13.2%, and a prediction bias value of −0.4%. This study showed that the rifampin AUC 0–24 in TB patients can be predicted with acceptable accuracy and precision using the developed population pharmacokinetic model with optimal sampling at time points 1, 3, and 8 h.

Type of Medium: Online Resource

ISSN: 0066-4804 , 1098-6596

URL: Article

DOI: 10.1128/AAC.00756-15

RVK:

XA 24552

Language: English

Publisher: American Society for Microbiology

Publication Date: 2015

detail.hit.zdb_id: 1496156-8

SSG: 12

SSG: 15,3

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Corticosteroid therapy for the management of paradoxical inflammatory reaction in patients with pulmonary tuberculosis

Done, Macky M. ; Akkerman, Onno W. ; Al-Kailany, Wud ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Infection Vol. 48, No. 4 ( 2020-08), p. 641-645

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In: Infection, Springer Science and Business Media LLC, Vol. 48, No. 4 ( 2020-08), p. 641-645

Abstract: Paradoxical reaction after the initiation of tuberculosis treatment is defined as increased inflammation following effective antimycobacterial treatment. This is a phenomenon that can severely complicate a patient’s recovery, potentially leading to further morbidity and residual deficits. Paradoxical reaction remains poorly understood regarding its pathophysiology and management. Only a limited number of reports look critically at the available therapeutic options, with evidence of the efficacy of prednisolone therapy being primarily limited to extrapulmonary PR only. Case We describe two HIV negative patients who were admitted to our department with pulmonary tuberculosis, presenting with inflammatory patterns attributable to PR and their response to adjunctive steroid therapy. Discussion and Conclusions The presented cases further highlight the need for immunological studies and randomized trials for corticosteroid therapy are needed to better understand this phenomenon as well as provide an evidence-base for anti-inflammatory treatment. Furthermore, by means of this case series, we are also able to highlight the potential variability in the symptomatology of the lesser known PR phenomenon, in which we observed a hypotensive shock-like syndrome not previously described in literature.

Type of Medium: Online Resource

ISSN: 0300-8126 , 1439-0973

URL: Article

DOI: 10.1007/s15010-020-01430-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2006315-5

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Clinical Relevance of Mycobacterium szulgai in The Netherlands

van Ingen, Jakko ; Boeree, Martin J. ; de Lange, Wiel C. M. ; [et al.]

Oxford University Press (OUP) ; 2008

In: Clinical Infectious Diseases Vol. 46, No. 8 ( 2008-04-15), p. 1200-1205

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In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 46, No. 8 ( 2008-04-15), p. 1200-1205

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Issue

URL: Article

DOI: 10.1086/588450

DOI: 10.1086/529443

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2008

detail.hit.zdb_id: 2002229-3

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Clinical Relevance of Rifampicin‐Moxifloxacin Interaction in Isoniazid-Resistant/Intolerant Tuberculosis Patients

Vogensen, Vanessa B. ; Bolhuis, Mathieu S. ; Sturkenboom, Marieke G. G. ; [et al.]

American Society for Microbiology ; 2022

In: Antimicrobial Agents and Chemotherapy Vol. 66, No. 2 ( 2022-02-15)

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In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 66, No. 2 ( 2022-02-15)

Abstract: Moxifloxacin is an attractive drug for the treatment of isoniazid-resistant rifampicin-susceptible tuberculosis (TB) or drug-susceptible TB complicated by isoniazid intolerance. However, co-administration with rifampicin decreases moxifloxacin exposure. It remains unclear whether this drug–drug interaction has clinical implications. This retrospective study in a Dutch TB center investigated how rifampicin affected moxifloxacin exposure in patients with isoniazid-resistant or -intolerant TB. Moxifloxacin exposures were measured between 2015 and 2020 in 31 patients with isoniazid-resistant or -intolerant TB receiving rifampicin, and 20 TB patients receiving moxifloxacin without rifampicin. Moxifloxacin exposure, i.e., area under the concentration-time curve (AUC 0-24h ), and attainment of AUC 0-24h /MIC 〉 100 were investigated for 400 mg moxifloxacin and 600 mg rifampicin, and increased doses of moxifloxacin (600 mg) or rifampicin (900 mg). Moxifloxacin AUC 0–24h and peak concentration with a 400 mg dose were decreased when rifampicin was co-administered compared to moxifloxacin alone (ratio of geometric means 0.61 (90% CI (0.53, 0.70) and 0.81 (90% CI (0.70, 0.94), respectively). Among patients receiving rifampicin, 65% attained an AUC 0-24h /MIC 〉 100 for moxifloxacin compared to 78% of patients receiving moxifloxacin alone; this difference was not significant. Seven out of eight patients receiving an increased dose of 600 mg moxifloxacin reached the target AUC 0-24h /MIC 〉 100. This study showed a clinically significant 39% decrease in moxifloxacin exposure when rifampicin was co-administered. Moxifloxacin dose adjustment may compensate for this drug–drug interaction. Further exploring the impact of higher doses of these drugs in patients with isoniazid resistance or intolerance is paramount.

