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It Takes Two to Tango: Controlling Human Mesenchymal Stromal Cell Response via Substrate Stiffness and Surface Topography (2023)

Ribeiro, Sofia [Verfasser] ; Watigny, Alexandre [Verfasser] ; Bayon, Yves [Verfasser] ; [et al.]

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UID:

(DE-101)1312102977

Format: Online-Ressource

ISSN: 2699-9307

Content: Cells sense extracellular matrix‐induced biophysical signals, which are transduced into intracellular signaling cascades, and trigger a series of cell responses, including adhesion, migration, and lineage commitment. Traditionally, in in vitro context, monofactorial approaches are employed to control cell fate, despite the fact that in vivo cells are exposed simultaneously to a diverse range of signals. Herein, an overview of key mechanotransduction pathways is first provided. Conventional single‐factor and contemporary multifactorial methodologies, based on substrate rigidity and surface topography, are then reviewed to recapitulate in vitro the in vivo niche, in an attempt to elucidate the underlying mechanisms involved in human mesenchymal stromal cell‐material interactions.

In: day:03

In: month:12

In: year:2023

In: extent:15

In: Advanced nanoBiomed research, Weinheim : Wiley-VCH, [2021]-, (03.12.2023) (gesamt 15), 2699-9307

Language: English

DOI: 10.1002/anbr.202300042

URN: urn:nbn:de:101:1-2023120414205865052235

URL: https://doi.org/10.1002/anbr.202300042

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023120414205865052235

URL: https://d-nb.info/1312102977/34

URL: https://doi.org/10.1002/anbr.202300042

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Ultrasound‐Powered Implants: A Critical Review of Piezoelectric Material Selection and Applications (2021)

Turner, Brendan L. [Verfasser] ; Senevirathne, Seedevi [Verfasser] ; Kilgour, Katie [Verfasser] ; [et al.]

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UID:

(DE-101)1236728084

Format: Online-Ressource

ISSN: 2192-2659

In: day:08

In: month:07

In: year:2021

In: extent:25

In: Advanced healthcare materials, Weinheim : Wiley-VCH, 2012-, (08.07.2021) (gesamt 25), 2192-2659

Language: English

DOI: 10.1002/adhm.202100986

URN: urn:nbn:de:101:1-2021070815151211235942

URL: https://doi.org/10.1002/adhm.202100986

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2021070815151211235942

URL: https://d-nb.info/1236728084/34

URL: https://doi.org/10.1002/adhm.202100986

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Micromotion Derived Fluid Shear Stress Mediates Peri‐Electrode Gliosis through Mechanosensitive Ion Channels (2023)

Trotier, Alexandre [Verfasser] ; Bagnoli, Enrico [Verfasser] ; Walski, Tomasz [Verfasser] ; [et al.]

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UID:

(DE-101)1297768000

Format: Online-Ressource

ISSN: 2198-3844

Content: Abstract: The development of bioelectronic neural implant technologies has advanced significantly over the past 5 years, particularly in brain–machine interfaces and electronic medicine. However, neuroelectrode‐based therapies require invasive neurosurgery and can subject neural tissues to micromotion‐induced mechanical shear, leading to chronic inflammation, the formation of a peri‐electrode void and the deposition of reactive glial scar tissue. These structures act as physical barriers, hindering electrical signal propagation and reducing neural implant functionality. Although well documented, the mechanisms behind the initiation and progression of these processes are poorly understood. Herein, in silico analysis of micromotion‐induced peri‐electrode void progression and gliosis is described. Subsequently, ventral mesencephalic cells exposed to milliscale fluid shear stress in vitro exhibited increased expression of gliosis‐associated proteins and overexpression of mechanosensitive ion channels PIEZO1 (piezo‐type mechanosensitive ion channel component 1) and TRPA1 (transient receptor potential ankyrin 1), effects further confirmed in vivo in a rat model of peri‐electrode gliosis. Furthermore, in vitro analysis indicates that chemical inhibition/activation of PIEZO1 affects fluid shear stress mediated astrocyte reactivity in a mitochondrial‐dependent manner. Together, the results suggest that mechanosensitive ion channels play a major role in the development of a peri‐electrode void and micromotion‐induced glial scarring at the peri‐electrode region.

In: day:30

In: month:07

In: year:2023

In: extent:23

In: Advanced science, Weinheim : Wiley-VCH, 2014-, (30.07.2023) (gesamt 23), 2198-3844

Language: English

DOI: 10.1002/advs.202301352

URN: urn:nbn:de:101:1-2023073115091096962187

URL: https://doi.org/10.1002/advs.202301352

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023073115091096962187

URL: https://d-nb.info/1297768000/34

URL: https://doi.org/10.1002/advs.202301352

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Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials (2021)

Krukiewicz, Katarzyna [Verfasser] ; Britton, James [Verfasser] ; Więcławska, Daria [Verfasser] ; [et al.]

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UID:

(DE-101)122675239X

Format: Online-Ressource , online resource.

