Format:
Online-Ressource
ISSN:
1521-4141
Content:
In the bone marrow (BM), memory plasma cells (PCs) survive for long time periods in dedicated microenvironmental survival niches, resting in terms of proliferation. Several cell types, such as eosinophils and reticular stromal cells, have been reported to contribute to the survival niche of memory PCs. However, until now it has not been demonstrated whether the niche is formed by a fixed cellular microenvironment. By intravital microscopy, we provide for the first time evidence that the direct contacts formed between PCs and reticular stromal cells are stable in vivo, and thus the PCs are sessile in their niches. The majority (∼80%) of PCs directly contact reticular stromal cells in a non‐random fashion. The mesenchymal reticular stromal cells in contact with memory PCs are not proliferating. On the other hand, we show here that eosinophils in the vicinity of long‐lived PCs are vigorously proliferating cells and represent a dynamic component of the survival niche. In contrast, if eosinophils are depleted by irradiation, newly generated eosinophils localize in the vicinity of radiation‐resistant PCs and the stromal cells. These results suggest that memory PC niches may provide attraction for eosinophils to maintain stability with fluctuating yet essential accessory cells.
In:
volume:44
In:
number:8
In:
year:2014
In:
pages:2306-2317
In:
extent:12
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 44, Heft 8 (2014), 2306-2317 (gesamt 12), 1521-4141
Language:
English
DOI:
10.1002/eji.201344313
URN:
urn:nbn:de:101:1-2023011905313189621225
URL:
https://doi.org/10.1002/eji.201344313
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023011905313189621225
URL:
https://d-nb.info/1278561994/34
URL:
https://doi.org/10.1002/eji.201344313
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