Type of Medium: Online Resource

ISSN: 0066-4804 , 1098-6596

URL: Article

DOI: 10.1128/aac.01829-21

RVK:

XA 24552

Language: English

Publisher: American Society for Microbiology

Publication Date: 2022

detail.hit.zdb_id: 1496156-8

SSG: 12

SSG: 15,3

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Malnutrition assessment methods in adult patients with tuberculosis: a systematic review

ter Beek, Lies ; Bolhuis, Mathieu S ; Jager-Wittenaar, Harriët ; [et al.]

BMJ ; 2021

In: BMJ Open Vol. 11, No. 12 ( 2021-12), p. e049777-

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In: BMJ Open, BMJ, Vol. 11, No. 12 ( 2021-12), p. e049777-

Abstract: Malnutrition is associated with a twofold higher risk of dying in patients with tuberculosis (TB) and considered an important potentially reversible risk factor for failure of TB treatment. The construct of malnutrition has three domains: intake or uptake of nutrition; body composition and physical and cognitive function. The objectives of this systematic review are to identify malnutrition assessment methods, and to quantify how malnutrition assessment methods capture the international consensus definition for malnutrition, in patients with TB. Design Different assessment methods were identified. We determined the extent of capturing of the three domains of malnutrition, that is, intake or uptake of nutrition, body composition and physical and cognitive function. Results Seventeen malnutrition assessment methods were identified in 69 included studies. In 53/69 (77%) of studies, body mass index was used as the only malnutrition assessment method. Three out of 69 studies (4%) used a method that captured all three domains of malnutrition. Conclusions Our study focused on published articles. Implementation of new criteria takes time, which may take longer than the period covered by this review. Most patients with TB are assessed for only one aspect of the conceptual definition of malnutrition. The use of international consensus criteria is recommended to establish uniform diagnostics and treatment of malnutrition. PROSPERO registration number CRD42019122832.

Type of Medium: Online Resource

ISSN: 2044-6055 , 2044-6055

URL: Article

DOI: 10.1136/bmjopen-2021-049777

Language: English

Publisher: BMJ

Publication Date: 2021

detail.hit.zdb_id: 2599832-8

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Therapeutic drug monitoring of first-line anti-tuberculosis drugs comprises more than C〈SUB〉2h〈/SUB〉 measurements

Sturkenboom, Marieke G. G. ; Bolhuis, Mathieu S. ; Akkerman, Onno W. ; [et al.]

International Union Against Tuberculosis and Lung Disease ; 2016

In: The International Journal of Tuberculosis and Lung Disease Vol. 20, No. 12 ( 2016-12-01), p. 1695-1696

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In: The International Journal of Tuberculosis and Lung Disease, International Union Against Tuberculosis and Lung Disease, Vol. 20, No. 12 ( 2016-12-01), p. 1695-1696

Type of Medium: Online Resource

ISSN: 1027-3719 , 1815-7920

URL: Article

DOI: 10.5588/ijtld.16.0550

Language: English

Publisher: International Union Against Tuberculosis and Lung Disease

Publication Date: 2016

detail.hit.zdb_id: 2168620-8

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Pharmacokinetic/pharmacodynamic-based optimization of levofloxacin administration in the treatment of MDR-TB

Ghimire, Samiksha ; van't Boveneind-Vrubleuskaya, Natasha ; Akkerman, Onno W. ; [et al.]

Oxford University Press (OUP) ; 2016

In: Journal of Antimicrobial Chemotherapy Vol. 71, No. 10 ( 2016-10), p. 2691-2703

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In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 71, No. 10 ( 2016-10), p. 2691-2703

Type of Medium: Online Resource

ISSN: 0305-7453 , 1460-2091

URL: Article

DOI: 10.1093/jac/dkw164

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2016

detail.hit.zdb_id: 1467478-6

SSG: 15,3

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Different Underlying Mechanism Might Explain the Absence of a Significant Difference in Area Under the Concentration–Time Curve of Linezolid for Different ABCB1 Genotypes

Bolhuis, Mathieu S. ; Akkerman, Onno W. ; Sturkenboom, Marieke G. G. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2019

In: Therapeutic Drug Monitoring Vol. 41, No. 2 ( 2019-04), p. 253-254

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In: Therapeutic Drug Monitoring, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 2 ( 2019-04), p. 253-254

Type of Medium: Online Resource

ISSN: 0163-4356

URL: Article

DOI: 10.1097/FTD.0000000000000597

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2019

detail.hit.zdb_id: 2048919-5

SSG: 15,3

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