In:
European Journal of Clinical Investigation, Wiley, Vol. 47, No. 4 ( 2017-04), p. 289-296
Kurzfassung:
The binding of apolipoprotein (apo) B‐containing lipoproteins to circulating erythrocytes (ery‐apoB) is associated with a decreased prevalence of atherosclerosis. In this study, we evaluated ery‐apoB as a possible prognostic factor in cardiovascular events and all‐cause mortality, in a prospective cohort study. Materials and methods Ery‐apoB was measured by flow cytometry in subjects with and without cardiovascular disease ( CVD ). The primary endpoint was the cardiovascular event rate. Secondary endpoints were all‐cause mortality and the combined endpoint of all‐cause mortality and cardiovascular events (any event rate). A Cox regression analysis with univariate and multivariate analyses and Kaplan–Meier survival analysis was performed. Results Follow‐up data were available of 384 subjects. Subjects were divided according to high ( 〉 2·0 au, n = 60), intermediate (0·2–2·0 au, n = 274) or low ( 〈 0·2 au, n = 50) ery‐apoB. Median follow‐up was 1767 days ( IQR 1564–2001). In univariate analysis, low ery‐apoB was associated with increased all‐cause mortality [ HR 9·9 (1·2–79·0), P = 0·031] and any event rate [ HR 3·4 (95% CI 1·3–8·7), P = 0·012]. In a Cox regression analysis, only a history of CVD was significantly associated with any event rate [ HR 3·6 (1·6–8·0), P = 0·002], while low ery‐apoB showed a trend [ HR 2·4 (0·9–6·4), P = 0·07]. In a subgroup analysis, in subjects with a history of CVD , ery‐apoB was significantly associated with all‐cause mortality (log rank P = 0·021) and any event rate (log rank P = 0·009). Conclusions Low ery‐apoB is associated with increased mortality and cardiovascular risk, especially in patients with a prior history of CVD . These subjects may benefit from more aggressive secondary prevention treatment.
Materialart:
Online-Ressource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2017.47.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
2004971-7
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