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  • 1
    UID:
    (DE-627)1677140658
    Format: 9
    ISSN: 2044-6055
    Content: Introduction The incidence of melanoma is increasing faster than any other major cancer both in Brazil and worldwide. The Southeast of Brazil has especially high incidences of melanoma, and early detection is low. Exposure to UV radiation represents a primary risk factor for developing melanoma. Increasing attractiveness is a major motivation for adolescents for tanning. A medical student-delivered intervention that harnesses the broad availability of mobile phones as well as adolescents’ interest in their appearance may represent a novel method to improve skin cancer prevention. - Methods and analysis We developed a free mobile app (Sunface), which will be implemented in at least 30 secondary school classes, each with 21 students (at least 30 classes with 21 students for control) in February 2018 in Southeast Brazil via a novel method called mirroring. In a 45 min classroom seminar, the students’ altered three-dimensional selfies on tablets are ‘mirrored’ via a projector in front of their entire class, showing the effects of unprotected UV exposure on their future faces. External block randomisation via computer is performed on the class level with a 1:1 allocation. Sociodemographic data, as well as skin type, ancestry, UV protection behaviour and its predictors are measured via a paper–pencil questionnaire before as well as at 3 and 6 months postintervention. The primary end point is the group difference in the 30-day prevalence of daily sunscreen use at a 6-month follow-up. Secondary end points include (1) the difference in daily sunscreen use at a 3-month follow-up, (2) if a self-skin examination in accordance with the ABCDE rule was performed within the 6-month follow-up and (3) the number of tanning sessions. - Ethics and dissemination Ethical approval was obtained from the ethics committee of the University of Itauna. Results will be disseminated at conferences and in peer-reviewed journals. - Trial registration number NCT03178240; Pre-results.
    Note: Gesehen am 17.09.2019
    In: BMJ open, London : BMJ Publishing Group, 2011, 8(2018,3) Artikel-Nummer e018299, 9 Seiten, 2044-6055
    In: volume:8
    In: year:2018
    In: number:3
    In: extent:9
    Language: English
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  • 2
    UID:
    (DE-627)1577835409
    Format: 10
    ISSN: 1438-8871
    Content: Background: Around 90% of melanomas are caused by exposure to ultraviolet (UV) radiation and are therefore eminently preventable. Tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to malignant melanoma and other skin cancers are too far in the future to fathom. Given the substantial amount of time children and adolescents spend in schools, as well as with their mobile phones, addressing melanoma prevention via both of these ways is crucial. However, no school-based intervention using mobile apps has been evaluated to date. We recently released a photoaging mobile app, in which a selfie is altered to predict future appearance dependent on UV protection behavior and skin type. Objective: In this pilot study, we aimed to use mobile phone technology to improve school-based melanoma prevention and measure its preliminary success in different subgroups of students with regard to their UV protection behavior, Fitzpatrick skin type and age. Methods: We implemented a free photoaging mobile phone app (Sunface) in 2 German secondary schools via a method called mirroring. We “mirrored” the students’ altered 3-dimensional (3D) selfies reacting to touch on mobile phones or tablets via a projector in front of their whole grade. Using an anonymous questionnaire capturing sociodemographic data as well as risk factors for melanoma we then measured their perceptions of the intervention on a 5-point Likert scale among 205 students of both sexes aged 13-19 years (median 15 years). Results: We measured more than 60% agreement in both items that measured motivation to reduce UV exposure and only 12.5% disagreement: 126 (63.0%) agreed or strongly agreed that their 3D selfie motivated them to avoid using a tanning bed, and 124 (61.7%) to increase use of sun protection. However, only 25 (12.5%) disagreed with both items. The perceived effect on motivation was increased in participants with Fitzpatrick skin types 1-2 in both tanning bed avoidance (n=74, 71.8% agreement in skin types 1-2 vs n=50, 53.8% agreement in skin types 3-6) and increased use of sun protection (n=70, 68.0% agreement in skin types 1-2 vs n=52, 55.3% agreement in skin types 3-6), and also positively correlated with higher age. Conclusions: We present a novel way of integrating photoaging in school-based melanoma prevention that affects the students’ peer group, considers the predictors of UV exposure in accordance with the theory of planned behavior, and is particularly effective in changing behavioral predictors in fair-skinned adolescents (Fitzpatrick skin types 1-2). Further research is required to evaluate the intervention’s prospective effects on adolescents of various cultural backgrounds. [J Med Internet Res 2017;19(9):e319]
