In:
Journal of Applied Toxicology, Wiley, Vol. 35, No. 7 ( 2015-07), p. 831-841
Abstract:
Genomic biomarkers for direct immunotoxicity that were previously identified in human Jurkat T cells were tested using new compounds and compound classes. RNA isolated from exposures of Jurkat cells with subcytotoxic concentrations of compounds were subjected to Fluidigm high throughput analysis. The sensitivity (100%), specificity (80%) and accuracy (93%) were all higher than before. This Jurkat screening assay holds great promise to be applied in an animal‐free testing strategy for human immunotoxicity.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475015-6
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