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  • 1
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    A case series of canine cutaneous inverted papilloma with one case showing evidence of recurrence
    Wiley ; 2021
    In:  Veterinary Dermatology Vol. 32, No. 3 ( 2021-06), p. 268-
    Details
    In: Veterinary Dermatology, Wiley, Vol. 32, No. 3 ( 2021-06), p. 268-
    Abstract: Este artigo descreve um caso de papilomas cutâneos invertidos (PCIs) múltiplos e recorrentes em um cão pastor alemão, combinado com uma avaliação de acompanhamento retrospectivo de oito casos. Métodos Uma cadela pastor alemão de 3 anos de idade, preta, apresentou quatro nódulos alopécicos, abaulados, hiperpigmentados e brilhantes de crescimento rápido, compatíveis com PCI. O cão foi tratado para prurido associado a dermatite atópica com prednisolona a longo prazo e esta terapia foi continuada após a excisão cirúrgica. Doze meses após a apresentação inicial, o cão foi apresentado por duas novas lesões PCI, coincidindo com um aumento da dosagem de prednisolona durante um período de crise alérgica. Resultados A avaliação histopatológica foi realizada nas lesões originais e subsequentes do caso com recidiva. Oito casos de PCI foram identificados retrospectivamente com base em achados histopatológicos do serviço de patologia diagnóstica dos autores nos últimos dois anos. Todos os nove casos tinham lesões que exibiam vários graus de hiperplasia epitelial invertida, múltiplas projeções epidérmicas papilares endofíticas, uma base em forma de copo com hiperceratose central e achados patológicos virais ativos (coilócitos). Os veterinários foram contatados e o acompanhamento com relação à recorrência e medicamentos simultâneos foi obtido. Conclusões e importância clínica A PCI é raramente relatada, geralmente como uma lesão única sem relatos anteriores de recorrência, embora um grupo de cães com imunodeficiência combinada grave tenha desenvolvido malignidades invasivas. Em sete dos oito casos retrospectivos, nenhuma recorrência de PCI foi registrada. Os autores especulam que a recorrência no cão pastor alemão pode ter sido associada à administração crônica (embora em baixa dosagem) de glicocorticoides.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    URL: Article
    DOI: 10.1111/vde.v32.3
    DOI: 10.1111/vde.12961
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 2
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    Cutaneous microRNA expression in healthy Labrador and Golden retrievers and retrievers with allergic and inflammatory skin diseases
    Wiley ; 2021
    In:  Veterinary Dermatology Vol. 32, No. 4 ( 2021-08), p. 331-
    Details
    In: Veterinary Dermatology, Wiley, Vol. 32, No. 4 ( 2021-08), p. 331-
    Abstract: Background – MicroRNAs (miRNA) are short, single‐stranded RNA molecules that regulate gene expression in a post‐transcriptional manner. Their expression is proposed to be tissue‐specific and alterations in miRNA expression have been detected in many diseases. Objective – To compare miRNA expression in the skin of healthy Labrador and golden retrievers, and those with allergic and nonallergic dermatitis. Conclusion and clinical relevance – Although the number of included dogs was small, based on this study, none of the evaluated miRNAs allowed differentiation of allergic dermatitis from other inflammatory skin diseases in retriever dogs.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    URL: Article
    DOI: 10.1111/vde.v32.4
    DOI: 10.1111/vde.12971
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 3
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    Artificial Intelligence to Predict the BRAF V595E Mutation in Canine Urinary Bladder Urothelial Carcinomas
    MDPI AG ; 2023
    In:  Animals Vol. 13, No. 15 ( 2023-07-25), p. 2404-
    Details
    In: Animals, MDPI AG, Vol. 13, No. 15 ( 2023-07-25), p. 2404-
    Abstract: In dogs, the BRAF mutation (V595E) is common in bladder and prostate cancer and represents a specific diagnostic marker. Recent advantages in artificial intelligence (AI) offer new opportunities in the field of tumour marker detection. While AI histology studies have been conducted in humans to detect BRAF mutation in cancer, comparable studies in animals are lacking. In this study, we used commercially available AI histology software to predict BRAF mutation in whole slide images (WSI) of bladder urothelial carcinomas (UC) stained with haematoxylin and eosin (HE), based on a training (n = 81) and a validation set (n = 96). Among 96 WSI, 57 showed identical PCR and AI-based BRAF predictions, resulting in a sensitivity of 58% and a specificity of 63%. The sensitivity increased substantially to 89% when excluding small or poor-quality tissue sections. Test reliability depended on tumour differentiation (p 〈 0.01), presence of inflammation (p 〈 0.01), slide quality (p 〈 0.02) and sample size (p 〈 0.02). Based on a small subset of cases with available adjacent non-neoplastic urothelium, AI was able to distinguish malignant from benign epithelium. This is the first study to demonstrate the use of AI histology to predict BRAF mutation status in canine UC. Despite certain limitations, the results highlight the potential of AI in predicting molecular alterations in routine tissue sections.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani13152404