    Note: Gesehen am 23.07.2018
    In: Journal of medical internet research, Richmond, Va. : Healthcare World, 1999, 19(2017,9) Artikel-Nummer e319, 10 Seiten, 1438-8871
    In: volume:19
    In: year:2017
    In: number:9
    In: extent:10
    Language: English
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
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  • 3
    UID:
    (DE-605)HT020106520
    Format: 40 Seiten , Diagramme , 30 cm
    Note: Literaturverzeichnis: Seite 35-36 , Dissertation Johann Wolfgang Goethe-Universität Frankfurt am Main 2018 , Enthält Sonderabdrucke aus Zeitschrift in englischer Sprache , Zusammenfassung auf Deutsch und auf Englisch
    Language: English , German
    Keywords: Hochschulschrift
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  • 4
    UID:
    (DE-101)1156308909
    Format: 40 Seiten , Diagramme , 30 cm
    Note: Literaturverzeichnis: Seite 35-36 , Enthält Sonderabdrucke , Dissertation Johann Wolfgang Goethe-Universität Frankfurt am Main 2018 , Zusammenfassung auf Deutsch und auf Englisch
    Language: German
    Keywords: Hochschulschrift
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  • 5
    UID:
    (DE-627)1676792643
    Format: 2
    ISSN: 2168-6084
    Content: This survey study explores whether a single exposure of adult patients in a waiting room to an app that approximates facial UV damage may lead to altered UV protection behavior.
    Note: Gesehen am 12.09.2019
    In: JAMA dermatology, Chicago, Ill. : American Medical Association, 2013, 154(2018), 9, Seite 1085-1086, 2168-6084
    In: volume:154
    In: year:2018
    In: number:9
    In: pages:1085-1086
    In: extent:2
    Language: English
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  • 6
    UID:
    (DE-627)1577865146
    Format: 11
    ISSN: 1438-8871
    Content: Background: More than 8.5 million Germans suffer from chronic diseases attributable to smoking. Education Against Tobacco (EAT) is a multinational network of medical students who volunteer for school-based prevention in the classroom setting, amongst other activities. EAT has been implemented in 28 medical schools in Germany and is present in 13 additional countries around the globe. A recent quasi-experimental study showed significant short-term smoking cessation effects on 11-to-15-year-old adolescents. Objective: The aim of this study was to provide the first randomized long-term evaluation of the optimized 2014 EAT curriculum involving a photoaging software for its effectiveness in reducing the smoking prevalence among 11-to-15-year-old pupils in German secondary schools. Methods: A randomized controlled trial was undertaken with 1504 adolescents from 9 German secondary schools, aged 11-15 years in grades 6-8, of which 718 (47.74%) were identifiable for the prospective sample at the 12-month follow-up. The experimental study design included measurements at baseline (t1), 6 months (t2), and 12 months postintervention (t3), via questionnaire. The study groups consisted of 40 randomized classes that received the standardized EAT intervention (two medical student-led interactive modules taking 120 minutes total) and 34 control classes within the same schools (no intervention). The primary endpoint was the difference in smoking prevalence from t1 to t3 in the control group versus the difference from t1 to t3 in the intervention group. The differences in smoking behavior (smoking onset, quitting) between the two groups, as well as gender-specific effects, were studied as secondary outcomes. Results: None of the effects were significant due to a high loss-to-follow-up effect (52.26%, 786/1504). From baseline to the two follow-up time points, the prevalence of smoking increased from 3.1% to 5.2% to 7.2% in the control group and from 3.0% to 5.4% to 5.8% in the intervention group (number needed to treat [NNT]=68). Notable differences were observed between the groups for the female gender (4.2% to 9.5% for control vs 4.0% to 5.2% for intervention; NNT=24 for females vs NNT=207 for males), low educational background (7.3% to 12% for control vs 6.1% to 8.7% for intervention; NNT=30), and migrational background (students who claimed that at least one parent was not born in Germany) at the 12-month follow-up. The intervention appears to prevent smoking onset (NNT=63) but does not appear to initiate quitting. Conclusions: The intervention appears to prevent smoking, especially in females and students with a low educational background. [J Med Internet Res 2017;19(6):e199]
    Note: Gesehen am 24.07.2018
    In: Journal of medical internet research, Richmond, Va. : Healthcare World, 1999, 19(2017,6) Artikel-Nummer e199, 11 Seiten, 1438-8871