ISSN: 2045-2322 , 2045-2322

In: volume:11

In: number:1

In: day:14

In: month:1

In: year:2021

In: pages:1-10

In: date:12.2021

In: Scientific reports, [London] : Macmillan Publishers Limited, part of Springer Nature, 2011-, 11, Heft 1 (14.1.2021), 1-10, 12.2021, 2045-2322

Language: English

DOI: 10.1038/s41598-020-80361-7

URN: urn:nbn:de:101:1-2021020822575519957058

URL: https://doi.org/10.1038/s41598-020-80361-7

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2021020822575519957058

URL: https://d-nb.info/122675239X/34

URL: https://doi.org/10.1038/s41598-020-80361-7

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Analysis of a poly(ε-decalactone)/silver nanowire composite as an electrically conducting neural interface biomaterial (2019)

Krukiewicz, Katarzyna [Verfasser] ; Fernandez, Jorge [Verfasser] ; Skorupa, Małgorzata [Verfasser] ; [et al.]

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UID:

(DE-101)1184724857

Format: Online-Ressource , online resource.

ISSN: 2524-4426 , 2524-4426

In: volume:1

In: number:1

In: day:15

In: month:4

In: year:2019

In: pages:1-12

In: date:12.2019

In: BMC biomedical engineering, [London] : BioMed Central, [2019]-, 1, Heft 1 (15.4.2019), 1-12, 12.2019, 2524-4426

Language: English

DOI: 10.1186/s42490-019-0010-3

URN: urn:nbn:de:101:1-2019042800215542389887

URL: https://doi.org/10.1186/s42490-019-0010-3

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2019042800215542389887

URL: https://d-nb.info/1184724857/34

URL: https://doi.org/10.1186/s42490-019-0010-3

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A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells. (2024)

Fernandez‐Yague, Marc A. [Verfasser] ; Palma, Matteo [Verfasser] ; Tofail, Syed A. M. [Verfasser] ; [et al.]

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UID:

(DE-101)1345865678

Format: Online-Ressource

ISSN: 2198-3844

Content: Abstract: Preserving the function of human tendon‐derived cells (hTDCs) during cell expansion is a significant challenge in regenerative medicine. In this study, a non‐genetic approach is introduced to control the differentiation of hTDCs using a newly developed tympanic bioreactor. The system mimics the functionality of the human tympanic membrane, employing a piezoelectrically tuned acoustic diaphragm made of polyvinylidene fluoride‐co‐trifluoroethylene and boron nitride nanotubes. The diaphragm is vibrationally actuated to deliver targeted electromechanical stimulation to hTDCs. The results demonstrate that the system effectively maintains the tendon‐specific phenotype of hTDCs, even under conditions that typically induce nonspecific differentiation, such as osteogenesis. This stabilization is achieved by modulating integrin‐mediated mechanosignaling via ion channel‐regulated calcium activity, potentially by TREK‐1 and PIEZO1, yet targeted studies are required for confirmation. Finally, the system sustains the activation of key differentiation pathways (bone morphogenetic protein, BMP) while downregulating osteogenesis‐associated (mitogen‐ctivated protein kinase, MAPK and wingless integrated, WNT) pathways and upregulating Focal Adhesion Kinase (FAK) signaling. This approach offers a finely tunable, dose‐dependent control over hTDC differentiation, presenting significant potential for non‐genetic approaches in cell therapy, tendon tissue engineering, and the regeneration of other mechanosensitive tissues.

In: day:22

In: month:10

In: year:2024

In: extent:18

In: Advanced science, Weinheim : Wiley-VCH, 2014-, (22.10.2024) (gesamt 18), 2198-3844

Language: English

DOI: 10.1002/advs.202405711

URN: urn:nbn:de:101:1-2410231446555.807365970345

URL: https://doi.org/10.1002/advs.202405711

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2410231446555.807365970345

URL: https://d-nb.info/1345865678/34

URL: https://doi.org/10.1002/advs.202405711

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A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels (2021)

Fernandez‐Yague, Marc A. [Verfasser] ; Trotier, Alexandre [Verfasser] ; Demir, Secil [Verfasser] ; [et al.]

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UID:

(DE-101)1239606672

Format: Online-Ressource

ISSN: 1521-4095

In: day:23

In: month:08

In: year:2021

In: extent:18

In: Advanced materials, Weinheim : Wiley-VCH, 1989-, (23.08.2021) (gesamt 18), 1521-4095

Language: English

DOI: 10.1002/adma.202008788

URN: urn:nbn:de:101:1-2021082315050984081141

URL: https://doi.org/10.1002/adma.202008788

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2021082315050984081141

URL: https://d-nb.info/1239606672/34

URL: https://doi.org/10.1002/adma.202008788

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A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels (Adv. Mater. 40/2021) (2021)

Fernandez‐Yague, Marc A. [Verfasser] ; Trotier, Alexandre [Verfasser] ; Demir, Secil [Verfasser] ; [et al.]

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UID:

(DE-101)1242597514

Format: Online-Ressource

ISSN: 1521-4095

In: volume:33

In: number:40

In: year:2021

In: extent:1

In: Advanced materials, Weinheim : Wiley-VCH, 1989-, 33, Heft 40 (2021) (gesamt 1), 1521-4095

Language: English

DOI: 10.1002/adma.202170315

URN: urn:nbn:de:101:1-2021100615040338675481

URL: https://doi.org/10.1002/adma.202170315

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2021100615040338675481

URL: https://d-nb.info/1242597514/34

URL: https://doi.org/10.1002/adma.202170315

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