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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  • 4
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    Black hair follicular dysplasia in Large Münsterländer dogs: clinical, histological and ultrastructural features
    Wiley ; 2006
    In:  Veterinary Dermatology Vol. 17, No. 3 ( 2006-06), p. 182-188
    Details
    In: Veterinary Dermatology, Wiley, Vol. 17, No. 3 ( 2006-06), p. 182-188
    Abstract: Four Large Münsterländer cross‐bred dogs affected with black hair follicular dysplasia (BHFD) and one unaffected control littermate were observed, and skin was sampled weekly over the first 19 weeks of life. Affected dogs were born with silvery grey hair, a consequence of melanin clumping in the hair shafts. Hair bulb melanocytes were densely pigmented, and contained abundant stage IV melanosomes but adjacent matrix keratinocytes lacked melanosomes. Melanin clumping was not prominent in epidermal melanocytes in the haired skin but occurred in the foot pads. Follicular changes progressed from bulbar clumping, clumping in the isthmus/infundibulum and finally to dysplastic hair shafts. Alopecia developed progressively in pigmented areas. Silver‐grey hair, melanin clumping, accumulation of stage IV melanosomes within melanocytes and insufficient melanin transfer to adjacent keratinocytes are also classic features of human Griscelli syndrome. The underlying cause in Griscelli syndrome is a defect of melanocytic intracellular transport proteins leading to inadequate and disorganized melanosome transfer to keratinocytes with resultant melanin clumping. In view of the correlation in the phenotype, histology and ultrastructure between both disorders, a defect in intracellular melanosome transport is postulated as the pathogenic mechanism in BHFD.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    URL: Article
    DOI: 10.1111/vde.2006.17.issue-3
    DOI: 10.1111/j.1365-3164.2006.00517.x
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 5
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    Sebaceous adenitis and mural folliculitis in a cat responsive to topical fatty acid supplementation
    Wiley ; 2016
    In:  Veterinary Dermatology Vol. 27, No. 1 ( 2016-02), p. 57-
    Details
    In: Veterinary Dermatology, Wiley, Vol. 27, No. 1 ( 2016-02), p. 57-
    Abstract: image
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    URL: Article
    DOI: 10.1111/vde.2016.27.issue-1
    DOI: 10.1111/vde.12282
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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  • 6
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    Animal Histoplasmosis in Europe: Review of the Literature and Molecular Typing of the Etiological Agents
    MDPI AG ; 2022
    In:  Journal of Fungi Vol. 8, No. 8 ( 2022-08-09), p. 833-
    Details
    In: Journal of Fungi, MDPI AG, Vol. 8, No. 8 ( 2022-08-09), p. 833-
    Abstract: Histoplasmosis has been previously diagnosed in animals from Europe. The aim of this study is to review the literature on these reports, to analyze cases diagnosed at our laboratory (2000–2022) and to improve molecular typing of Histoplasma capsulatum directly from tissue to study the molecular epidemiology of Histoplasma capsulatum causing animal infections in Europe. Including 15 cases studied in our laboratory, we identified 39 cases of animal histoplasmosis between 1968 and 2022. They were diagnosed mostly in superficial tissue biopsies from cats and badgers from Central Europe. Using phylogenetic analyses of six partial genes, we were able to classify eight of the etiological agents as belonging to a highly supported lineage within the Eurasian clade. This study confirms the occurrence of autochthonous histoplasmosis in animals in Central Europe and proposes the addition of new loci to the MLST scheme to study the molecular epidemiology of histoplasmosis using either formalin-fixed paraffin-embedded tissue and fresh or cadaveric biopsies.