    In: volume:19
    In: year:2017
    In: number:6
    In: extent:11
    Language: English
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
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  • 7
    UID:
    (DE-627)1665290137
    Format: 3
    ISSN: 1952-4013
    Note: Gesehen am 13.05.2019
    In: European journal of dermatology, Montrouge : Libbey Eurotext, 1997, 28(2018), 4, Seite 532-534, 1952-4013
    In: volume:28
    In: year:2018
    In: number:4
    In: pages:532-534
    In: extent:3
    Language: English
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  • 8
    UID:
    (DE-627)1880872889
    Format: 80 Seiten , Illustrationen, Diagramme
    Note: Originalpublikationen sind in der Habilitationsschrift nicht enthalten , Habilitationsschrift Ruprecht-Karls-Universität Heidelberg 2024 , Titel Deutsch, Text in englischer Sprache
    Language: English
    Keywords: Hochschulschrift
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  • 9
    UID:
    (DE-627)1693339269
    Format: 12
    ISSN: 1422-0067
    Content: Development and homeostasis of the epidermis are governed by a complex network of sequence-specific transcription factors and epigenetic modifiers cooperatively regulating the subtle balance of progenitor cell self-renewal and terminal differentiation. To investigate the role of histone H2A deubiquitinase 2A-DUB/Mysm1 in the skin, we systematically analyzed expression, developmental functions, and potential interactions of this epigenetic regulator using Mysm1-deficient mice and skin-derived epidermal cells. Morphologically, skin of newborn and young adult Mysm1-deficient mice was atrophic with reduced thickness and cellularity of epidermis, dermis, and subcutis, in context with altered barrier function. Skin atrophy correlated with reduced proliferation rates in Mysm1−/− epidermis and hair follicles, and increased apoptosis compared with wild-type controls, along with increases in DNA-damage marker γH2AX. In accordance with diminished α6-Integrinhigh+CD34+ epidermal stem cells, reduced colony formation of Mysm1−/− epidermal progenitors was detectable in vitro. On the molecular level, we identified p53 as potential mediator of the defective Mysm1-deficient epidermal compartment, resulting in increased pro-apoptotic and anti-proliferative gene expression. In Mysm1−/−p53−/− double-deficient mice, significant recovery of skin atrophy was observed. Functional properties of Mysm1−/− developing epidermis were assessed by quantifying the transepidermal water loss. In summary, this investigation uncovers a role for 2A-DUB/Mysm1 in suppression of p53-mediated inhibitory programs during epidermal development.
    Note: Gesehen am 26.03.2020
    In: International journal of molecular sciences, Basel : Molecular Diversity Preservation International, 2000, 19(2018,3) Artikel-Nummer 687, 12 Seiten, 1422-0067
    In: volume:19
    In: year:2018
    In: number:3
    In: extent:12
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Volltext  (lizenzpflichtig)
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  • 10
    UID:
    (DE-627)1681152398
    Format: 11
    ISSN: 1879-0852
    Content: Study aim - Melanomas arising in acral sites are associated with a poorer prognosis than other melanoma subtypes. The aim of this study was to evaluate clinical-pathological and genetic characteristics as well as therapeutic responses of a larger cohort of patients with melanomas arising in acral sites. - Methods - Clinical data of 134 patients with melanomas arising in acral sites from the Dept. of Dermatology Essen were collected and analysed with regard to clinicopathological characteristics and treatment responses. Genetic analysis with targeted next-generation sequencing was done on 50 samples. - Results - In our cohort, BRAF (30%), NRAS (28%), TERT promoter (26%), NF1 (14%) and KIT (6%) were frequently identified mutations. Comparing tumours situated on palms and soles with melanomas arising on dorsal acral sites, a higher frequency of NRAS (39.1% versus 25%) and NF1 (17.3% versus 0%) and lower frequencies of BRAF (21.7% versus 75%) and TERT promoter (8.6% versus 50%) mutations were observed. MAPK activating mutations were identified in 64% of tumours. Overall survival was longer in patients treated with immune checkpoint inhibitors as first-line treatment than in patients receiving other systemic therapies (i.e. BRAF/MEK inhibitors and chemotherapy). - Conclusion - Our data suggest that the genetics of melanomas arising in acral sites varies by tumour location and may influence biological behaviour.
    Note: Gesehen am 06.11.2019
    In: European journal of cancer, Amsterdam [u.a.] : Elsevier, 1992, 119(2019), Seite 66-76, 1879-0852
    In: volume:119
    In: year:2019
    In: pages:66-76
    In: extent:11
    Language: English
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