Umfang:
Online-Ressource
ISSN:
2699-9307
Inhalt:
Cells sense extracellular matrix‐induced biophysical signals, which are transduced into intracellular signaling cascades, and trigger a series of cell responses, including adhesion, migration, and lineage commitment. Traditionally, in in vitro context, monofactorial approaches are employed to control cell fate, despite the fact that in vivo cells are exposed simultaneously to a diverse range of signals. Herein, an overview of key mechanotransduction pathways is first provided. Conventional single‐factor and contemporary multifactorial methodologies, based on substrate rigidity and surface topography, are then reviewed to recapitulate in vitro the in vivo niche, in an attempt to elucidate the underlying mechanisms involved in human mesenchymal stromal cell‐material interactions.
In:
day:03
In:
month:12
In:
year:2023
In:
extent:15
In:
Advanced nanoBiomed research, Weinheim : Wiley-VCH, [2021]-, (03.12.2023) (gesamt 15), 2699-9307
Sprache:
Englisch
DOI:
10.1002/anbr.202300042
URN:
urn:nbn:de:101:1-2023120414205865052235
URL:
https://doi.org/10.1002/anbr.202300042
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023120414205865052235
URL:
https://d-nb.info/1312102977/34
URL:
https://doi.org/10.1002/anbr.202300042
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