    Type of Medium: Online Resource
    ISSN: 2309-608X
    URL: Article
    DOI: 10.3390/jof8080833
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2784229-0
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  • 7
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    BRAF mutation status and its prognostic significance in 79 canine urothelial carcinomas: A retrospective study (2006–2019)
    Wiley ; 2022
    In:  Veterinary and Comparative Oncology Vol. 20, No. 2 ( 2022-06), p. 449-457
    Details
    In: Veterinary and Comparative Oncology, Wiley, Vol. 20, No. 2 ( 2022-06), p. 449-457
    Abstract: Urothelial carcinoma (UC) is the most common tumour of the canine urinary bladder. Recently, BRAF mutation testing emerged as a diagnostic option, but its prognostic significance is unknown. This study investigates the relationship between BRAF (variant V595E) mutation status and overall survival in UC‐bearing dogs. Seventy‐nine patients histologically diagnosed with UC of the bladder and/or urethra between 2006 and 2019 were included in this retrospective single‐centre‐study. Treatment consisted of meloxicam ( n  = 39, group 1 ‘Melox’), mitoxantrone and meloxicam (+/− followed by metronomic chlorambucil; n  = 23, group 2 ‘Chemo’) or partial cystectomy followed by meloxicam +/− mitoxantrone ( n  = 17, group 3 ‘Sx’). Survival was significantly influenced by treatment ( p  = .0002) and tumour location ( p   〈  .001) in both uni‐ and multivariable analyses. BRAF mutation was identified in 51 tumours (=64.6%) and had no statistically significant influence on overall survival: MST for BRAF‐negative patients 359 versus 214 days for BRAF‐positive dogs ( p  = .055). However, in BRAF‐positive dogs, survival depended significantly on type of treatment in univariable analysis: MSTs for groups 1–3 were 151, 244 and 853 days, respectively ( p  = .006); In BRAF‐positive group 2 (‘Chemo’)‐patients, adjuvant metronomic chlorambucil after mitoxantrone more than doubled MST compared to patients receiving mitoxantrone alone (588 vs. 216 days; p  = .030). In contrast, MSTs were not significantly different in BRAF‐negative patients among the three treatment groups ( p  = .069). Multivariate analysis of these data was not possible due to group size limitations. This study identified tumour location and treatment type, but not BRAF mutation status, as independent prognostic factors for overall survival.
    Type of Medium: Online Resource
    ISSN: 1476-5810 , 1476-5829
    URL: Issue
    URL: Article
    DOI: 10.1111/vco.v20.2
    DOI: 10.1111/vco.12790
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2129634-0
    SSG: 22
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  • 8
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    Renal Nephroblastoma in a 17-Month-Old Jack Russell Terrier
    American Animal Hospital Association ; 2019
    In:  Journal of the American Animal Hospital Association Vol. 55, No. 5 ( 2019-09-01)
    Details
    In: Journal of the American Animal Hospital Association, American Animal Hospital Association, Vol. 55, No. 5 ( 2019-09-01)
    Abstract: A 17 mo old female Jack Russell terrier was diagnosed with unilateral primary malignant nephroblastoma. The dog presented with polyuria and polydipsia. Laboratory tests revealed polycythemia and elevated serum erythropoietin levels. Diagnostic imaging (i.e., MRI) revealed a unilateral renal mass without spinal cord involvement. Nephrectomy was performed, and the histopathologic diagnosis was nephroblastoma. The dog did not receive any chemotherapy, and there was no evidence of recurrent disease or metastasis over 30 mo after nephrectomy. This is the first case report of a dog presenting with polyuria and polydipsia found to be a result of nephroblastoma. Furthermore, this is the longest survival reported for canine nephroblastoma treated with nephrectomy alone.
