Format:
Online-Ressource (xi, 41 pages)
,
illustrations (some color)
Edition:
Online-Ausg.
ISBN:
9783319224558
Series Statement:
SpringerBriefs in microbiology
Content:
This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed
Note:
Includes bibliographical references
,
Preface; Contents; Abstract; 1 Streptococcal Superantigens; Abstract; 1 Streptococcus pyogenes; 1.1 Introduction; 1.2 Epidemiology of Streptococcal Infections; 1.3 Clinical Manifestations; 1.3.1 Pharyngitis and Scarlet Fever; 1.3.2 Pyoderma and Skin Infections; 1.3.3 Invasive Diseases: Toxic Shock Syndrome and Necrotizing Fasciitis; 1.3.4 Post-Infection Immune Sequelae: Rheumatic Fever and Glomerulonephritis (PSGN); 1.4 Virulence Factors of Streptococcus pyogenes; 2 Superantigens (SAg); 2.1 Introduction; 2.2 Detection of Superantigens; 2.2.1 Pre-genomics Era; 2.2.2 Post-genomics Era
,
2.2.3 Diversity in Streptococcal Superantigen Genes2.3 Mechanism of Action; 2.3.1 T-Cell Fate After/on Encountering Superantigen; 2.3.2 Role of CD28 in Functioning of Superantigen; 2.3.3 Potency of Superantigen; 2.3.4 Biochemical Properties of Streptococcal Superantigens: Zinc Binding; 2.4 Structure and Function; 2.4.1 Conserved Scaffold of Superantigen; 2.4.2 MHC-II alpha - Chain Binding; 2.4.3 MHC-II beta - Chain Binding; 2.4.4 SAg Oligomerization; 2.4.5 Cross-Linking of MHC-II; 2.5 Association of SAg with Disease; 2.5.1 Invasive Diseases and Toxic Shock Syndrome (TSS)
,
2.5.2 SAg and AutoimmunityRheumatic Fever; Kawasaki Disease; Psoriasis; 2.5.3 Other Diseases; 2.6 Host Factors: Role of HLA Type; 2.7 Evolutionary Paths of Streptococcal and Staphylococcal SAgs; 3 Therapeutic Strategies to Combat SAg; 3.1 Intravenous Immunoglobulins (IVIG); 3.1.1 Mechanism of Action of IVIG; 3.1.2 Variation of Cytokine Responses; 3.1.3 Clinical Studies; 3.2 Pyrogenic Superantigens as Cures for Human Diseases; 3.3 Why Bacteria Produce SAg; 3.4 Concluding Remarks; References
Additional Edition:
3319224557
Additional Edition:
9783319224541
Additional Edition:
9783319224558
Additional Edition:
Erscheint auch als Druck-Ausgabe Streptococcal Superantigens
Language:
English
URL:
Volltext
(lizenzpflichtig)
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