Format:
Online-Ressource (258 p.)
Edition:
Online-Ausg. 2011 Electronic reproduction; Available via World Wide Web
ISBN:
9780470503485
,
0470503483
,
1283453932
,
9780470503485
,
9781283453936
Content:
The rapid increase of the power of personal computers has led to the use of serious simulation programs such as easy POP in genetic studies. This book summarizes recent advances in forward-time simulation methods and demonstrates their applications in population genetics and genetic epidemiology. The authors introduce commonly used forward-time population genetics simulation methods, including some new methods, and introduce a forward-time population genetics simulation environment, simuPOP, as a powerful and flexible tool to implement these simulations. Researchers and students in population and statistical genetics will find this book useful
Content:
The only book available in the area of forward-time population genetics simulations-applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introduces simuPOP, a powerful and flexible new program that can be used to simulate arbitrary evolutionary processes with unique features like customized chromosome types, arbitrary nonrandom mating schemes, virtual subpopulation
Note:
Description based upon print version of record
,
FORWARD-TIME POPULATION GENETICS SIMULATIONS: Methods, Implementation, and Applications; CONTENTS; PREFACE; ACKNOWLEDGMENTS; LIST OF EXAMPLES; 1 BASIC CONCEPTS AND MODELS; 1.1 Biological and Genetic Concepts; 1.1.1 Genome and Chromosomes; 1.1.2 Genes, Markers, Loci, and Alleles; 1.1.3 Recombination and Linkage; 1.1.4 Sex Chromosomes; 1.1.5 Mutation and Mutation Models; 1.2 Population and Evolutionary Genetics; 1.2.1 Population Variation and Mutation; 1.2.2 The Wright-Fisher Model and Random Mating; 1.2.3 The Hardy-Weinberg Equilibrium; 1.2.4 Genetic Drift and Effective Population Size
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1.2.5 Natural Selection1.2.6 Linkage Equilibrium; 1.2.7 Population Structure and Migration; 1.2.8 Demographic History of Human Populations; 1.2.9 Coalescent and Backward-Time Simulations; 1.2.10 Forward-Time Simulations; 1.3 Statistical Genetics and Genetic Epidemiology; 1.3.1 Penetrance Models; 1.3.2 Simple and Complex Genetic Diseases; 1.3.3 Phenotypic, Allelic, and Locus Heterogeneity; 1.3.4 Study Designs of Gene Mapping; References; 2 SIMULATION OF POPULATION GENETICS MODELS; 2.1 Random Genetic Drift; 2.1.1 Dynamics of Allele Frequency and Heterozygosity; 2.1.2 Persistence Time
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2.2 Demographic Models2.2.1 The Bottleneck Effect; 2.3 Mutation; 2.3.1 A Diallelic Mutation Model; 2.3.2 Multiallelic Mutation Models; 2.4 Migration; 2.4.1 An Island Model of Migration; 2.5 Recombination and Linkage Disequilibrium; 2.6 Natural Selection; 2.6.1 Single-Locus Diallelic Selection Models; 2.6.2 Multilocus Selection Models; 2.7 Genealogy of Forward-Time Simulations; 2.7.1 Genealogy of Haploid Simulations; 2.7.2 Genealogy of Diploid Simulations; References; 3 ASCERTAINMENT BIAS IN POPULATION GENETICS; 3.1 Introduction; 3.2 Methods; 3.2.1 Evolution of a DNA Repeat Locus
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3.2.2 Conditional Distributions and Ascertainment Bias of Allele Sizes3.2.3 Simulation Method; 3.3 Results; 3.3.1 Summary of Modeling Results; 3.3.2 Comparisons of Empirical Statistics Derived from Human and Chimpanzee Microsatellite Data; 3.4 Discussion and Conclusions; References; 4 OBSERVING PROPERTIES OF EVOLVING POPULATIONS; 4.1 Introduction; 4.1.1 Allelic Spectra of Complex Human Diseases; 4.1.2 An Evolutionary Model of Effective Number of Disease Alleles; 4.1.3 Simulation of the Evolution of ne; 4.2 Simulation of the Evolution of Allele Spectra; 4.2.1 Demographic Models
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4.2.2 Output Statistics4.2.3 Mutation Models; 4.2.4 Multilocus Selection Models; 4.2.5 Evolve!; 4.2.6 Validation of Theoretical Results; 4.3 Extensions to the Basic Model; 4.3.1 Impact of Demographic Models; 4.3.2 Impact of the Mutation Model; 4.3.3 Impact of Subpopulation Structure; 4.3.4 Impact of Migration; 4.3.5 Distribution of Equilibrium Disease Allele Frequency; 4.3.6 Varying Selection and Mutation Coefficients; 4.3.7 Evolution of Disease Predisposing Loci Under Weak Selection; 4.3.8 Discussion; References; 5 SIMULATING POPULATIONS WITH COMPLEX HUMAN DISEASES; 5.1 Introduction
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5.2 Controlling Disease Allele Frequencies at the Present Generation
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Electronic reproduction; Available via World Wide Web
Additional Edition:
9781118180327
Additional Edition:
1118180321
Additional Edition:
1118180356
Additional Edition:
9781118180327
Additional Edition:
9781118180358
Additional Edition:
Erscheint auch als Druck-Ausgabe Forward-Time Population Genetics Simulations : Methods, Implementation, and Applications
Language:
English
Keywords:
Electronic books
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