    Type of Medium: Online Resource
    ISSN: 0587-2871 , 1547-3317
    URL: Article
    DOI: 10.5326/JAAHA-MS-6664
    Language: English
    Publisher: American Animal Hospital Association
    Publication Date: 2019
    SSG: 22
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  • 9
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    Detection of novel chlamydiae in cats with ocular disease
    American Veterinary Medical Association (AVMA) ; 2003
    In:  American Journal of Veterinary Research Vol. 64, No. 11 ( 2003-11-01), p. 1421-1428
    Details
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 64, No. 11 ( 2003-11-01), p. 1421-1428
    Abstract: Objective —To detect and characterize the full range of chlamydial infections in cats with ocular disease by use of polymerase chain reaction (PCR) assays, cytologic examination, immunohistochemical analysis, and evaluation of clinical information including status for feline herpesvirus-1 (FeHV-1). Sample Population —DNA extracted from 226 conjunctival samples obtained from cats with clinically diagnosed keratitis or conjunctivitis and 30 conjunctival samples from healthy cats. Procedure —PCR assays for the 16S rRNA gene specific for the order Chlamydiales and a new Chlamydophila felis (formerly Chlamydia psittaci ) species-specific 23S rRNA gene were performed. Seventy-four conjunctival samples were prepared with Romanowsky-type stain, grouped on the basis of inflammatory pattern, and screened for chlamydial inclusions by use of immunohistochemical analysis. Clinical information and FeHV-1 status were recorded. Results —26 (12%) specimens had positive results for the only known feline chlamydial pathogen, C felis . Surprisingly, an additional 88 (39%) were positive for non- C felis chlamydial DNA. Identification of non- C felis chlamydial DNA by direct sequencing revealed 16S rRNA gene sequences that were 99% homologous to the sequence for Neochlamydia hartmannellae , an amebic endosymbiont. Chlamydial prevalence was significantly higher in cats with ocular disease. Conclusions and Clinical Relevance —Application of a broad-range detection method resulted in identification of a new agent associated with ocular disease in cats. Finding chlamydia-like agents such as N hartmannellae in coinfections with their obligate amebic host, Hartmannella vermiformis , raises questions about the potential role of these microorganisms in causation or exacerbation of ocular disease in cats. ( Am J Vet Res 2003;64:1421–1428)
    Type of Medium: Online Resource
    ISSN: 0002-9645
    URL: Article
    DOI: 10.2460/ajvr.2003.64.1421
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2003
    detail.hit.zdb_id: 2056942-7
    SSG: 22
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  • 10
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    Subcutaneous extraskeletal osteosarcoma in a metatarsal footpad in a cat
    Wiley ; 2017
    In:  Veterinary Dermatology Vol. 28, No. 5 ( 2017-10), p. 524-
    Details
    In: Veterinary Dermatology, Wiley, Vol. 28, No. 5 ( 2017-10), p. 524-
    Abstract: Osteossarcomas extra‐esqueléticos ( OSAE s) são neoplasias raras em humanos e em cães. Em relatos de gatos, OSAE s originam‐se das regiões ocular, orbital, intestinal, mamária e subcutânea. Os OSAE s subcutâneos ocorrem mais comumente em locais utilizados para vacinação, incluindo as regiões intraescapular, dorsolombar e nas coxas. Os relatos de casos anteriores em felinos não documentaram o uso de técnicas avançadas de diagnóstico por imagem para excluir um tumor ósseo primário. Objetivo Descrever os achados clinicopatológicos e de diagnóstico por imagem avançado de um OSAE subcutâneo em um coxim metatarsal de um felino e relatar o acompanhamento do caso por um ano. Animal Um felino doméstico de pelo curto, macho, castrado, de nove anos de idade. Métodos Realização de exame físico e avaliação por tomografia computadorizada, ultrassonografia abdominal, histopatológico de biópsia excisional e imunohistoquímica. Resultados O gato foi apresentado com uma área de eritema discreto e aumento de volume no coxim metatarsal direito, no qual foi diagnosticado um OSAE a partir de exames de imagem avançados e histopatologia. Os achados histopatológicos foram consistentes com osteossarcoma. Não foi observada doença óssea primária na tomografia computadorizada. Os proprietários optaram por realizar a amputação do membro. Um ano após o diagnóstico, o gato estava vivo e sem sinais de progressão da doença. Conclusões e importância clínica O osteossarcoma extra‐esquelético deve ser considerado um diagnóstico diferencial de aumentos de volume de tecido mole em coxins de felinos. As técnicas de diagnóstico por imagem avançadas são recomendadas para excluir tumores ósseos primários.
    Type of Medium: Online Resource
    ISSN: 0959-4493 , 1365-3164
    URL: Issue
    URL: Article
    DOI: 10.1111/vde.2017.28.issue-5
    DOI: 10.1111/vde.12461
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2011122-8
    SSG: 22
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