Format:
7
ISSN:
1546-1718
Content:
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death1,2. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups3,4,5,6,7. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery8.
Note:
Gesehen am 19.07.2018
In:
Nature genetics, London : Macmillan Publishers Limited, part of Springer Nature, 1992, 49(2017), 6, Seite 946-952, 1546-1718
In:
volume:49
In:
year:2017
In:
number:6
In:
pages:946-952
In:
extent:7
Language:
English
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